Gene name: COS5
Reference locus (S288C): YJR161C
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; Belongs to the DUP/COS family
Top 10 interactors (score): COS3 (0.915); COS4 (0.912); COS7 (0.887); COS2 (0.852); COS1 (0.823); COS8 (0.816); SNA3 (0.747); RSP5 (0.712); ROT1 (0.711); TOS6 (0.693); CCW14 (0.692); CWP2 (0.563); TAT2 (0.529); BSD2 (0.526); RPS7B (0.522); SED1 (0.48); RPS7A (0.454)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | MBVO01000063.1:14499-15649:- | gene-YJR161C_AKU4011 | rna-NM_001181819.3_AKU4011 | cds-NP_012695.3_AKU4011 | 89.0 | 99.4 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | MBVY01000337.1:1-1025:+ | gene-YJR161C_Bruggeman | rna-NM_001181819.3_Bruggeman | cds-NP_012695.3_Bruggeman | 80.5 | 88.5 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:735474-736980:- | gene-YJR161C_CAT1 | rna-NM_001181819.3_CAT1 | cds-NP_012695.3_CAT1 | 76.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | MBVS01000092.1:14520-15670:- | gene-YJR161C_CBS1585 | rna-NM_001181819.3_CBS1585 | cds-NP_012695.3_CBS1585 | 89.0 | 99.4 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | MBVQ01000058.1:14180-14906:- | gene-YJR161C_CBS6412 | rna-NM_001181819.3_CBS6412 | cds-NP_012695.3_CBS6412 | 55.9 | 62.6 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | MBVP01000082.1:1716-2866:+ | gene-YJR161C_CBS6413 | rna-NM_001181819.3_CBS6413 | cds-NP_012695.3_CBS6413 | 89.0 | 99.4 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:2529-2908:+ | gene-YJR161C_CENPK1137D | rna-NM_001181819.3_CENPK1137D | cds-NP_012695.3_CENPK1137D | 31.3 | 32.8 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:927499-928654:- | gene-YJR161C_EthanolRed | rna-NM_001181819.3_EthanolRed | cds-NP_012695.3_EthanolRed | 58.1 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:733439-734588:- | gene-YJR161C_FaliES1 | rna-NM_001181819.3_FaliES1 | cds-NP_012695.3_FaliES1 | 66.0 | 87.1 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000429.1:1-162:+ | gene-YJR161C_JAY291 | rna-NM_001181819.3_JAY291 | cds-NP_012695.3_JAY291 | 13.5 | 14.0 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | MBVX01000004.1:20069-20891:- | gene-YJR161C_MUCL30387 | rna-NM_001181819.3_MUCL30387 | cds-NP_012695.3_MUCL30387 | 63.8 | 71.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | MBVW01000082.1:1-629:- | gene-YJR161C_MUCL30388 | rna-NM_001181819.3_MUCL30388 | cds-NP_012695.3_MUCL30388 | 52.1 | 54.6 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | MBVN01000012.1:1-453:- | gene-YJR161C_MUCL39482 | rna-NM_001181819.3_MUCL39482 | cds-NP_012695.3_MUCL39482 | 37.6 | 39.3 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:742827-743978:- | gene-YJR161C_NCIM3186 | rna-NM_001181819.3_NCIM3186 | cds-NP_012695.3_NCIM3186 | 93.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:1767-2918:+ | gene-YJR161C_NCYC1407 | rna-NM_001181819.3_NCYC1407 | cds-NP_012695.3_NCYC1407 | 93.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:708049-709136:- | gene-YJR161C_PE2H3 | rna-NM_001181819.3_PE2H3 | cds-NP_012695.3_PE2H3 | 72.2 | 87.2 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:81-1232:+ | gene-YJR161C_PE2H4 | rna-NM_001181819.3_PE2H4 | cds-NP_012695.3_PE2H4 | 88.6 | 98.9 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:742848-743999:- | gene-YJR161C_S288C | rna-NM_001181819.3_S288C | cds-NP_012695.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | MBWA01000091.1:14156-15086:- | gene-YJR161C_ThermosaccDry | rna-NM_001181819.3_ThermosaccDry | cds-NP_012695.3_ThermosaccDry | 73.0 | 80.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:11831-12982:+ | gene-YJR161C_VR1 | rna-NM_001181819.3_VR1 | cds-NP_012695.3_VR1 | 88.4 | 98.9 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:731613-732758:- | gene-YJR161C_Sparadoxus | rna-NM_001181819.3_Sparadoxus | cds-NP_012695.3_Sparadoxus | 80.2 | 99.4 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |