Gene name: CTK1
Reference locus (S288C): YKL139W
Gene biotype: protein_coding
Description: Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
Top 10 interactors (score): CTK2 (0.999); CTK3 (0.999); RPO21 (0.999); SPT5 (0.987); CCL1 (0.973); SGV1 (0.963); FCP1 (0.957); KIN28 (0.945); CDC28 (0.943); SPT4 (0.943); CKS1 (0.934); PHO85 (0.926); SER2 (0.921); CLN2 (0.921); SSU72 (0.919); PHO80 (0.918); SSL2 (0.913); RAD3 (0.913); CLB1 (0.91); TFB3 (0.908)
Homologues (species, bitscore): CDK12 (Homo sapiens, 291.2); Cdk12 (Mus musculus, 290.4); cdk12 (Danio rerio, 287.3); cdk12 (Xenopus tropicalis, 285.0); Cdk12 (Drosophila melanogaster, 283.5); cdtl-7 (Caenorhabditis elegans, 273.5); CDKC;1 (Arabidopsis thaliana, 298.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:169840-171441:+ | gene-YKL139W_AKU4011 | rna-NM_001179705.1_AKU4011 | cds-NP_012783.1_AKU4011 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:147000-148604:+ | gene-YKL139W_BG1 | rna-NM_001179705.1_BG1 | cds-NP_012783.1_BG1 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:187502-189103:+ | gene-YKL139W_Bruggeman | rna-NM_001179705.1_Bruggeman | cds-NP_012783.1_Bruggeman | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:182815-184403:+ | gene-YKL139W_CAT1 | rna-NM_001179705.1_CAT1 | cds-NP_012783.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:182092-183693:+ | gene-YKL139W_CBS1585 | rna-NM_001179705.1_CBS1585 | cds-NP_012783.1_CBS1585 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:180671-182259:+ | gene-YKL139W_CBS436 | rna-NM_001179705.1_CBS436 | cds-NP_012783.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:166714-168315:+ | gene-YKL139W_CBS6412 | rna-NM_001179705.1_CBS6412 | cds-NP_012783.1_CBS6412 | 98.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:182537-184138:+ | gene-YKL139W_CBS6413 | rna-NM_001179705.1_CBS6413 | cds-NP_012783.1_CBS6413 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:182602-184188:+ | gene-YKL139W_CENPK1137D | rna-NM_001179705.1_CENPK1137D | cds-NP_012783.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:180572-182173:+ | gene-YKL139W_EthanolRed | rna-NM_001179705.1_EthanolRed | cds-NP_012783.1_EthanolRed | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:181384-182985:+ | gene-YKL139W_FaliES1 | rna-NM_001179705.1_FaliES1 | cds-NP_012783.1_FaliES1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000357.1:3711-5315:+ | gene-YKL139W_JAY291 | rna-NM_001179705.1_JAY291 | cds-NP_012783.1_JAY291 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:189600-191204:+ | gene-YKL139W_MUCL30387 | rna-NM_001179705.1_MUCL30387 | cds-NP_012783.1_MUCL30387 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:183952-185556:+ | gene-YKL139W_MUCL30388 | rna-NM_001179705.1_MUCL30388 | cds-NP_012783.1_MUCL30388 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:181870-183471:+ | gene-YKL139W_MUCL39482 | rna-NM_001179705.1_MUCL39482 | cds-NP_012783.1_MUCL39482 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:186263-187859:+ | gene-YKL139W_MUCL42920 | rna-NM_001179705.1_MUCL42920 | cds-NP_012783.1_MUCL42920 | 98.4 | 99.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:182947-184533:+ | gene-YKL139W_NCIM3186 | rna-NM_001179705.1_NCIM3186 | cds-NP_012783.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:182060-183661:+ | gene-YKL139W_NCYC1407 | rna-NM_001179705.1_NCYC1407 | cds-NP_012783.1_NCYC1407 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:189179-190783:+ | gene-YKL139W_PE2H3 | rna-NM_001179705.1_PE2H3 | cds-NP_012783.1_PE2H3 | 98.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:185461-187049:+ | gene-YKL139W_PE2H4 | rna-NM_001179705.1_PE2H4 | cds-NP_012783.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:182958-184544:+ | gene-YKL139W_S288C | rna-NM_001179705.1_S288C | cds-NP_012783.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:99402-100990:+ | gene-YKL139W_SA1 | rna-NM_001179705.1_SA1 | cds-NP_012783.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:182084-183685:+ | gene-YKL139W_ThermosaccDry | rna-NM_001179705.1_ThermosaccDry | cds-NP_012783.1_ThermosaccDry | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:181437-183041:+ | gene-YKL139W_VR1 | rna-NM_001179705.1_VR1 | cds-NP_012783.1_VR1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:180619-182220:+ | gene-YKL139W_ZTW1 | rna-NM_001179705.1_ZTW1 | cds-NP_012783.1_ZTW1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:197327-198898:+ | gene-YKL139W_Sparadoxus | rna-NM_001179705.1_Sparadoxus | cds-NP_012783.1_Sparadoxus | 88.4 | 98.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |