Gene name: CLN2
Reference locus (S288C): YPL256C
Gene biotype: protein_coding
Description: G1/S-specific cyclin CLN2; G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1
Top 10 interactors (score): CDC28 (0.999); FAR1 (0.996); CKS1 (0.996); GRR1 (0.993); CLN1 (0.991); SIC1 (0.986); SWI6 (0.985); PHO85 (0.983); WHI5 (0.977); SKP1 (0.974); SWI4 (0.968); CDC53 (0.963); CLN3 (0.954); CLB1 (0.953); CTK2 (0.948); STE20 (0.923); CTK1 (0.921); PCL6 (0.918); CDC4 (0.911); PHO80 (0.91)
Homologues (species, bitscore): ccna1 (Danio rerio, 51.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:42721-44358:- | gene-YPL256C_AKU4011 | rna-NM_001184070.1_AKU4011 | cds-NP_015067.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000184.1:30833-32470:+ | gene-YPL256C_BG1 | rna-NM_001184070.1_BG1 | cds-NP_015067.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:66610-68247:- | gene-YPL256C_Bruggeman | rna-NM_001184070.1_Bruggeman | cds-NP_015067.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:64732-66369:- | gene-YPL256C_CAT1 | rna-NM_001184070.1_CAT1 | cds-NP_015067.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:47031-48668:- | gene-YPL256C_CBS1585 | rna-NM_001184070.1_CBS1585 | cds-NP_015067.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:61468-63105:- | gene-YPL256C_CBS436 | rna-NM_001184070.1_CBS436 | cds-NP_015067.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:52196-53833:- | gene-YPL256C_CBS6412 | rna-NM_001184070.1_CBS6412 | cds-NP_015067.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:43183-44820:- | gene-YPL256C_CBS6413 | rna-NM_001184070.1_CBS6413 | cds-NP_015067.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:64915-66552:- | gene-YPL256C_CENPK1137D | rna-NM_001184070.1_CENPK1137D | cds-NP_015067.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:42134-43771:- | gene-YPL256C_EthanolRed | rna-NM_001184070.1_EthanolRed | cds-NP_015067.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:48941-50578:- | gene-YPL256C_FaliES1 | rna-NM_001184070.1_FaliES1 | cds-NP_015067.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000264.1:30173-31810:+ | gene-YPL256C_JAY291 | rna-NM_001184070.1_JAY291 | cds-NP_015067.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:59774-61411:- | gene-YPL256C_MUCL30387 | rna-NM_001184070.1_MUCL30387 | cds-NP_015067.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:58219-59856:- | gene-YPL256C_MUCL30388 | rna-NM_001184070.1_MUCL30388 | cds-NP_015067.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:40161-41798:- | gene-YPL256C_MUCL39482 | rna-NM_001184070.1_MUCL39482 | cds-NP_015067.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:59045-60682:- | gene-YPL256C_MUCL42920 | rna-NM_001184070.1_MUCL42920 | cds-NP_015067.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:64960-66597:- | gene-YPL256C_NCIM3186 | rna-NM_001184070.1_NCIM3186 | cds-NP_015067.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:46608-48245:- | gene-YPL256C_NCYC1407 | rna-NM_001184070.1_NCYC1407 | cds-NP_015067.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:54346-55983:- | gene-YPL256C_PE2H3 | rna-NM_001184070.1_PE2H3 | cds-NP_015067.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:53990-55627:- | gene-YPL256C_PE2H4 | rna-NM_001184070.1_PE2H4 | cds-NP_015067.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:64977-66614:- | gene-YPL256C_S288C | rna-NM_001184070.1_S288C | cds-NP_015067.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000056.1:6868-8505:- | gene-YPL256C_SA1 | rna-NM_001184070.1_SA1 | cds-NP_015067.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:48942-50579:- | gene-YPL256C_ThermosaccDry | rna-NM_001184070.1_ThermosaccDry | cds-NP_015067.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:288822-290459:- | gene-YPL256C_VR1 | rna-NM_001184070.1_VR1 | cds-NP_015067.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:48486-50123:- | gene-YPL256C_ZTW1 | rna-NM_001184070.1_ZTW1 | cds-NP_015067.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:50071-51711:- | gene-YPL256C_Sparadoxus | rna-NM_001184070.1_Sparadoxus | cds-NP_015067.1_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |