Gene name: CWH43
Reference locus (S288C): YCR017C
Gene biotype: protein_coding
Description: Protein CWH43; GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion; In the C-terminal section; belongs to the PGAP2IP family
Top 10 interactors (score): PER1 (0.937); TED1 (0.905); GPI13 (0.835); GPI12 (0.814); GPI18 (0.814); MCD4 (0.805); CWH41 (0.779); YCR099C (0.766); GPI14 (0.76); PMT1 (0.757); PMT2 (0.732); GPI16 (0.722); GWT1 (0.721); LAS21 (0.698); YCP4 (0.697); BCK2 (0.684); ROT2 (0.676); GCD10 (0.673); YMD8 (0.658); GAB1 (0.658)
Homologues (species, bitscore): CWH43 (Homo sapiens, 267.3); Cwh43 (Mus musculus, 270.8); pgap2 (Danio rerio, 50.4); CG3876 (Drosophila melanogaster, 51.2); tag-189 (Caenorhabditis elegans, 63.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:139247-142108:- | gene-YCR017C_AKU4011 | rna-NM_001178730.1_AKU4011 | cds-NP_009943.2_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000178.1:3998-6859:+ | gene-YCR017C_BG1 | rna-NM_001178730.1_BG1 | cds-NP_009943.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:135560-138421:- | gene-YCR017C_Bruggeman | rna-NM_001178730.1_Bruggeman | cds-NP_009943.2_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:145609-148470:- | gene-YCR017C_CAT1 | rna-NM_001178730.1_CAT1 | cds-NP_009943.2_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | MBVS01000051.1:2441-5302:+ | gene-YCR017C_CBS1585 | rna-NM_001178730.1_CBS1585 | cds-NP_009943.2_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:145158-148019:- | gene-YCR017C_CBS436 | rna-NM_001178730.1_CBS436 | cds-NP_009943.2_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:127362-130223:- | gene-YCR017C_CBS6412 | rna-NM_001178730.1_CBS6412 | cds-NP_009943.2_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:139692-142553:- | gene-YCR017C_CBS6413 | rna-NM_001178730.1_CBS6413 | cds-NP_009943.2_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:125633-128494:- | gene-YCR017C_CENPK1137D | rna-NM_001178730.1_CENPK1137D | cds-NP_009943.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:137266-140127:- | gene-YCR017C_EthanolRed | rna-NM_001178730.1_EthanolRed | cds-NP_009943.2_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:140063-142924:- | gene-YCR017C_FaliES1 | rna-NM_001178730.1_FaliES1 | cds-NP_009943.2_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000232.1:3918-6779:+ | gene-YCR017C_JAY291 | rna-NM_001178730.1_JAY291 | cds-NP_009943.2_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:132867-135728:- | gene-YCR017C_MUCL30387 | rna-NM_001178730.1_MUCL30387 | cds-NP_009943.2_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:131736-134597:- | gene-YCR017C_MUCL30388 | rna-NM_001178730.1_MUCL30388 | cds-NP_009943.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:140316-143177:- | gene-YCR017C_MUCL39482 | rna-NM_001178730.1_MUCL39482 | cds-NP_009943.2_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:136383-139244:- | gene-YCR017C_MUCL42920 | rna-NM_001178730.1_MUCL42920 | cds-NP_009943.2_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:144405-147266:- | gene-YCR017C_NCIM3186 | rna-NM_001178730.1_NCIM3186 | cds-NP_009943.2_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:141046-143907:- | gene-YCR017C_NCYC1407 | rna-NM_001178730.1_NCYC1407 | cds-NP_009943.2_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:144892-147753:- | gene-YCR017C_PE2H3 | rna-NM_001178730.1_PE2H3 | cds-NP_009943.2_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:145430-148291:- | gene-YCR017C_PE2H4 | rna-NM_001178730.1_PE2H4 | cds-NP_009943.2_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:144773-147634:- | gene-YCR017C_S288C | rna-NM_001178730.1_S288C | cds-NP_009943.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000073.1:4035-6896:+ | gene-YCR017C_SA1 | rna-NM_001178730.1_SA1 | cds-NP_009943.2_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:140132-142993:- | gene-YCR017C_ThermosaccDry | rna-NM_001178730.1_ThermosaccDry | cds-NP_009943.2_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:150961-153822:- | gene-YCR017C_VR1 | rna-NM_001178730.1_VR1 | cds-NP_009943.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:139067-141928:- | gene-YCR017C_ZTW1 | rna-NM_001178730.1_ZTW1 | cds-NP_009943.2_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:172466-175330:- | gene-YCR017C_Sparadoxus | rna-NM_001178730.1_Sparadoxus | cds-NP_009943.2_Sparadoxus | 90.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |