Gene name: COS6
Reference locus (S288C): YGR295C
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
Top 10 interactors (score): GEP7 (0.747); CCM1 (0.705); FYV10 (0.696); LAP2 (0.695); EMI2 (0.658); MAL13 (0.607); PRP39 (0.574); MRN1 (0.574); AAC1 (0.572); UBP7 (0.563); COX23 (0.553); COS8 (0.546); RSP5 (0.545); SNA3 (0.526); BSD2 (0.489); YOR302W (0.45)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:9656-11116:+ | gene-YGR295C_Bruggeman | rna-NM_001181424.1_Bruggeman | cds-NP_011811.1_Bruggeman | 73.5 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:10843-11941:+ | gene-YGR295C_CAT1 | rna-NM_001181424.1_CAT1 | cds-NP_011811.1_CAT1 | 88.2 | 95.8 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:1041033-1042432:- | gene-YGR295C_CBS6412 | rna-NM_001181424.1_CBS6412 | cds-NP_011811.1_CBS6412 | 58.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:3-539:+ | gene-YGR295C_CENPK1137D | rna-NM_001181424.1_CENPK1137D | cds-NP_011811.1_CENPK1137D | 45.7 | 46.8 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:812142-812327:- | gene-YGR295C_FaliES1 | rna-NM_001181424.1_FaliES1 | cds-NP_011811.1_FaliES1 | 16.2 | 16.2 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000277.1:1-447:- | gene-YGR295C_JAY291 | rna-NM_001181424.1_JAY291 | cds-NP_011811.1_JAY291 | 34.9 | 38.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:9884-11315:+ | gene-YGR295C_MUCL30387 | rna-NM_001181424.1_MUCL30387 | cds-NP_011811.1_MUCL30387 | 75.0 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:1057003-1058555:- | gene-YGR295C_MUCL30388 | rna-NM_001181424.1_MUCL30388 | cds-NP_011811.1_MUCL30388 | 72.1 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:1043433-1044577:- | gene-YGR295C_MUCL39482 | rna-NM_001181424.1_MUCL39482 | cds-NP_011811.1_MUCL39482 | 61.1 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:1068075-1069123:- | gene-YGR295C_MUCL42920 | rna-NM_001181424.1_MUCL42920 | cds-NP_011811.1_MUCL42920 | 81.6 | 89.6 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:1081584-1082729:- | gene-YGR295C_NCIM3186 | rna-NM_001181424.1_NCIM3186 | cds-NP_011811.1_NCIM3186 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999890.1:9597-10742:- | gene-YGR295C_PE2H4 | rna-NM_001181424.1_PE2H4 | cds-NP_011811.1_PE2H4 | 93.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:1081584-1082729:- | gene-YGR295C_S288C | rna-NM_001181424.1_S288C | cds-NP_011811.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:1060642-1061787:- | gene-YGR295C_ThermosaccDry | rna-NM_001181424.1_ThermosaccDry | cds-NP_011811.1_ThermosaccDry | 59.7 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:1944-3089:+ | gene-YGR295C_Sparadoxus | rna-NM_001181424.1_Sparadoxus | cds-NP_011811.1_Sparadoxus | 82.8 | 99.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |