Gene name: COS4
Reference locus (S288C): YFL062W
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
Top 10 interactors (score): COS1 (0.988); COS2 (0.975); COS3 (0.928); COS5 (0.912); YLR379W (0.896); COS8 (0.889); COS7 (0.872); RRT1 (0.78); CSR1 (0.617); THI5 (0.612); MOH1 (0.612); THI11 (0.574); MPA43 (0.569); YJL132W (0.526); SNA3 (0.499); BSD2 (0.481); YNR066C (0.45); RSP5 (0.405)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005303.1:436108-437247:- | gene-YFL062W_AKU4011 | rna-NM_001179905.1_AKU4011 | cds-NP_116593.1_AKU4011 | 59.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000105.1:1-565:+ | gene-YFL062W_BG1 | rna-NM_001179905.1_BG1 | cds-NP_116593.1_BG1 | 48.7 | 49.5 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:929-2070:+ | gene-YFL062W_Bruggeman | rna-NM_001179905.1_Bruggeman | cds-NP_116593.1_Bruggeman | 80.2 | 99.3 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:1060273-1061412:- | gene-YFL062W_CAT1 | rna-NM_001179905.1_CAT1 | cds-NP_116593.1_CAT1 | 52.1 | 100.0 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:1615-2696:+ | gene-YFL062W_CBS6412 | rna-NM_001179905.1_CBS6412 | cds-NP_116593.1_CBS6412 | 75.4 | 90.5 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:3334-3687:+ | gene-YFL062W_CENPK1137D | rna-NM_001179905.1_CENPK1137D | cds-NP_116593.1_CENPK1137D | 31.0 | 31.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | MBWD01000106.1:1-932:- | gene-YFL062W_FaliES1 | rna-NM_001179905.1_FaliES1 | cds-NP_116593.1_FaliES1 | 77.7 | 81.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:800660-801427:- | gene-YFL062W_MUCL30387 | rna-NM_001179905.1_MUCL30387 | cds-NP_116593.1_MUCL30387 | 66.9 | 67.3 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:4764-5899:+ | gene-YFL062W_MUCL30388 | rna-NM_001179905.1_MUCL30388 | cds-NP_116593.1_MUCL30388 | 68.5 | 99.1 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:1-872:+ | gene-YFL062W_MUCL39482 | rna-NM_001179905.1_MUCL39482 | cds-NP_116593.1_MUCL39482 | 72.9 | 75.9 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:1-782:+ | gene-YFL062W_MUCL42920 | rna-NM_001179905.1_MUCL42920 | cds-NP_116593.1_MUCL42920 | 53.4 | 67.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994148.1:436804-437949:- | gene-YFL062W_PE2H3 | rna-NM_001179905.1_PE2H3 | cds-NP_116593.1_PE2H3 | 92.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:1094919-1096049:- | gene-YFL062W_PE2H4 | rna-NM_001179905.1_PE2H4 | cds-NP_116593.1_PE2H4 | 64.8 | 85.3 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:6426-7565:+ | gene-YFL062W_S288C | rna-NM_001179905.1_S288C | cds-NP_116593.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | MBWA01000045.1:1-657:- | gene-YFL062W_ThermosaccDry | rna-NM_001179905.1_ThermosaccDry | cds-NP_116593.1_ThermosaccDry | 55.7 | 57.6 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:6027-6591:+ | gene-YFL062W_VR1 | rna-NM_001179905.1_VR1 | cds-NP_116593.1_VR1 | 48.1 | 49.5 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:988-2136:+ | gene-YFL062W_ZTW1 | rna-NM_001179905.1_ZTW1 | cds-NP_116593.1_ZTW1 | 89.3 | 98.8 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:936117-937255:- | gene-YFL062W_Sparadoxus | rna-NM_001179905.1_Sparadoxus | cds-NP_116593.1_Sparadoxus | 80.7 | 98.9 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |