COQ8 (YGL119W)


Gene profile

Gene name: COQ8
Reference locus (S288C): YGL119W
Gene biotype: protein_coding

Description: Atypical kinase COQ8, mitochondrial; ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2

Top 10 interactors (score): COQ9 (0.998); COQ6 (0.998); COQ2 (0.997); COQ5 (0.997); COQ3 (0.997); COQ4 (0.996); CAT5 (0.996); COQ1 (0.993); COQ10 (0.971); YAH1 (0.93); ATP2 (0.899); FMO1 (0.898); COQ11 (0.871); CBS2 (0.822); YPL109C (0.818); COB (0.777); DDL1 (0.761); ATX1 (0.751); COX15 (0.694); CIR2 (0.684)

Homologues (species, bitscore): ADCK3 (Homo sapiens, 381.7); Adck4 (Mus musculus, 384.4); adck4 (Danio rerio, 409.5); adck4 (Xenopus tropicalis, 396.0); CG32649 (Drosophila melanogaster, 392.5); coq-8 (Caenorhabditis elegans, 357.1); ABC1 (Arabidopsis thaliana, 356.7)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005301.1:287191-288696:+ gene-YGL119W_AKU4011 rna-NM_001180984.1_AKU4011 cds-NP_011396.1_AKU4011 99.2 100.0 Verified 1 1 1 False True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000132.1:116469-117974:- gene-YGL119W_BG1 rna-NM_001180984.1_BG1 cds-NP_011396.1_BG1 99.6 100.0 Verified 1 1 1 True True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005509.1:289933-291438:+ gene-YGL119W_Bruggeman rna-NM_001180984.1_Bruggeman cds-NP_011396.1_Bruggeman 99.8 100.0 Verified 1 1 1 False True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005525.1:285454-286959:+ gene-YGL119W_CAT1 rna-NM_001180984.1_CAT1 cds-NP_011396.1_CAT1 99.7 100.0 Verified 1 1 1 True True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005365.1:290517-292022:+ gene-YGL119W_CBS1585 rna-NM_001180984.1_CBS1585 cds-NP_011396.1_CBS1585 99.2 100.0 Verified 1 1 1 False True False False False
CBS436 GCA_001738355.1 Sake Asia CM005349.1:285406-286911:+ gene-YGL119W_CBS436 rna-NM_001180984.1_CBS436 cds-NP_011396.1_CBS436 99.9 100.0 Mismatch 1 1 1 True True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005333.1:275794-277299:+ gene-YGL119W_CBS6412 rna-NM_001180984.1_CBS6412 cds-NP_011396.1_CBS6412 99.2 100.0 Mismatch 1 1 1 False True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005317.1:285394-286899:+ gene-YGL119W_CBS6413 rna-NM_001180984.1_CBS6413 cds-NP_011396.1_CBS6413 99.2 100.0 Verified 1 1 1 False True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001528.1:284629-286134:+ gene-YGL119W_CENPK1137D rna-NM_001180984.1_CENPK1137D cds-NP_011396.1_CENPK1137D 100.0 100.0 Verified 1 1 1 True True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005477.1:276713-278218:+ gene-YGL119W_EthanolRed rna-NM_001180984.1_EthanolRed cds-NP_011396.1_EthanolRed 99.2 100.0 Verified 1 1 1 False True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005541.1:278894-280399:+ gene-YGL119W_FaliES1 rna-NM_001180984.1_FaliES1 cds-NP_011396.1_FaliES1 99.2 100.0 Verified 1 1 1 False True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000046.1:21240-22745:- gene-YGL119W_JAY291 rna-NM_001180984.1_JAY291 cds-NP_011396.1_JAY291 99.6 100.0 Verified 1 1 1 True True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005413.1:286903-288408:+ gene-YGL119W_MUCL30387 rna-NM_001180984.1_MUCL30387 cds-NP_011396.1_MUCL30387 99.8 100.0 Verified 1 1 1 False True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005445.1:289995-291500:+ gene-YGL119W_MUCL30388 rna-NM_001180984.1_MUCL30388 cds-NP_011396.1_MUCL30388 99.8 100.0 Verified 1 1 1 False True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005285.1:287614-289119:+ gene-YGL119W_MUCL39482 rna-NM_001180984.1_MUCL39482 cds-NP_011396.1_MUCL39482 99.2 100.0 Verified 1 1 1 False True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005429.1:290895-292400:+ gene-YGL119W_MUCL42920 rna-NM_001180984.1_MUCL42920 cds-NP_011396.1_MUCL42920 99.9 100.0 Verified 1 1 1 True True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011816.1:284442-285947:+ gene-YGL119W_NCIM3186 rna-NM_001180984.1_NCIM3186 cds-NP_011396.1_NCIM3186 99.6 100.0 Verified 1 1 1 False True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005269.1:279104-280609:+ gene-YGL119W_NCYC1407 rna-NM_001180984.1_NCYC1407 cds-NP_011396.1_NCYC1407 99.1 100.0 Verified 1 1 1 False True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994146.1:280485-281990:+ gene-YGL119W_PE2H3 rna-NM_001180984.1_PE2H3 cds-NP_011396.1_PE2H3 99.6 100.0 Verified 1 1 1 True True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999878.1:285483-286988:+ gene-YGL119W_PE2H4 rna-NM_001180984.1_PE2H4 cds-NP_011396.1_PE2H4 99.6 100.0 Verified 1 1 1 True True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001139.9:284442-285947:+ gene-YGL119W_S288C rna-NM_001180984.1_S288C cds-NP_011396.1_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000064.1:29238-30743:+ gene-YGL119W_SA1 rna-NM_001180984.1_SA1 cds-NP_011396.1_SA1 99.6 100.0 Verified 1 1 1 False True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005493.1:279106-280611:+ gene-YGL119W_ThermosaccDry rna-NM_001180984.1_ThermosaccDry cds-NP_011396.1_ThermosaccDry 99.2 100.0 Verified 1 1 1 False True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005461.1:389212-390717:+ gene-YGL119W_VR1 rna-NM_001180984.1_VR1 cds-NP_011396.1_VR1 99.8 100.0 Verified 1 1 1 True True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000014.1:276674-278179:+ gene-YGL119W_ZTW1 rna-NM_001180984.1_ZTW1 cds-NP_011396.1_ZTW1 99.2 100.0 Verified 1 1 1 False True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047493.1:282682-284187:+ gene-YGL119W_Sparadoxus rna-NM_001180984.1_Sparadoxus cds-NP_011396.1_Sparadoxus 90.2 99.8 Verified 1 1 1 False True False False False

Additional files