Gene name: CNS1
Reference locus (S288C): YBR155W
Gene biotype: protein_coding
Description: Hsp70/Hsp90 co-chaperone CNS1; TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant; Belongs to the TTC4 family
Top 10 interactors (score): HGH1 (0.998); CPR7 (0.996); HSC82 (0.993); HSP82 (0.991); CPR6 (0.983); SBA1 (0.942); NOP4 (0.937); EBP2 (0.932); BFR2 (0.927); LCP5 (0.924); ENP2 (0.924); CDC37 (0.903); AHA1 (0.901); ROK1 (0.897); RRS1 (0.895); RPF2 (0.894); UTP14 (0.891); NOP14 (0.885); HCH1 (0.885); RRP14 (0.878)
Homologues (species, bitscore): TTC4 (Homo sapiens, 93.6); Ttc4 (Mus musculus, 94.7); ttc4 (Danio rerio, 83.6); ttc4 (Xenopus tropicalis, 85.9); Dpit47 (Drosophila melanogaster, 90.9); C17G10.2 (Caenorhabditis elegans, 119.8); AT1G04130 (Arabidopsis thaliana, 92.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:532655-533812:+ | gene-YBR155W_AKU4011 | rna-NM_001178503.1_AKU4011 | cds-NP_009713.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:523219-524376:+ | gene-YBR155W_BG1 | rna-NM_001178503.1_BG1 | cds-NP_009713.1_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:535692-536849:+ | gene-YBR155W_Bruggeman | rna-NM_001178503.1_Bruggeman | cds-NP_009713.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:429793-430950:+ | gene-YBR155W_CAT1 | rna-NM_001178503.1_CAT1 | cds-NP_009713.1_CAT1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:524434-525591:+ | gene-YBR155W_CBS1585 | rna-NM_001178503.1_CBS1585 | cds-NP_009713.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:532526-533683:+ | gene-YBR155W_CBS436 | rna-NM_001178503.1_CBS436 | cds-NP_009713.1_CBS436 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:622300-623457:+ | gene-YBR155W_CBS6412 | rna-NM_001178503.1_CBS6412 | cds-NP_009713.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:530069-531226:+ | gene-YBR155W_CBS6413 | rna-NM_001178503.1_CBS6413 | cds-NP_009713.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:543539-544696:+ | gene-YBR155W_CENPK1137D | rna-NM_001178503.1_CENPK1137D | cds-NP_009713.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:658675-659832:+ | gene-YBR155W_EthanolRed | rna-NM_001178503.1_EthanolRed | cds-NP_009713.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:548687-549844:+ | gene-YBR155W_FaliES1 | rna-NM_001178503.1_FaliES1 | cds-NP_009713.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000322.1:10321-11478:- | gene-YBR155W_JAY291 | rna-NM_001178503.1_JAY291 | cds-NP_009713.1_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:537319-538476:+ | gene-YBR155W_MUCL30387 | rna-NM_001178503.1_MUCL30387 | cds-NP_009713.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:536612-537769:+ | gene-YBR155W_MUCL30388 | rna-NM_001178503.1_MUCL30388 | cds-NP_009713.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:522821-523978:+ | gene-YBR155W_MUCL39482 | rna-NM_001178503.1_MUCL39482 | cds-NP_009713.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:532712-533869:+ | gene-YBR155W_MUCL42920 | rna-NM_001178503.1_MUCL42920 | cds-NP_009713.1_MUCL42920 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:549568-550725:+ | gene-YBR155W_NCIM3186 | rna-NM_001178503.1_NCIM3186 | cds-NP_009713.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:525371-526528:+ | gene-YBR155W_NCYC1407 | rna-NM_001178503.1_NCYC1407 | cds-NP_009713.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:538003-539160:+ | gene-YBR155W_PE2H3 | rna-NM_001178503.1_PE2H3 | cds-NP_009713.1_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:535679-536836:+ | gene-YBR155W_PE2H4 | rna-NM_001178503.1_PE2H4 | cds-NP_009713.1_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:549771-550928:+ | gene-YBR155W_S288C | rna-NM_001178503.1_S288C | cds-NP_009713.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:70948-72105:+ | gene-YBR155W_SA1 | rna-NM_001178503.1_SA1 | cds-NP_009713.1_SA1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:547700-548857:+ | gene-YBR155W_ThermosaccDry | rna-NM_001178503.1_ThermosaccDry | cds-NP_009713.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:529194-530351:+ | gene-YBR155W_VR1 | rna-NM_001178503.1_VR1 | cds-NP_009713.1_VR1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:522846-524003:+ | gene-YBR155W_ZTW1 | rna-NM_001178503.1_ZTW1 | cds-NP_009713.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:559993-561150:+ | gene-YBR155W_Sparadoxus | rna-NM_001178503.1_Sparadoxus | cds-NP_009713.1_Sparadoxus | 89.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |