Gene name: COS7
Reference locus (S288C): YDL248W
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
Top 10 interactors (score): COS5 (0.887); COS8 (0.879); COS1 (0.872); COS4 (0.872); COS3 (0.858); COS2 (0.852); YDL247W-A (0.84); YAL059C-A (0.813); YAL056C-A (0.813); TDA5 (0.709); SOR2 (0.708); AAD4 (0.695); BDH2 (0.693); MPH2 (0.678); BDH1 (0.671); ECM1 (0.651); HXT15 (0.614); YOR381W-A (0.569); YMR320W (0.569); YHR214C-D (0.565)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:961-2112:+ | gene-YDL248W_AKU4011 | rna-NM_001180308.1_AKU4011 | cds-NP_010033.1_AKU4011 | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:14-1165:+ | gene-YDL248W_Bruggeman | rna-NM_001180308.1_Bruggeman | cds-NP_010033.1_Bruggeman | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:961-2112:+ | gene-YDL248W_CBS1585 | rna-NM_001180308.1_CBS1585 | cds-NP_010033.1_CBS1585 | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:859-2010:+ | gene-YDL248W_CBS436 | rna-NM_001180308.1_CBS436 | cds-NP_010033.1_CBS436 | 98.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:1723-2874:+ | gene-YDL248W_CBS6412 | rna-NM_001180308.1_CBS6412 | cds-NP_010033.1_CBS6412 | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:176-1327:+ | gene-YDL248W_CBS6413 | rna-NM_001180308.1_CBS6413 | cds-NP_010033.1_CBS6413 | 94.0 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | JH711452.1:1229-2226:+ | gene-YDL248W_CENPK1137D | rna-NM_001180308.1_CENPK1137D | cds-NP_010033.1_CENPK1137D | 76.8 | 86.6 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:1474-2625:+ | gene-YDL248W_EthanolRed | rna-NM_001180308.1_EthanolRed | cds-NP_010033.1_EthanolRed | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:1740-2891:+ | gene-YDL248W_FaliES1 | rna-NM_001180308.1_FaliES1 | cds-NP_010033.1_FaliES1 | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1-1090:+ | gene-YDL248W_MUCL30387 | rna-NM_001180308.1_MUCL30387 | cds-NP_010033.1_MUCL30387 | 93.0 | 94.6 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:7163-8314:+ | gene-YDL248W_MUCL30388 | rna-NM_001180308.1_MUCL30388 | cds-NP_010033.1_MUCL30388 | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:1015-2166:+ | gene-YDL248W_MUCL39482 | rna-NM_001180308.1_MUCL39482 | cds-NP_010033.1_MUCL39482 | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1-1042:+ | gene-YDL248W_MUCL42920 | rna-NM_001180308.1_MUCL42920 | cds-NP_010033.1_MUCL42920 | 88.5 | 90.3 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1725-2876:+ | gene-YDL248W_NCIM3186 | rna-NM_001180308.1_NCIM3186 | cds-NP_010033.1_NCIM3186 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | MBVM01000121.1:49-1199:+ | gene-YDL248W_NCYC1407 | rna-NM_001180308.1_NCYC1407 | cds-NP_010033.1_NCYC1407 | 88.7 | 99.4 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1802-2953:+ | gene-YDL248W_S288C | rna-NM_001180308.1_S288C | cds-NP_010033.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000053.1:79968-81119:- | gene-YDL248W_SA1 | rna-NM_001180308.1_SA1 | cds-NP_010033.1_SA1 | 91.4 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:1049-2200:+ | gene-YDL248W_ThermosaccDry | rna-NM_001180308.1_ThermosaccDry | cds-NP_010033.1_ThermosaccDry | 94.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1473-2624:+ | gene-YDL248W_VR1 | rna-NM_001180308.1_VR1 | cds-NP_010033.1_VR1 | 90.4 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000026.1:236-1387:+ | gene-YDL248W_ZTW1 | rna-NM_001180308.1_ZTW1 | cds-NP_010033.1_ZTW1 | 93.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:8811-9956:+ | gene-YDL248W_Sparadoxus | rna-NM_001180308.1_Sparadoxus | cds-NP_010033.1_Sparadoxus | 80.4 | 99.4 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |