Gene name: CSE4
Reference locus (S288C): YKL049C
Gene biotype: protein_coding
Description: Histone H3-like centromere protein; associated with promoters, accessible chromatin, RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore function; levels regulated by E3 ubiquitin ligase Psh1p; phosphorylation may destabilize defective kinetochores to promote bi-orientation; ubiquitination of N-terminus regulates proteolysis for faithful chromosome segregation; yeast CSE4 can complement mutations in human homolog CENPA
Top 10 interactors (score): HHF1 (0.999); CTF19 (0.999); MIF2 (0.999); SCM3 (0.999); OKP1 (0.997); HTA1 (0.997); HTA2 (0.996); AME1 (0.995); PSH1 (0.995); CHL4 (0.994); HTB1 (0.994); HTB2 (0.994); HHF2 (0.994); ASF1 (0.988); MCM21 (0.988); MTW1 (0.987); CBF1 (0.986); IPL1 (0.982); DSN1 (0.98); NUF2 (0.977)
Homologues (species, bitscore): HIST2H3D (Homo sapiens, 137.9); Hist1h3f (Mus musculus, 137.9); Si:dkey-108k21.25 (Danio rerio, 137.9); ENSXETP00000057894 (Xenopus tropicalis, 137.9); FBpp0085250 (Drosophila melanogaster, 137.9); his-74 (Caenorhabditis elegans, 136.3); AT4G40030 (Arabidopsis thaliana, 136.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:332074-332763:- | gene-YKL049C_AKU4011 | rna-NM_001179615.1_AKU4011 | cds-NP_012875.2_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:311244-311933:+ | gene-YKL049C_BG1 | rna-NM_001179615.1_BG1 | cds-NP_012875.2_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:351102-351791:- | gene-YKL049C_Bruggeman | rna-NM_001179615.1_Bruggeman | cds-NP_012875.2_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:347533-348222:- | gene-YKL049C_CAT1 | rna-NM_001179615.1_CAT1 | cds-NP_012875.2_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:344805-345494:- | gene-YKL049C_CBS1585 | rna-NM_001179615.1_CBS1585 | cds-NP_012875.2_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:342935-343624:- | gene-YKL049C_CBS436 | rna-NM_001179615.1_CBS436 | cds-NP_012875.2_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:328938-329627:- | gene-YKL049C_CBS6412 | rna-NM_001179615.1_CBS6412 | cds-NP_012875.2_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:344766-345455:- | gene-YKL049C_CBS6413 | rna-NM_001179615.1_CBS6413 | cds-NP_012875.2_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:345734-346423:- | gene-YKL049C_CENPK1137D | rna-NM_001179615.1_CENPK1137D | cds-NP_012875.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:342760-343449:- | gene-YKL049C_EthanolRed | rna-NM_001179615.1_EthanolRed | cds-NP_012875.2_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:343573-344262:- | gene-YKL049C_FaliES1 | rna-NM_001179615.1_FaliES1 | cds-NP_012875.2_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000080.1:48498-49187:- | gene-YKL049C_JAY291 | rna-NM_001179615.1_JAY291 | cds-NP_012875.2_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:352003-352692:- | gene-YKL049C_MUCL30387 | rna-NM_001179615.1_MUCL30387 | cds-NP_012875.2_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:346892-347581:- | gene-YKL049C_MUCL30388 | rna-NM_001179615.1_MUCL30388 | cds-NP_012875.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:344101-344790:- | gene-YKL049C_MUCL39482 | rna-NM_001179615.1_MUCL39482 | cds-NP_012875.2_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:348957-349646:- | gene-YKL049C_MUCL42920 | rna-NM_001179615.1_MUCL42920 | cds-NP_012875.2_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:346064-346753:- | gene-YKL049C_NCIM3186 | rna-NM_001179615.1_NCIM3186 | cds-NP_012875.2_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:344296-344985:- | gene-YKL049C_NCYC1407 | rna-NM_001179615.1_NCYC1407 | cds-NP_012875.2_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:368841-369530:- | gene-YKL049C_PE2H3 | rna-NM_001179615.1_PE2H3 | cds-NP_012875.2_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:353580-354269:- | gene-YKL049C_PE2H4 | rna-NM_001179615.1_PE2H4 | cds-NP_012875.2_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:346075-346764:- | gene-YKL049C_S288C | rna-NM_001179615.1_S288C | cds-NP_012875.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000027.1:24181-24870:- | gene-YKL049C_SA1 | rna-NM_001179615.1_SA1 | cds-NP_012875.2_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:344763-345452:- | gene-YKL049C_ThermosaccDry | rna-NM_001179615.1_ThermosaccDry | cds-NP_012875.2_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:343909-344598:- | gene-YKL049C_VR1 | rna-NM_001179615.1_VR1 | cds-NP_012875.2_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:342775-343464:- | gene-YKL049C_ZTW1 | rna-NM_001179615.1_ZTW1 | cds-NP_012875.2_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:362038-362727:- | gene-YKL049C_Sparadoxus | rna-NM_001179615.1_Sparadoxus | cds-NP_012875.2_Sparadoxus | 88.7 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |