Gene name: CHK1
Reference locus (S288C): YBR274W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase CHK1; Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
Top 10 interactors (score): CDC45 (0.999); RAD53 (0.999); MCM4 (0.999); MEC1 (0.999); MIH1 (0.999); RAD9 (0.999); TEL1 (0.998); RAD51 (0.998); SGS1 (0.997); DUN1 (0.995); CDC9 (0.995); DPB11 (0.995); CDC6 (0.993); MCM2 (0.993); TOF1 (0.993); RAD24 (0.992); ORC1 (0.992); CSM3 (0.991); EXO1 (0.989); POL2 (0.988)
Homologues (species, bitscore): CHEK1 (Homo sapiens, 181.0); Chek1 (Mus musculus, 176.0); chek1 (Danio rerio, 183.0); chek1 (Xenopus tropicalis, 186.8); grp (Drosophila melanogaster, 187.2); chk-1 (Caenorhabditis elegans, 179.5); CIPK3 (Arabidopsis thaliana, 171.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:733873-735456:+ | gene-YBR274W_AKU4011 | rna-NM_001178622.1_AKU4011 | cds-NP_009833.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:104892-106475:+ | gene-YBR274W_BG1 | rna-NM_001178622.1_BG1 | cds-NP_009833.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:735031-736614:+ | gene-YBR274W_Bruggeman | rna-NM_001178622.1_Bruggeman | cds-NP_009833.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:738758-740341:+ | gene-YBR274W_CAT1 | rna-NM_001178622.1_CAT1 | cds-NP_009833.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:725439-727022:+ | gene-YBR274W_CBS1585 | rna-NM_001178622.1_CBS1585 | cds-NP_009833.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:731879-733462:+ | gene-YBR274W_CBS436 | rna-NM_001178622.1_CBS436 | cds-NP_009833.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:820054-821637:+ | gene-YBR274W_CBS6412 | rna-NM_001178622.1_CBS6412 | cds-NP_009833.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:731487-733070:+ | gene-YBR274W_CBS6413 | rna-NM_001178622.1_CBS6413 | cds-NP_009833.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:743494-745077:+ | gene-YBR274W_CENPK1137D | rna-NM_001178622.1_CENPK1137D | cds-NP_009833.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:856908-858491:+ | gene-YBR274W_EthanolRed | rna-NM_001178622.1_EthanolRed | cds-NP_009833.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:750255-751838:+ | gene-YBR274W_FaliES1 | rna-NM_001178622.1_FaliES1 | cds-NP_009833.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000067.1:52224-53807:- | gene-YBR274W_JAY291 | rna-NM_001178622.1_JAY291 | cds-NP_009833.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:737074-738657:+ | gene-YBR274W_MUCL30387 | rna-NM_001178622.1_MUCL30387 | cds-NP_009833.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:754156-755739:+ | gene-YBR274W_MUCL30388 | rna-NM_001178622.1_MUCL30388 | cds-NP_009833.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:723746-725329:+ | gene-YBR274W_MUCL39482 | rna-NM_001178622.1_MUCL39482 | cds-NP_009833.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:733612-735195:+ | gene-YBR274W_MUCL42920 | rna-NM_001178622.1_MUCL42920 | cds-NP_009833.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:749391-750974:+ | gene-YBR274W_NCIM3186 | rna-NM_001178622.1_NCIM3186 | cds-NP_009833.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:725635-727218:+ | gene-YBR274W_NCYC1407 | rna-NM_001178622.1_NCYC1407 | cds-NP_009833.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:748760-750343:+ | gene-YBR274W_PE2H3 | rna-NM_001178622.1_PE2H3 | cds-NP_009833.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:746436-748019:+ | gene-YBR274W_PE2H4 | rna-NM_001178622.1_PE2H4 | cds-NP_009833.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:749594-751177:+ | gene-YBR274W_S288C | rna-NM_001178622.1_S288C | cds-NP_009833.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:104714-106297:+ | gene-YBR274W_SA1 | rna-NM_001178622.1_SA1 | cds-NP_009833.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:749247-750830:+ | gene-YBR274W_ThermosaccDry | rna-NM_001178622.1_ThermosaccDry | cds-NP_009833.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:729458-731041:+ | gene-YBR274W_VR1 | rna-NM_001178622.1_VR1 | cds-NP_009833.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:722091-723674:+ | gene-YBR274W_ZTW1 | rna-NM_001178622.1_ZTW1 | cds-NP_009833.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:766007-767590:+ | gene-YBR274W_Sparadoxus | rna-NM_001178622.1_Sparadoxus | cds-NP_009833.1_Sparadoxus | 90.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |