Gene name: COF1
Reference locus (S288C): YLL050C
Gene biotype: protein_coding
Description: Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes; Belongs to the actin-binding proteins ADF family
Top 10 interactors (score): PFY1 (0.999); SRV2 (0.999); AIP1 (0.999); ACT1 (0.999); CRN1 (0.996); ARP2 (0.995); SAC6 (0.994); TWF1 (0.991); TPM1 (0.987); TPM2 (0.983); ARP1 (0.979); ARP9 (0.977); AIM7 (0.977); LAS17 (0.974); ABP1 (0.968); ARP3 (0.963); PRM15 (0.963); ADE12 (0.962); ADO1 (0.96); ADH4 (0.96)
Homologues (species, bitscore): CFL1 (Homo sapiens, 104.0); Cfl1 (Mus musculus, 104.0); cfl2 (Danio rerio, 100.9); cfl2 (Xenopus tropicalis, 95.9); tsr (Drosophila melanogaster, 99.4); unc-60 (Caenorhabditis elegans, 67.8); ADF6 (Arabidopsis thaliana, 124.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:26970-27580:- | gene-YLL050C_AKU4011 | rna-NM_001181870.1_AKU4011 | cds-NP_013050.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000204.1:830-1440:+ | gene-YLL050C_BG1 | rna-NM_001181870.1_BG1 | cds-NP_013050.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:36333-36943:- | gene-YLL050C_Bruggeman | rna-NM_001181870.1_Bruggeman | cds-NP_013050.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:37815-38425:- | gene-YLL050C_CAT1 | rna-NM_001181870.1_CAT1 | cds-NP_013050.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:34869-35479:- | gene-YLL050C_CBS1585 | rna-NM_001181870.1_CBS1585 | cds-NP_013050.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:24894-25504:- | gene-YLL050C_CBS436 | rna-NM_001181870.1_CBS436 | cds-NP_013050.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:34915-35525:- | gene-YLL050C_CBS6412 | rna-NM_001181870.1_CBS6412 | cds-NP_013050.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:34678-35288:- | gene-YLL050C_CBS6413 | rna-NM_001181870.1_CBS6413 | cds-NP_013050.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:24755-25365:- | gene-YLL050C_CENPK1137D | rna-NM_001181870.1_CENPK1137D | cds-NP_013050.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:27783-28393:- | gene-YLL050C_EthanolRed | rna-NM_001181870.1_EthanolRed | cds-NP_013050.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:26872-27482:- | gene-YLL050C_FaliES1 | rna-NM_001181870.1_FaliES1 | cds-NP_013050.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000073.1:26017-26627:- | gene-YLL050C_JAY291 | rna-NM_001181870.1_JAY291 | cds-NP_013050.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:34641-35251:- | gene-YLL050C_MUCL30387 | rna-NM_001181870.1_MUCL30387 | cds-NP_013050.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:38645-39255:- | gene-YLL050C_MUCL30388 | rna-NM_001181870.1_MUCL30388 | cds-NP_013050.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:34871-35481:- | gene-YLL050C_MUCL39482 | rna-NM_001181870.1_MUCL39482 | cds-NP_013050.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:35201-35811:- | gene-YLL050C_MUCL42920 | rna-NM_001181870.1_MUCL42920 | cds-NP_013050.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:39778-40388:- | gene-YLL050C_NCIM3186 | rna-NM_001181870.1_NCIM3186 | cds-NP_013050.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:26711-27321:- | gene-YLL050C_NCYC1407 | rna-NM_001181870.1_NCYC1407 | cds-NP_013050.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:33423-34033:- | gene-YLL050C_PE2H3 | rna-NM_001181870.1_PE2H3 | cds-NP_013050.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:33226-33836:- | gene-YLL050C_PE2H4 | rna-NM_001181870.1_PE2H4 | cds-NP_013050.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:39804-40414:- | gene-YLL050C_S288C | rna-NM_001181870.1_S288C | cds-NP_013050.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000047.1:33056-33666:- | gene-YLL050C_SA1 | rna-NM_001181870.1_SA1 | cds-NP_013050.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:27407-28017:- | gene-YLL050C_ThermosaccDry | rna-NM_001181870.1_ThermosaccDry | cds-NP_013050.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:40992-41602:- | gene-YLL050C_VR1 | rna-NM_001181870.1_VR1 | cds-NP_013050.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:26733-27343:- | gene-YLL050C_ZTW1 | rna-NM_001181870.1_ZTW1 | cds-NP_013050.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:35107-35719:- | gene-YLL050C_Sparadoxus | rna-NM_001181870.1_Sparadoxus | cds-NP_013050.1_Sparadoxus | 94.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |