Gene name: COS10
Reference locus (S288C): YNR075W
Gene biotype: protein_coding
Description: Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; Belongs to the DUP/COS family
Top 10 interactors (score): PAU20 (0.692); YER039C-A (0.619); VTH1 (0.618); PAU11 (0.579); RTC4 (0.573); SVL3 (0.572); YPT35 (0.572); ASF2 (0.571); YHK8 (0.569); SDS24 (0.565); DDI3 (0.563); YIL165C (0.56); HVG1 (0.56); VTH2 (0.527); BDS1 (0.526); YOR387C (0.526); YOL162W (0.525); YOL163W (0.524); PAU6 (0.521); PAU18 (0.511)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:1109-1287:- | gene-YNR075W_AKU4011 | rna-NM_001183252.1_AKU4011 | cds-NP_014473.1_AKU4011 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000029.1:580-1704:+ | gene-YNR075W_BG1 | rna-NM_001183252.1_BG1 | cds-NP_014473.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:776057-777181:+ | gene-YNR075W_Bruggeman | rna-NM_001183252.1_Bruggeman | cds-NP_014473.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:818307-819431:+ | gene-YNR075W_CAT1 | rna-NM_001183252.1_CAT1 | cds-NP_014473.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:7271-7449:- | gene-YNR075W_CBS1585 | rna-NM_001183252.1_CBS1585 | cds-NP_014473.1_CBS1585 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:831701-832825:+ | gene-YNR075W_CBS436 | rna-NM_001183252.1_CBS436 | cds-NP_014473.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | MBVQ01000083.1:9560-9738:- | gene-YNR075W_CBS6412 | rna-NM_001183252.1_CBS6412 | cds-NP_014473.1_CBS6412 | 13.9 | 15.9 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:1472-1650:- | gene-YNR075W_CBS6413 | rna-NM_001183252.1_CBS6413 | cds-NP_014473.1_CBS6413 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:759921-761045:+ | gene-YNR075W_CENPK1137D | rna-NM_001183252.1_CENPK1137D | cds-NP_014473.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:973-1151:- | gene-YNR075W_EthanolRed | rna-NM_001183252.1_EthanolRed | cds-NP_014473.1_EthanolRed | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:1640-1818:- | gene-YNR075W_FaliES1 | rna-NM_001183252.1_FaliES1 | cds-NP_014473.1_FaliES1 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000031.1:335-1459:- | gene-YNR075W_JAY291 | rna-NM_001183252.1_JAY291 | cds-NP_014473.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:766161-767285:+ | gene-YNR075W_MUCL30387 | rna-NM_001183252.1_MUCL30387 | cds-NP_014473.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:812679-813803:+ | gene-YNR075W_MUCL30388 | rna-NM_001183252.1_MUCL30388 | cds-NP_014473.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:914-1092:- | gene-YNR075W_MUCL39482 | rna-NM_001183252.1_MUCL39482 | cds-NP_014473.1_MUCL39482 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:762022-763146:+ | gene-YNR075W_MUCL42920 | rna-NM_001183252.1_MUCL42920 | cds-NP_014473.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:12682-12850:- | gene-YNR075W_NCIM3186 | rna-NM_001183252.1_NCIM3186 | cds-NP_014473.1_NCIM3186 | 13.3 | 15.0 | Mismatch | 1 | 1 | 0 | False | False | True | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:7134-7312:- | gene-YNR075W_NCYC1407 | rna-NM_001183252.1_NCYC1407 | cds-NP_014473.1_NCYC1407 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:764369-765493:+ | gene-YNR075W_PE2H3 | rna-NM_001183252.1_PE2H3 | cds-NP_014473.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:765757-766881:+ | gene-YNR075W_PE2H4 | rna-NM_001183252.1_PE2H4 | cds-NP_014473.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:779916-781040:+ | gene-YNR075W_S288C | rna-NM_001183252.1_S288C | cds-NP_014473.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000168.1:680-1804:+ | gene-YNR075W_SA1 | rna-NM_001183252.1_SA1 | cds-NP_014473.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:1178-1356:- | gene-YNR075W_ThermosaccDry | rna-NM_001183252.1_ThermosaccDry | cds-NP_014473.1_ThermosaccDry | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:799237-800360:+ | gene-YNR075W_VR1 | rna-NM_001183252.1_VR1 | cds-NP_014473.1_VR1 | 99.9 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:943-1121:- | gene-YNR075W_ZTW1 | rna-NM_001183252.1_ZTW1 | cds-NP_014473.1_ZTW1 | 13.9 | 15.9 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:769211-770338:+ | gene-YNR075W_Sparadoxus | rna-NM_001183252.1_Sparadoxus | cds-NP_014473.1_Sparadoxus | 82.0 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |