Gene name: COS8
Reference locus (S288C): YHL048W
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; Belongs to the DUP/COS family
Top 10 interactors (score): COS2 (0.901); COS4 (0.889); COS3 (0.881); COS1 (0.881); COS7 (0.879); YHL045W (0.858); COS5 (0.816); YHL044W (0.814); YHL049C (0.801); YHL050C (0.777); YHL041W (0.765); YHL048C-A (0.765); YHL046W-A (0.765); YKL223W (0.753); RRT1 (0.749); YAR070C (0.747); YHR218W (0.729); YFL066C (0.727); PAU16 (0.726); YFL067W (0.715)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:1249-2394:+ | gene-YHL048W_AKU4011 | rna-NM_001179128.1_AKU4011 | cds-NP_011815.1_AKU4011 | 89.3 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000130.1:1-1072:- | gene-YHL048W_BG1 | rna-NM_001179128.1_BG1 | cds-NP_011815.1_BG1 | 83.4 | 93.1 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:7661-8806:+ | gene-YHL048W_Bruggeman | rna-NM_001179128.1_Bruggeman | cds-NP_011815.1_Bruggeman | 89.9 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | MBWC01000352.1:93-1238:- | gene-YHL048W_CAT1 | rna-NM_001179128.1_CAT1 | cds-NP_011815.1_CAT1 | 84.0 | 99.3 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:1855-3000:+ | gene-YHL048W_CBS1585 | rna-NM_001179128.1_CBS1585 | cds-NP_011815.1_CBS1585 | 89.6 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:1801-2946:+ | gene-YHL048W_CBS6412 | rna-NM_001179128.1_CBS6412 | cds-NP_011815.1_CBS6412 | 89.7 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:1269-2414:+ | gene-YHL048W_CBS6413 | rna-NM_001179128.1_CBS6413 | cds-NP_011815.1_CBS6413 | 89.3 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001530.1:428732-429876:- | gene-YHL048W_CENPK1137D | rna-NM_001179128.1_CENPK1137D | cds-NP_011815.1_CENPK1137D | 90.2 | 99.6 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:1483-2628:+ | gene-YHL048W_EthanolRed | rna-NM_001179128.1_EthanolRed | cds-NP_011815.1_EthanolRed | 89.4 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:1798-2943:+ | gene-YHL048W_FaliES1 | rna-NM_001179128.1_FaliES1 | cds-NP_011815.1_FaliES1 | 89.4 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000377.1:246-1390:+ | gene-YHL048W_JAY291 | rna-NM_001179128.1_JAY291 | cds-NP_011815.1_JAY291 | 89.3 | 99.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:3721-4866:+ | gene-YHL048W_MUCL30387 | rna-NM_001179128.1_MUCL30387 | cds-NP_011815.1_MUCL30387 | 89.9 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | MBVW01000049.1:14367-15507:- | gene-YHL048W_MUCL30388 | rna-NM_001179128.1_MUCL30388 | cds-NP_011815.1_MUCL30388 | 84.5 | 98.7 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:845-1990:+ | gene-YHL048W_MUCL39482 | rna-NM_001179128.1_MUCL39482 | cds-NP_011815.1_MUCL39482 | 89.3 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005431.1:442988-444263:- | gene-YHL048W_MUCL42920 | rna-NM_001179128.1_MUCL42920 | cds-NP_011815.1_MUCL42920 | 74.0 | 97.0 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:6283-6684:+ | gene-YHL048W_NCIM3186 | rna-NM_001179128.1_NCIM3186 | cds-NP_011815.1_NCIM3186 | 35.0 | 35.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:1-977:+ | gene-YHL048W_NCYC1407 | rna-NM_001179128.1_NCYC1407 | cds-NP_011815.1_NCYC1407 | 76.6 | 84.9 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:81-1226:+ | gene-YHL048W_PE2H3 | rna-NM_001179128.1_PE2H3 | cds-NP_011815.1_PE2H3 | 86.7 | 99.7 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:4006-5151:+ | gene-YHL048W_PE2H4 | rna-NM_001179128.1_PE2H4 | cds-NP_011815.1_PE2H4 | 89.7 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:6401-7546:+ | gene-YHL048W_S288C | rna-NM_001179128.1_S288C | cds-NP_011815.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000129.1:4377-5522:- | gene-YHL048W_SA1 | rna-NM_001179128.1_SA1 | cds-NP_011815.1_SA1 | 89.7 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:2919-4064:+ | gene-YHL048W_ThermosaccDry | rna-NM_001179128.1_ThermosaccDry | cds-NP_011815.1_ThermosaccDry | 89.4 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:5409-6554:+ | gene-YHL048W_VR1 | rna-NM_001179128.1_VR1 | cds-NP_011815.1_VR1 | 89.7 | 99.5 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000020.1:44152-45296:- | gene-YHL048W_ZTW1 | rna-NM_001179128.1_ZTW1 | cds-NP_011815.1_ZTW1 | 89.2 | 99.6 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:285273-286279:- | gene-YHL048W_Sparadoxus | rna-NM_001179128.1_Sparadoxus | cds-NP_011815.1_Sparadoxus | 65.8 | 85.5 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |