Gene name: COT1
Reference locus (S288C): YOR316C
Gene biotype: protein_coding
Description: Solute carrier family 30 (zinc transporter), member 1; Cobalt uptake protein COT1; Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
Top 10 interactors (score): ZRC1 (0.999); ZRG17 (0.959); YKE4 (0.957); ZRT3 (0.953); ZRT2 (0.917); ZRT1 (0.902); ATX2 (0.833); SMF3 (0.813); CCC2 (0.811); SMF1 (0.792); CCC1 (0.787); FMP42 (0.774); ZAP1 (0.754); FET4 (0.748); FTH1 (0.744); SSH4 (0.721); CBK1 (0.719); TUL1 (0.685); YPQ1 (0.675); FET3 (0.656)
Homologues (species, bitscore): SLC30A1 (Homo sapiens, 231.5); Slc30a1 (Mus musculus, 234.6); slc30a1b (Danio rerio, 251.5); slc30a1 (Xenopus tropicalis, 224.6); ZnT63C (Drosophila melanogaster, 256.9); cdf-1 (Caenorhabditis elegans, 189.5); AT2G04620 (Arabidopsis thaliana, 157.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:896723-898041:- | gene-YOR316C_AKU4011 | rna-NM_001183736.3_AKU4011 | cds-NP_014961.3_AKU4011 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:298730-300049:- | gene-YOR316C_BG1 | rna-NM_001183736.3_BG1 | cds-NP_014961.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:882136-883455:- | gene-YOR316C_Bruggeman | rna-NM_001183736.3_Bruggeman | cds-NP_014961.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:882848-884167:- | gene-YOR316C_CAT1 | rna-NM_001183736.3_CAT1 | cds-NP_014961.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:880543-881861:- | gene-YOR316C_CBS1585 | rna-NM_001183736.3_CBS1585 | cds-NP_014961.3_CBS1585 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:878368-879687:- | gene-YOR316C_CBS436 | rna-NM_001183736.3_CBS436 | cds-NP_014961.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:876251-877569:- | gene-YOR316C_CBS6412 | rna-NM_001183736.3_CBS6412 | cds-NP_014961.3_CBS6412 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:885379-886697:- | gene-YOR316C_CBS6413 | rna-NM_001183736.3_CBS6413 | cds-NP_014961.3_CBS6413 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:906012-907331:- | gene-YOR316C_CENPK1137D | rna-NM_001183736.3_CENPK1137D | cds-NP_014961.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:872641-873959:- | gene-YOR316C_EthanolRed | rna-NM_001183736.3_EthanolRed | cds-NP_014961.3_EthanolRed | 99.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:878264-879582:- | gene-YOR316C_FaliES1 | rna-NM_001183736.3_FaliES1 | cds-NP_014961.3_FaliES1 | 99.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000078.1:123687-125006:+ | gene-YOR316C_JAY291 | rna-NM_001183736.3_JAY291 | cds-NP_014961.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:886375-887694:- | gene-YOR316C_MUCL30387 | rna-NM_001183736.3_MUCL30387 | cds-NP_014961.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:894381-895700:- | gene-YOR316C_MUCL30388 | rna-NM_001183736.3_MUCL30388 | cds-NP_014961.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:887088-888406:- | gene-YOR316C_MUCL39482 | rna-NM_001183736.3_MUCL39482 | cds-NP_014961.3_MUCL39482 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:896555-897874:- | gene-YOR316C_MUCL42920 | rna-NM_001183736.3_MUCL42920 | cds-NP_014961.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:906125-907444:- | gene-YOR316C_NCIM3186 | rna-NM_001183736.3_NCIM3186 | cds-NP_014961.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:888089-889407:- | gene-YOR316C_NCYC1407 | rna-NM_001183736.3_NCYC1407 | cds-NP_014961.3_NCYC1407 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:886310-887629:- | gene-YOR316C_PE2H3 | rna-NM_001183736.3_PE2H3 | cds-NP_014961.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:902662-903981:- | gene-YOR316C_PE2H4 | rna-NM_001183736.3_PE2H4 | cds-NP_014961.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:906236-907555:- | gene-YOR316C_S288C | rna-NM_001183736.3_S288C | cds-NP_014961.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000016.1:16561-17880:- | gene-YOR316C_SA1 | rna-NM_001183736.3_SA1 | cds-NP_014961.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:877447-878765:- | gene-YOR316C_ThermosaccDry | rna-NM_001183736.3_ThermosaccDry | cds-NP_014961.3_ThermosaccDry | 99.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:940732-942051:- | gene-YOR316C_VR1 | rna-NM_001183736.3_VR1 | cds-NP_014961.3_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:610315-611633:- | gene-YOR316C_ZTW1 | rna-NM_001183736.3_ZTW1 | cds-NP_014961.3_ZTW1 | 99.6 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:884611-885930:- | gene-YOR316C_Sparadoxus | rna-NM_001183736.3_Sparadoxus | cds-NP_014961.3_Sparadoxus | 88.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |