Gene name: CKS1
Reference locus (S288C): YBR135W
Gene biotype: protein_coding
Description: Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant
Top 10 interactors (score): CDC28 (0.999); PHO85 (0.999); SKP1 (0.998); CLB2 (0.998); CLB1 (0.998); CLB3 (0.997); CLN2 (0.996); CAK1 (0.993); CLB4 (0.982); CLB5 (0.979); CLN1 (0.976); SIC1 (0.972); MPS1 (0.966); CTK2 (0.957); SWE1 (0.955); UBC12 (0.953); CDC53 (0.953); HRT1 (0.95); IPL1 (0.95); HTZ1 (0.946)
Homologues (species, bitscore): CKS2 (Homo sapiens, 88.6); Cks2 (Mus musculus, 89.4); cks2 (Danio rerio, 96.7); cks2 (Xenopus tropicalis, 96.3); Cks85A (Drosophila melanogaster, 87.4); Y71G12B.27 (Caenorhabditis elegans, 92.8); CKS2 (Arabidopsis thaliana, 97.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:487742-488194:+ | gene-YBR135W_AKU4011 | rna-NM_001178483.3_AKU4011 | cds-NP_009693.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:478310-478762:+ | gene-YBR135W_BG1 | rna-NM_001178483.3_BG1 | cds-NP_009693.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:489546-489998:+ | gene-YBR135W_Bruggeman | rna-NM_001178483.3_Bruggeman | cds-NP_009693.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:384885-385337:+ | gene-YBR135W_CAT1 | rna-NM_001178483.3_CAT1 | cds-NP_009693.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:479522-479974:+ | gene-YBR135W_CBS1585 | rna-NM_001178483.3_CBS1585 | cds-NP_009693.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:487632-488084:+ | gene-YBR135W_CBS436 | rna-NM_001178483.3_CBS436 | cds-NP_009693.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:577388-577840:+ | gene-YBR135W_CBS6412 | rna-NM_001178483.3_CBS6412 | cds-NP_009693.3_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:485157-485609:+ | gene-YBR135W_CBS6413 | rna-NM_001178483.3_CBS6413 | cds-NP_009693.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:498625-499077:+ | gene-YBR135W_CENPK1137D | rna-NM_001178483.3_CENPK1137D | cds-NP_009693.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:613763-614215:+ | gene-YBR135W_EthanolRed | rna-NM_001178483.3_EthanolRed | cds-NP_009693.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:503775-504227:+ | gene-YBR135W_FaliES1 | rna-NM_001178483.3_FaliES1 | cds-NP_009693.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000444.1:27233-27685:+ | gene-YBR135W_JAY291 | rna-NM_001178483.3_JAY291 | cds-NP_009693.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:492420-492872:+ | gene-YBR135W_MUCL30387 | rna-NM_001178483.3_MUCL30387 | cds-NP_009693.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:491708-492160:+ | gene-YBR135W_MUCL30388 | rna-NM_001178483.3_MUCL30388 | cds-NP_009693.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:477909-478361:+ | gene-YBR135W_MUCL39482 | rna-NM_001178483.3_MUCL39482 | cds-NP_009693.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:487811-488263:+ | gene-YBR135W_MUCL42920 | rna-NM_001178483.3_MUCL42920 | cds-NP_009693.3_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:504651-505103:+ | gene-YBR135W_NCIM3186 | rna-NM_001178483.3_NCIM3186 | cds-NP_009693.3_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:480448-480900:+ | gene-YBR135W_NCYC1407 | rna-NM_001178483.3_NCYC1407 | cds-NP_009693.3_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:493078-493530:+ | gene-YBR135W_PE2H3 | rna-NM_001178483.3_PE2H3 | cds-NP_009693.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:490754-491206:+ | gene-YBR135W_PE2H4 | rna-NM_001178483.3_PE2H4 | cds-NP_009693.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:504854-505306:+ | gene-YBR135W_S288C | rna-NM_001178483.3_S288C | cds-NP_009693.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:26035-26487:+ | gene-YBR135W_SA1 | rna-NM_001178483.3_SA1 | cds-NP_009693.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:502788-503240:+ | gene-YBR135W_ThermosaccDry | rna-NM_001178483.3_ThermosaccDry | cds-NP_009693.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:484284-484736:+ | gene-YBR135W_VR1 | rna-NM_001178483.3_VR1 | cds-NP_009693.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:477936-478388:+ | gene-YBR135W_ZTW1 | rna-NM_001178483.3_ZTW1 | cds-NP_009693.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:515172-515609:+ | gene-YBR135W_Sparadoxus | rna-NM_001178483.3_Sparadoxus | cds-NP_009693.3_Sparadoxus | 89.8 | 96.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |