Gene name: COS12
Reference locus (S288C): YGL263W
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins
Top 10 interactors (score): YGL262W (0.969); PAU11 (0.746); YOL163W (0.745); YOL162W (0.745); YOL166W-A (0.744); YGL258W-A (0.744); AAD15 (0.713); YFR057W (0.699); PAU20 (0.695); SEO1 (0.695); YIR042C (0.694); YGL260W (0.693); PRM6 (0.691); YER039C-A (0.651); YOL131W (0.651); PAU4 (0.619); ANS1 (0.596); ASF2 (0.573); RKM4 (0.572); SIR1 (0.572)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:2700-3842:+ | gene-YGL263W_AKU4011 | rna-NM_001181129.1_AKU4011 | cds-NP_011251.1_AKU4011 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:4080-5222:+ | gene-YGL263W_Bruggeman | rna-NM_001181129.1_Bruggeman | cds-NP_011251.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:2591-3733:+ | gene-YGL263W_CAT1 | rna-NM_001181129.1_CAT1 | cds-NP_011251.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:2553-3695:+ | gene-YGL263W_CBS1585 | rna-NM_001181129.1_CBS1585 | cds-NP_011251.1_CBS1585 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS436 | GCA_001738355.1 | Sake | Asia | MBVR01000049.1:25209-26351:+ | gene-YGL263W_CBS436 | rna-NM_001181129.1_CBS436 | cds-NP_011251.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | MBVQ01000083.1:4824-5966:+ | gene-YGL263W_CBS6412 | rna-NM_001181129.1_CBS6412 | cds-NP_011251.1_CBS6412 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:2579-3721:+ | gene-YGL263W_CBS6413 | rna-NM_001181129.1_CBS6413 | cds-NP_011251.1_CBS6413 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:2621-3764:+ | gene-YGL263W_CENPK1137D | rna-NM_001181129.1_CENPK1137D | cds-NP_011251.1_CENPK1137D | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000340.1:1976-3118:+ | gene-YGL263W_JAY291 | rna-NM_001181129.1_JAY291 | cds-NP_011251.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:4015-5157:+ | gene-YGL263W_MUCL30387 | rna-NM_001181129.1_MUCL30387 | cds-NP_011251.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:1465-2607:+ | gene-YGL263W_MUCL30388 | rna-NM_001181129.1_MUCL30388 | cds-NP_011251.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:3570-4712:+ | gene-YGL263W_MUCL39482 | rna-NM_001181129.1_MUCL39482 | cds-NP_011251.1_MUCL39482 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:5649-6791:+ | gene-YGL263W_MUCL42920 | rna-NM_001181129.1_MUCL42920 | cds-NP_011251.1_MUCL42920 | 99.5 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:2790-3932:+ | gene-YGL263W_NCIM3186 | rna-NM_001181129.1_NCIM3186 | cds-NP_011251.1_NCIM3186 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:2392-3534:+ | gene-YGL263W_NCYC1407 | rna-NM_001181129.1_NCYC1407 | cds-NP_011251.1_NCYC1407 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:3208-4350:+ | gene-YGL263W_PE2H3 | rna-NM_001181129.1_PE2H3 | cds-NP_011251.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:3005-4147:+ | gene-YGL263W_PE2H4 | rna-NM_001181129.1_PE2H4 | cds-NP_011251.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:2790-3932:+ | gene-YGL263W_S288C | rna-NM_001181129.1_S288C | cds-NP_011251.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000047.1:2837-3979:+ | gene-YGL263W_SA1 | rna-NM_001181129.1_SA1 | cds-NP_011251.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:8728-9879:+ | gene-YGL263W_Sparadoxus | rna-NM_001181129.1_Sparadoxus | cds-NP_011251.1_Sparadoxus | 64.7 | 94.0 | Unannotated | 1 | 1 | 0 | False | False | True | False | False |