Gene name: CUP9
Reference locus (S288C): YPL177C
Gene biotype: protein_coding
Description: Homeobox protein CUP9; Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): UBR1 (0.991); PTR2 (0.914); SOK1 (0.817); YAP6 (0.803); NRG1 (0.778); ATE1 (0.762); ROX1 (0.72); CIN5 (0.718); UBR2 (0.705); AAP1 (0.695); RIM101 (0.69); YDR102C (0.677); MFG1 (0.671); CYC8 (0.632); UFD4 (0.603); SOK2 (0.6); SKN7 (0.584); CYR1 (0.58); UME6 (0.577); PHD1 (0.573)
Homologues (species, bitscore): PKNOX2 (Homo sapiens, 73.9); Pknox2 (Mus musculus, 73.9); pknox2 (Danio rerio, 74.7); pknox2 (Xenopus tropicalis, 77.4); hth (Drosophila melanogaster, 73.2); unc-62 (Caenorhabditis elegans, 67.4); BLH4 (Arabidopsis thaliana, 62.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:190711-191631:- | gene-YPL177C_AKU4011 | rna-NM_001183991.1_AKU4011 | cds-NP_015148.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:396378-397298:- | gene-YPL177C_BG1 | rna-NM_001183991.1_BG1 | cds-NP_015148.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:216555-217475:- | gene-YPL177C_Bruggeman | rna-NM_001183991.1_Bruggeman | cds-NP_015148.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:213365-214285:- | gene-YPL177C_CAT1 | rna-NM_001183991.1_CAT1 | cds-NP_015148.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:194773-195693:- | gene-YPL177C_CBS1585 | rna-NM_001183991.1_CBS1585 | cds-NP_015148.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:209432-210352:- | gene-YPL177C_CBS436 | rna-NM_001183991.1_CBS436 | cds-NP_015148.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:199449-200369:- | gene-YPL177C_CBS6412 | rna-NM_001183991.1_CBS6412 | cds-NP_015148.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:191412-192332:- | gene-YPL177C_CBS6413 | rna-NM_001183991.1_CBS6413 | cds-NP_015148.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:212922-213842:- | gene-YPL177C_CENPK1137D | rna-NM_001183991.1_CENPK1137D | cds-NP_015148.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:189451-190371:- | gene-YPL177C_EthanolRed | rna-NM_001183991.1_EthanolRed | cds-NP_015148.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:197043-197963:- | gene-YPL177C_FaliES1 | rna-NM_001183991.1_FaliES1 | cds-NP_015148.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:167942-168862:+ | gene-YPL177C_JAY291 | rna-NM_001183991.1_JAY291 | cds-NP_015148.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:207938-208858:- | gene-YPL177C_MUCL30387 | rna-NM_001183991.1_MUCL30387 | cds-NP_015148.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:205958-206878:- | gene-YPL177C_MUCL30388 | rna-NM_001183991.1_MUCL30388 | cds-NP_015148.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:188102-189022:- | gene-YPL177C_MUCL39482 | rna-NM_001183991.1_MUCL39482 | cds-NP_015148.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:244790-245710:- | gene-YPL177C_MUCL42920 | rna-NM_001183991.1_MUCL42920 | cds-NP_015148.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:213025-213945:- | gene-YPL177C_NCIM3186 | rna-NM_001183991.1_NCIM3186 | cds-NP_015148.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:194558-195478:- | gene-YPL177C_NCYC1407 | rna-NM_001183991.1_NCYC1407 | cds-NP_015148.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:201994-202914:- | gene-YPL177C_PE2H3 | rna-NM_001183991.1_PE2H3 | cds-NP_015148.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:201637-202557:- | gene-YPL177C_PE2H4 | rna-NM_001183991.1_PE2H4 | cds-NP_015148.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:213042-213962:- | gene-YPL177C_S288C | rna-NM_001183991.1_S288C | cds-NP_015148.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:159716-160636:+ | gene-YPL177C_SA1 | rna-NM_001183991.1_SA1 | cds-NP_015148.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:196841-197761:- | gene-YPL177C_ThermosaccDry | rna-NM_001183991.1_ThermosaccDry | cds-NP_015148.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:211767-212687:- | gene-YPL177C_VR1 | rna-NM_001183991.1_VR1 | cds-NP_015148.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:196171-197091:- | gene-YPL177C_ZTW1 | rna-NM_001183991.1_ZTW1 | cds-NP_015148.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:197750-198640:- | gene-YPL177C_Sparadoxus | rna-NM_001183991.1_Sparadoxus | cds-NP_015148.1_Sparadoxus | 86.8 | 96.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |