Gene name: COM2
Reference locus (S288C): YER130C
Gene biotype: protein_coding
Description: Zinc finger protein YER130C; Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress
Top 10 interactors (score): STP4 (0.768); HAA1 (0.7); TPO2 (0.695); YPR015C (0.676); TDA6 (0.674); YGP1 (0.671); TPO3 (0.581); SDD4 (0.572); MNC1 (0.563); IME1 (0.548); MRPL19 (0.543); SLT2 (0.537); YLL053C (0.532); YLR462W (0.525); SKO1 (0.523); VPS62 (0.502); YER135C (0.499); YPL067C (0.494); CMR3 (0.489); STB6 (0.488)
Homologues (species, bitscore): EGR1 (Homo sapiens, 76.3); Egr1 (Mus musculus, 76.3); egr1 (Danio rerio, 76.3); egr1 (Xenopus tropicalis, 76.6); sr (Drosophila melanogaster, 72.8); egrh-1 (Caenorhabditis elegans, 66.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:414949-416280:- | gene-YER130C_AKU4011 | rna-NM_001179020.1_AKU4011 | cds-NP_011056.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:9375-10706:+ | gene-YER130C_BG1 | rna-NM_001179020.1_BG1 | cds-NP_011056.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:425415-426746:- | gene-YER130C_Bruggeman | rna-NM_001179020.1_Bruggeman | cds-NP_011056.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:420655-421986:- | gene-YER130C_CAT1 | rna-NM_001179020.1_CAT1 | cds-NP_011056.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:414344-415675:- | gene-YER130C_CBS1585 | rna-NM_001179020.1_CBS1585 | cds-NP_011056.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:417091-418422:- | gene-YER130C_CBS436 | rna-NM_001179020.1_CBS436 | cds-NP_011056.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:413422-414753:- | gene-YER130C_CBS6412 | rna-NM_001179020.1_CBS6412 | cds-NP_011056.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:420265-421596:- | gene-YER130C_CBS6413 | rna-NM_001179020.1_CBS6413 | cds-NP_011056.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:418837-420168:- | gene-YER130C_CENPK1137D | rna-NM_001179020.1_CENPK1137D | cds-NP_011056.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:414793-416124:- | gene-YER130C_EthanolRed | rna-NM_001179020.1_EthanolRed | cds-NP_011056.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:415274-416605:- | gene-YER130C_FaliES1 | rna-NM_001179020.1_FaliES1 | cds-NP_011056.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000028.1:23538-24869:- | gene-YER130C_JAY291 | rna-NM_001179020.1_JAY291 | cds-NP_011056.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:422364-423695:- | gene-YER130C_MUCL30387 | rna-NM_001179020.1_MUCL30387 | cds-NP_011056.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:417310-418641:- | gene-YER130C_MUCL30388 | rna-NM_001179020.1_MUCL30388 | cds-NP_011056.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:413369-414700:- | gene-YER130C_MUCL39482 | rna-NM_001179020.1_MUCL39482 | cds-NP_011056.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:421856-423187:- | gene-YER130C_MUCL42920 | rna-NM_001179020.1_MUCL42920 | cds-NP_011056.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:421114-422445:- | gene-YER130C_NCIM3186 | rna-NM_001179020.1_NCIM3186 | cds-NP_011056.1_NCIM3186 | 93.2 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:418902-420233:- | gene-YER130C_NCYC1407 | rna-NM_001179020.1_NCYC1407 | cds-NP_011056.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:429489-430820:- | gene-YER130C_PE2H3 | rna-NM_001179020.1_PE2H3 | cds-NP_011056.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:419430-420761:- | gene-YER130C_PE2H4 | rna-NM_001179020.1_PE2H4 | cds-NP_011056.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:421115-422446:- | gene-YER130C_S288C | rna-NM_001179020.1_S288C | cds-NP_011056.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:130672-132003:- | gene-YER130C_SA1 | rna-NM_001179020.1_SA1 | cds-NP_011056.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:416072-417403:- | gene-YER130C_ThermosaccDry | rna-NM_001179020.1_ThermosaccDry | cds-NP_011056.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:417123-418454:- | gene-YER130C_VR1 | rna-NM_001179020.1_VR1 | cds-NP_011056.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:413201-414532:- | gene-YER130C_ZTW1 | rna-NM_001179020.1_ZTW1 | cds-NP_011056.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:417060-418415:- | gene-YER130C_Sparadoxus | rna-NM_001179020.1_Sparadoxus | cds-NP_011056.1_Sparadoxus | 85.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |