Gene name: CLN3
Reference locus (S288C): YAL040C
Gene biotype: protein_coding
Description: G1/S-specific cyclin CLN3; G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1
Top 10 interactors (score): CDC28 (0.999); WHI5 (0.997); SWI4 (0.996); SWI6 (0.993); WHI3 (0.989); BCK2 (0.986); FAR1 (0.966); CLN2 (0.954); MBP1 (0.943); SIC1 (0.938); PHO85 (0.934); CLB5 (0.925); CDC20 (0.914); SWE1 (0.913); CDC4 (0.902); CLB2 (0.891); CDC6 (0.89); YDJ1 (0.869); CLB1 (0.86); CLN1 (0.857)
Homologues (species, bitscore): CCNO (Homo sapiens, 51.2); ccnb2 (Danio rerio, 52.0); ccno (Xenopus tropicalis, 55.1); CycB (Drosophila melanogaster, 60.8); cyb-2.2 (Caenorhabditis elegans, 64.3); CYCB1;3 (Arabidopsis thaliana, 67.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005295.1:50922-52664:- | gene-YAL040C_AKU4011 | rna-NM_001178185.1_AKU4011 | cds-NP_009360.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000070.1:37991-39733:- | gene-YAL040C_BG1 | rna-NM_001178185.1_BG1 | cds-NP_009360.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005503.1:65381-67123:- | gene-YAL040C_Bruggeman | rna-NM_001178185.1_Bruggeman | cds-NP_009360.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005519.1:52141-53883:- | gene-YAL040C_CAT1 | rna-NM_001178185.1_CAT1 | cds-NP_009360.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005359.1:63941-65683:- | gene-YAL040C_CBS1585 | rna-NM_001178185.1_CBS1585 | cds-NP_009360.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005343.1:64184-65926:- | gene-YAL040C_CBS436 | rna-NM_001178185.1_CBS436 | cds-NP_009360.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005327.1:50087-51829:- | gene-YAL040C_CBS6412 | rna-NM_001178185.1_CBS6412 | cds-NP_009360.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005311.1:62205-63947:- | gene-YAL040C_CBS6413 | rna-NM_001178185.1_CBS6413 | cds-NP_009360.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001522.1:65840-67582:- | gene-YAL040C_CENPK1137D | rna-NM_001178185.1_CENPK1137D | cds-NP_009360.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005471.1:52335-54077:- | gene-YAL040C_EthanolRed | rna-NM_001178185.1_EthanolRed | cds-NP_009360.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005535.1:66277-68019:- | gene-YAL040C_FaliES1 | rna-NM_001178185.1_FaliES1 | cds-NP_009360.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000084.1:38229-39971:- | gene-YAL040C_JAY291 | rna-NM_001178185.1_JAY291 | cds-NP_009360.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005407.1:66890-68632:- | gene-YAL040C_MUCL30387 | rna-NM_001178185.1_MUCL30387 | cds-NP_009360.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005439.1:63431-65173:- | gene-YAL040C_MUCL30388 | rna-NM_001178185.1_MUCL30388 | cds-NP_009360.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005279.1:62746-64488:- | gene-YAL040C_MUCL39482 | rna-NM_001178185.1_MUCL39482 | cds-NP_009360.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005423.1:65094-66836:- | gene-YAL040C_MUCL42920 | rna-NM_001178185.1_MUCL42920 | cds-NP_009360.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011810.1:65655-67397:- | gene-YAL040C_NCIM3186 | rna-NM_001178185.1_NCIM3186 | cds-NP_009360.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005263.1:50611-52353:- | gene-YAL040C_NCYC1407 | rna-NM_001178185.1_NCYC1407 | cds-NP_009360.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994140.1:52494-54236:- | gene-YAL040C_PE2H3 | rna-NM_001178185.1_PE2H3 | cds-NP_009360.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999872.1:52213-53955:- | gene-YAL040C_PE2H4 | rna-NM_001178185.1_PE2H4 | cds-NP_009360.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001133.9:65778-67520:- | gene-YAL040C_S288C | rna-NM_001178185.1_S288C | cds-NP_009360.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000084.1:40388-42130:- | gene-YAL040C_SA1 | rna-NM_001178185.1_SA1 | cds-NP_009360.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005487.1:66487-68229:- | gene-YAL040C_ThermosaccDry | rna-NM_001178185.1_ThermosaccDry | cds-NP_009360.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005455.1:67755-69497:- | gene-YAL040C_VR1 | rna-NM_001178185.1_VR1 | cds-NP_009360.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000002.1:38295-40037:- | gene-YAL040C_ZTW1 | rna-NM_001178185.1_ZTW1 | cds-NP_009360.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047487.1:55971-57710:- | gene-YAL040C_Sparadoxus | rna-NM_001178185.1_Sparadoxus | cds-NP_009360.1_Sparadoxus | 93.9 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |