Gene name: COS9
Reference locus (S288C): YKL219W
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
Top 10 interactors (score): SRY1 (0.892); YKL223W (0.813); YHL041W (0.811); YHL048C-A (0.811); YHL046W-A (0.811); YPL257W (0.752); PAU16 (0.75); YKL225W (0.749); YHL045W (0.747); MGA1 (0.744); PAU13 (0.744); YKL222C (0.711); YHL049C (0.698); YHL050C (0.693); VHS2 (0.692); RIE1 (0.692); MCH2 (0.657); PAU5 (0.612); FRE2 (0.526); GAT1 (0.483)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000195.1:3763-4988:- | gene-YKL219W_BG1 | rna-NM_001179784.1_BG1 | cds-NP_012703.1_BG1 | 99.1 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:16289-17512:+ | gene-YKL219W_Bruggeman | rna-NM_001179784.1_Bruggeman | cds-NP_012703.1_Bruggeman | 97.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:13149-14372:+ | gene-YKL219W_CAT1 | rna-NM_001179784.1_CAT1 | cds-NP_012703.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:12320-13543:+ | gene-YKL219W_CBS1585 | rna-NM_001179784.1_CBS1585 | cds-NP_012703.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:12048-13271:+ | gene-YKL219W_CBS436 | rna-NM_001179784.1_CBS436 | cds-NP_012703.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:13035-14258:+ | gene-YKL219W_CBS6413 | rna-NM_001179784.1_CBS6413 | cds-NP_012703.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:14327-15550:+ | gene-YKL219W_CENPK1137D | rna-NM_001179784.1_CENPK1137D | cds-NP_012703.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:12674-13897:+ | gene-YKL219W_EthanolRed | rna-NM_001179784.1_EthanolRed | cds-NP_012703.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:12316-13539:+ | gene-YKL219W_FaliES1 | rna-NM_001179784.1_FaliES1 | cds-NP_012703.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:11992-13215:+ | gene-YKL219W_JAY291 | rna-NM_001179784.1_JAY291 | cds-NP_012703.1_JAY291 | 97.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:17189-18356:+ | gene-YKL219W_MUCL30387 | rna-NM_001179784.1_MUCL30387 | cds-NP_012703.1_MUCL30387 | 92.4 | 95.1 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:13963-15186:+ | gene-YKL219W_MUCL30388 | rna-NM_001179784.1_MUCL30388 | cds-NP_012703.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:12399-13622:+ | gene-YKL219W_MUCL39482 | rna-NM_001179784.1_MUCL39482 | cds-NP_012703.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:16149-17372:+ | gene-YKL219W_MUCL42920 | rna-NM_001179784.1_MUCL42920 | cds-NP_012703.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:14474-15697:+ | gene-YKL219W_NCIM3186 | rna-NM_001179784.1_NCIM3186 | cds-NP_012703.1_NCIM3186 | 81.0 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:12433-13656:+ | gene-YKL219W_NCYC1407 | rna-NM_001179784.1_NCYC1407 | cds-NP_012703.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:20609-21832:+ | gene-YKL219W_PE2H3 | rna-NM_001179784.1_PE2H3 | cds-NP_012703.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:16813-18036:+ | gene-YKL219W_PE2H4 | rna-NM_001179784.1_PE2H4 | cds-NP_012703.1_PE2H4 | 97.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:14485-15708:+ | gene-YKL219W_S288C | rna-NM_001179784.1_S288C | cds-NP_012703.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000131.1:5633-6741:+ | gene-YKL219W_SA1 | rna-NM_001179784.1_SA1 | cds-NP_012703.1_SA1 | 89.9 | 90.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:13053-14276:+ | gene-YKL219W_ThermosaccDry | rna-NM_001179784.1_ThermosaccDry | cds-NP_012703.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:11988-13190:+ | gene-YKL219W_VR1 | rna-NM_001179784.1_VR1 | cds-NP_012703.1_VR1 | 91.3 | 95.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:12023-13246:+ | gene-YKL219W_ZTW1 | rna-NM_001179784.1_ZTW1 | cds-NP_012703.1_ZTW1 | 97.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:20852-22086:+ | gene-YKL219W_Sparadoxus | rna-NM_001179784.1_Sparadoxus | cds-NP_012703.1_Sparadoxus | 77.1 | 97.7 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |