COS3 (YML132W)

Gene profile

Gene name: COS3
Reference locus (S288C): YML132W
Gene biotype: protein_coding

Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

Top 10 interactors (score): COS2 (0.988); COS4 (0.928); COS1 (0.927); COS5 (0.915); COS8 (0.881); COS7 (0.858); YML079W (0.78); NHA1 (0.742); YFL064C (0.71); CSS3 (0.709); YML133C (0.672); YJL225C (0.671); TPO4 (0.617); YBL111C (0.574); YHL049C (0.574); CYC2 (0.552); YRF1-7 (0.513); CIP1 (0.499); YPL283W-A (0.499); THI13 (0.497)

Homologues (species, bitscore): Unknown

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser

Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
BG1 GCA_001932575.1 Bioethanol South America MSHP01000201.1:475031-475595:- gene-YML132W_BG1 rna-NM_001182495.1_BG1 cds-NP_013574.1_BG1 49.3 49.5 Mismatch 1 1 0 False False True False False
CAT1 GCA_001738705.1 Bioethanol South America CM005531.1:8240-9379:+ gene-YML132W_CAT1 rna-NM_001182495.1_CAT1 cds-NP_013574.1_CAT1 63.6 100.0 Mismatch 1 1 0 False False True False False
CBS436 GCA_001738355.1 Sake Asia CM005356.1:2969-4088:+ gene-YML132W_CBS436 rna-NM_001182495.1_CBS436 cds-NP_013574.1_CBS436 94.9 98.2 Mismatch 1 1 0 False False True False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005477.1:1035305-1036444:- gene-YML132W_EthanolRed rna-NM_001182495.1_EthanolRed cds-NP_013574.1_EthanolRed 61.2 100.0 Mismatch 1 1 0 False False False True False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005544.1:732249-733394:- gene-YML132W_FaliES1 rna-NM_001182495.1_FaliES1 cds-NP_013574.1_FaliES1 86.7 98.9 Mismatch 1 1 0 False False False True False
MUCL30387 GCA_001738515.1 Bread Europe CM005419.1:5159-6395:+ gene-YML132W_MUCL30387 rna-NM_001182495.1_MUCL30387 cds-NP_013574.1_MUCL30387 89.5 100.0 Unannotated 1 1 0 False False False True False
MUCL30388 GCA_001738495.1 Bread Europe MBVW01000213.1:91-1101:+ gene-YML132W_MUCL30388 rna-NM_001182495.1_MUCL30388 cds-NP_013574.1_MUCL30388 87.4 88.6 Mismatch 1 1 0 False False False True False
MUCL42920 GCA_001738485.1 Bread Europe CM005435.1:2378-3516:+ gene-YML132W_MUCL42920 rna-NM_001182495.1_MUCL42920 cds-NP_013574.1_MUCL42920 91.0 97.2 Unannotated 1 1 0 False False False False True
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011815.1:6425-7564:+ gene-YML132W_NCIM3186 rna-NM_001182495.1_NCIM3186 cds-NP_013574.1_NCIM3186 77.5 100.0 Mismatch 1 1 1 False True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994152.1:7149-8288:+ gene-YML132W_PE2H3 rna-NM_001182495.1_PE2H3 cds-NP_013574.1_PE2H3 99.3 100.0 Mismatch 1 1 1 False True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999884.1:7087-8226:+ gene-YML132W_PE2H4 rna-NM_001182495.1_PE2H4 cds-NP_013574.1_PE2H4 99.2 100.0 Mismatch 1 1 1 False True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001145.3:7244-8383:+ gene-YML132W_S288C rna-NM_001182495.1_S288C cds-NP_013574.1_S288C 100.0 100.0 Mismatch 1 1 1 True True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005468.1:10672-11706:+ gene-YML132W_VR1 rna-NM_001182495.1_VR1 cds-NP_013574.1_VR1 81.3 89.7 Unannotated 1 1 0 False False False True False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047493.1:1986-3124:+ gene-YML132W_Sparadoxus rna-NM_001182495.1_Sparadoxus cds-NP_013574.1_Sparadoxus 78.2 99.0 Unannotated 1 1 0 False False False False True

Additional files