Gene name: COQ8
Reference locus (S288C): YGL119W
Gene biotype: protein_coding
Description: Atypical kinase COQ8, mitochondrial; ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2
Top 10 interactors (score): COQ9 (0.998); COQ6 (0.998); COQ2 (0.997); COQ5 (0.997); COQ3 (0.997); COQ4 (0.996); CAT5 (0.996); COQ1 (0.993); COQ10 (0.971); YAH1 (0.93); ATP2 (0.899); FMO1 (0.898); COQ11 (0.871); CBS2 (0.822); YPL109C (0.818); COB (0.777); DDL1 (0.761); ATX1 (0.751); COX15 (0.694); CIR2 (0.684)
Homologues (species, bitscore): ADCK3 (Homo sapiens, 381.7); Adck4 (Mus musculus, 384.4); adck4 (Danio rerio, 409.5); adck4 (Xenopus tropicalis, 396.0); CG32649 (Drosophila melanogaster, 392.5); coq-8 (Caenorhabditis elegans, 357.1); ABC1 (Arabidopsis thaliana, 356.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:287191-288696:+ | gene-YGL119W_AKU4011 | rna-NM_001180984.1_AKU4011 | cds-NP_011396.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:116469-117974:- | gene-YGL119W_BG1 | rna-NM_001180984.1_BG1 | cds-NP_011396.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:289933-291438:+ | gene-YGL119W_Bruggeman | rna-NM_001180984.1_Bruggeman | cds-NP_011396.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:285454-286959:+ | gene-YGL119W_CAT1 | rna-NM_001180984.1_CAT1 | cds-NP_011396.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:290517-292022:+ | gene-YGL119W_CBS1585 | rna-NM_001180984.1_CBS1585 | cds-NP_011396.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:285406-286911:+ | gene-YGL119W_CBS436 | rna-NM_001180984.1_CBS436 | cds-NP_011396.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:275794-277299:+ | gene-YGL119W_CBS6412 | rna-NM_001180984.1_CBS6412 | cds-NP_011396.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:285394-286899:+ | gene-YGL119W_CBS6413 | rna-NM_001180984.1_CBS6413 | cds-NP_011396.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:284629-286134:+ | gene-YGL119W_CENPK1137D | rna-NM_001180984.1_CENPK1137D | cds-NP_011396.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:276713-278218:+ | gene-YGL119W_EthanolRed | rna-NM_001180984.1_EthanolRed | cds-NP_011396.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:278894-280399:+ | gene-YGL119W_FaliES1 | rna-NM_001180984.1_FaliES1 | cds-NP_011396.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000046.1:21240-22745:- | gene-YGL119W_JAY291 | rna-NM_001180984.1_JAY291 | cds-NP_011396.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:286903-288408:+ | gene-YGL119W_MUCL30387 | rna-NM_001180984.1_MUCL30387 | cds-NP_011396.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:289995-291500:+ | gene-YGL119W_MUCL30388 | rna-NM_001180984.1_MUCL30388 | cds-NP_011396.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:287614-289119:+ | gene-YGL119W_MUCL39482 | rna-NM_001180984.1_MUCL39482 | cds-NP_011396.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:290895-292400:+ | gene-YGL119W_MUCL42920 | rna-NM_001180984.1_MUCL42920 | cds-NP_011396.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:284442-285947:+ | gene-YGL119W_NCIM3186 | rna-NM_001180984.1_NCIM3186 | cds-NP_011396.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:279104-280609:+ | gene-YGL119W_NCYC1407 | rna-NM_001180984.1_NCYC1407 | cds-NP_011396.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:280485-281990:+ | gene-YGL119W_PE2H3 | rna-NM_001180984.1_PE2H3 | cds-NP_011396.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:285483-286988:+ | gene-YGL119W_PE2H4 | rna-NM_001180984.1_PE2H4 | cds-NP_011396.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:284442-285947:+ | gene-YGL119W_S288C | rna-NM_001180984.1_S288C | cds-NP_011396.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000064.1:29238-30743:+ | gene-YGL119W_SA1 | rna-NM_001180984.1_SA1 | cds-NP_011396.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:279106-280611:+ | gene-YGL119W_ThermosaccDry | rna-NM_001180984.1_ThermosaccDry | cds-NP_011396.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:389212-390717:+ | gene-YGL119W_VR1 | rna-NM_001180984.1_VR1 | cds-NP_011396.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:276674-278179:+ | gene-YGL119W_ZTW1 | rna-NM_001180984.1_ZTW1 | cds-NP_011396.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:282682-284187:+ | gene-YGL119W_Sparadoxus | rna-NM_001180984.1_Sparadoxus | cds-NP_011396.1_Sparadoxus | 90.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |