Gene name: CIT2
Reference locus (S288C): YCR005C
Gene biotype: protein_coding
Description: Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication
Top 10 interactors (score): ACO1 (0.998); MDH1 (0.998); MDH3 (0.996); CIT1 (0.995); IDH2 (0.995); MLS1 (0.994); MDH2 (0.993); ACS1 (0.993); LAT1 (0.989); ACS2 (0.988); PYC1 (0.987); FUM1 (0.986); ACO2 (0.983); DAL7 (0.983); IDH1 (0.981); PYC2 (0.975); LSC1 (0.969); DLD3 (0.967); PDB1 (0.967); PCK1 (0.964)
Homologues (species, bitscore): CS (Homo sapiens, 568.5); Cs (Mus musculus, 562.0); cs (Danio rerio, 568.2); cs (Xenopus tropicalis, 558.9); kdn (Drosophila melanogaster, 556.2); cts-1 (Caenorhabditis elegans, 538.9); ATCS (Arabidopsis thaliana, 524.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:115655-117037:- | gene-YCR005C_AKU4011 | rna-NM_001178718.1_AKU4011 | cds-NP_009931.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000178.1:28993-30375:+ | gene-YCR005C_BG1 | rna-NM_001178718.1_BG1 | cds-NP_009931.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:111469-112851:- | gene-YCR005C_Bruggeman | rna-NM_001178718.1_Bruggeman | cds-NP_009931.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:115987-117369:- | gene-YCR005C_CAT1 | rna-NM_001178718.1_CAT1 | cds-NP_009931.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:116304-117686:- | gene-YCR005C_CBS1585 | rna-NM_001178718.1_CBS1585 | cds-NP_009931.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:121229-122611:- | gene-YCR005C_CBS436 | rna-NM_001178718.1_CBS436 | cds-NP_009931.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:103764-105146:- | gene-YCR005C_CBS6412 | rna-NM_001178718.1_CBS6412 | cds-NP_009931.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:115611-116993:- | gene-YCR005C_CBS6413 | rna-NM_001178718.1_CBS6413 | cds-NP_009931.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:120421-121803:- | gene-YCR005C_CENPK1137D | rna-NM_001178718.1_CENPK1137D | cds-NP_009931.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:113673-115055:- | gene-YCR005C_EthanolRed | rna-NM_001178718.1_EthanolRed | cds-NP_009931.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:115971-117353:- | gene-YCR005C_FaliES1 | rna-NM_001178718.1_FaliES1 | cds-NP_009931.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000126.1:30144-31526:- | gene-YCR005C_JAY291 | rna-NM_001178718.1_JAY291 | cds-NP_009931.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:108686-110068:- | gene-YCR005C_MUCL30387 | rna-NM_001178718.1_MUCL30387 | cds-NP_009931.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:108244-109626:- | gene-YCR005C_MUCL30388 | rna-NM_001178718.1_MUCL30388 | cds-NP_009931.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:116721-118103:- | gene-YCR005C_MUCL39482 | rna-NM_001178718.1_MUCL39482 | cds-NP_009931.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:111961-113343:- | gene-YCR005C_MUCL42920 | rna-NM_001178718.1_MUCL42920 | cds-NP_009931.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:120578-121960:- | gene-YCR005C_NCIM3186 | rna-NM_001178718.1_NCIM3186 | cds-NP_009931.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:117204-118586:- | gene-YCR005C_NCYC1407 | rna-NM_001178718.1_NCYC1407 | cds-NP_009931.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:121376-122758:- | gene-YCR005C_PE2H3 | rna-NM_001178718.1_PE2H3 | cds-NP_009931.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:121340-122722:- | gene-YCR005C_PE2H4 | rna-NM_001178718.1_PE2H4 | cds-NP_009931.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:120946-122328:- | gene-YCR005C_S288C | rna-NM_001178718.1_S288C | cds-NP_009931.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000073.1:29005-30387:+ | gene-YCR005C_SA1 | rna-NM_001178718.1_SA1 | cds-NP_009931.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:116539-117921:- | gene-YCR005C_ThermosaccDry | rna-NM_001178718.1_ThermosaccDry | cds-NP_009931.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:127211-128593:- | gene-YCR005C_VR1 | rna-NM_001178718.1_VR1 | cds-NP_009931.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:115475-116857:- | gene-YCR005C_ZTW1 | rna-NM_001178718.1_ZTW1 | cds-NP_009931.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:146359-147741:- | gene-YCR005C_Sparadoxus | rna-NM_001178718.1_Sparadoxus | cds-NP_009931.1_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |