Gene name: CLA4
Reference locus (S288C): YNL298W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase CLA4; Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
Top 10 interactors (score): BEM1 (0.999); CDC42 (0.999); CDC24 (0.993); STE20 (0.985); GIC1 (0.979); SLT2 (0.977); GIC2 (0.968); HOG1 (0.954); STE11 (0.954); MYO1 (0.949); RGA1 (0.948); RHO1 (0.946); SMK1 (0.94); CDC12 (0.934); STE4 (0.926); BNI1 (0.916); SPA2 (0.915); BEM3 (0.915); MLC1 (0.914); MLC2 (0.914)
Homologues (species, bitscore): PAK1 (Homo sapiens, 342.4); Pak1 (Mus musculus, 353.2); ENSDARP00000006253 (Danio rerio, 340.1); pak3 (Xenopus tropicalis, 344.4); Pak (Drosophila melanogaster, 348.2); pak-1 (Caenorhabditis elegans, 331.6); SIK1 (Arabidopsis thaliana, 204.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:62728-65256:+ | gene-YNL298W_AKU4011 | rna-NM_001183136.1_AKU4011 | cds-NP_014101.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:25388-27916:- | gene-YNL298W_BG1 | rna-NM_001183136.1_BG1 | cds-NP_014101.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:72071-74602:+ | gene-YNL298W_Bruggeman | rna-NM_001183136.1_Bruggeman | cds-NP_014101.1_Bruggeman | 99.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:74679-77207:+ | gene-YNL298W_CAT1 | rna-NM_001183136.1_CAT1 | cds-NP_014101.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:63059-65587:+ | gene-YNL298W_CBS1585 | rna-NM_001183136.1_CBS1585 | cds-NP_014101.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:63549-66077:+ | gene-YNL298W_CBS436 | rna-NM_001183136.1_CBS436 | cds-NP_014101.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:59719-62244:+ | gene-YNL298W_CBS6412 | rna-NM_001183136.1_CBS6412 | cds-NP_014101.1_CBS6412 | 99.6 | 99.8 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:59907-62435:+ | gene-YNL298W_CBS6413 | rna-NM_001183136.1_CBS6413 | cds-NP_014101.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:62748-65276:+ | gene-YNL298W_CENPK1137D | rna-NM_001183136.1_CENPK1137D | cds-NP_014101.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:59750-62275:+ | gene-YNL298W_EthanolRed | rna-NM_001183136.1_EthanolRed | cds-NP_014101.1_EthanolRed | 99.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:60649-63174:+ | gene-YNL298W_FaliES1 | rna-NM_001183136.1_FaliES1 | cds-NP_014101.1_FaliES1 | 99.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000171.1:25044-27569:- | gene-YNL298W_JAY291 | rna-NM_001183136.1_JAY291 | cds-NP_014101.1_JAY291 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:72322-74853:+ | gene-YNL298W_MUCL30387 | rna-NM_001183136.1_MUCL30387 | cds-NP_014101.1_MUCL30387 | 99.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:65354-67882:+ | gene-YNL298W_MUCL30388 | rna-NM_001183136.1_MUCL30388 | cds-NP_014101.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:60696-63221:+ | gene-YNL298W_MUCL39482 | rna-NM_001183136.1_MUCL39482 | cds-NP_014101.1_MUCL39482 | 99.6 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:62385-64913:+ | gene-YNL298W_MUCL42920 | rna-NM_001183136.1_MUCL42920 | cds-NP_014101.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:68884-71412:+ | gene-YNL298W_NCIM3186 | rna-NM_001183136.1_NCIM3186 | cds-NP_014101.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:62028-64553:+ | gene-YNL298W_NCYC1407 | rna-NM_001183136.1_NCYC1407 | cds-NP_014101.1_NCYC1407 | 99.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:59227-61752:+ | gene-YNL298W_PE2H3 | rna-NM_001183136.1_PE2H3 | cds-NP_014101.1_PE2H3 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:58615-61140:+ | gene-YNL298W_PE2H4 | rna-NM_001183136.1_PE2H4 | cds-NP_014101.1_PE2H4 | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:68915-71443:+ | gene-YNL298W_S288C | rna-NM_001183136.1_S288C | cds-NP_014101.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:25774-28302:- | gene-YNL298W_SA1 | rna-NM_001183136.1_SA1 | cds-NP_014101.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:61506-64031:+ | gene-YNL298W_ThermosaccDry | rna-NM_001183136.1_ThermosaccDry | cds-NP_014101.1_ThermosaccDry | 99.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:74044-76572:+ | gene-YNL298W_VR1 | rna-NM_001183136.1_VR1 | cds-NP_014101.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:52718-55243:+ | gene-YNL298W_ZTW1 | rna-NM_001183136.1_ZTW1 | cds-NP_014101.1_ZTW1 | 99.5 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:70793-73306:+ | gene-YNL298W_Sparadoxus | rna-NM_001183136.1_Sparadoxus | cds-NP_014101.1_Sparadoxus | 90.5 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |