Gene name: CDC73
Reference locus (S288C): YLR418C
Gene biotype: protein_coding
Description: Cell division control protein 73; Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers; Belongs to the CDC73 family
Top 10 interactors (score): SKI8 (0.999); RTF1 (0.999); PAF1 (0.999); RPO21 (0.999); LEO1 (0.999); SPT5 (0.999); CTR9 (0.999); SPT16 (0.996); SPT4 (0.99); DST1 (0.989); SPT6 (0.985); POB3 (0.984); RPB2 (0.972); SSN3 (0.968); BRE1 (0.958); RPB3 (0.953); HTZ1 (0.95); RPB7 (0.948); RPO26 (0.94); TAF14 (0.939)
Homologues (species, bitscore): CDC73 (Homo sapiens, 87.0); Cdc73 (Mus musculus, 87.0); cdc73 (Danio rerio, 84.3); cdc73 (Xenopus tropicalis, 89.0); hyx (Drosophila melanogaster, 90.5); F35F11.1 (Caenorhabditis elegans, 83.2); PHP (Arabidopsis thaliana, 111.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:900465-901646:- | gene-YLR418C_AKU4011 | rna-NM_001182306.1_AKU4011 | cds-NP_013522.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:132629-133810:- | gene-YLR418C_BG1 | rna-NM_001182306.1_BG1 | cds-NP_013522.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:938771-939952:- | gene-YLR418C_Bruggeman | rna-NM_001182306.1_Bruggeman | cds-NP_013522.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:934314-935495:- | gene-YLR418C_CAT1 | rna-NM_001182306.1_CAT1 | cds-NP_013522.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:936061-937242:- | gene-YLR418C_CBS1585 | rna-NM_001182306.1_CBS1585 | cds-NP_013522.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:919718-920899:- | gene-YLR418C_CBS436 | rna-NM_001182306.1_CBS436 | cds-NP_013522.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:972102-973283:- | gene-YLR418C_CBS6412 | rna-NM_001182306.1_CBS6412 | cds-NP_013522.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:936353-937534:- | gene-YLR418C_CBS6413 | rna-NM_001182306.1_CBS6413 | cds-NP_013522.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:935777-936958:- | gene-YLR418C_CENPK1137D | rna-NM_001182306.1_CENPK1137D | cds-NP_013522.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:893011-894192:- | gene-YLR418C_EthanolRed | rna-NM_001182306.1_EthanolRed | cds-NP_013522.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:922321-923502:- | gene-YLR418C_FaliES1 | rna-NM_001182306.1_FaliES1 | cds-NP_013522.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:75458-76639:- | gene-YLR418C_JAY291 | rna-NM_001182306.1_JAY291 | cds-NP_013522.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:937636-938817:- | gene-YLR418C_MUCL30387 | rna-NM_001182306.1_MUCL30387 | cds-NP_013522.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:943734-944915:- | gene-YLR418C_MUCL30388 | rna-NM_001182306.1_MUCL30388 | cds-NP_013522.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:937281-938462:- | gene-YLR418C_MUCL39482 | rna-NM_001182306.1_MUCL39482 | cds-NP_013522.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:931937-933118:- | gene-YLR418C_MUCL42920 | rna-NM_001182306.1_MUCL42920 | cds-NP_013522.1_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:956888-958069:- | gene-YLR418C_NCIM3186 | rna-NM_001182306.1_NCIM3186 | cds-NP_013522.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:946461-947642:- | gene-YLR418C_NCYC1407 | rna-NM_001182306.1_NCYC1407 | cds-NP_013522.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:932839-934020:- | gene-YLR418C_PE2H3 | rna-NM_001182306.1_PE2H3 | cds-NP_013522.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:932583-933764:- | gene-YLR418C_PE2H4 | rna-NM_001182306.1_PE2H4 | cds-NP_013522.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:956914-958095:- | gene-YLR418C_S288C | rna-NM_001182306.1_S288C | cds-NP_013522.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:96578-97759:+ | gene-YLR418C_SA1 | rna-NM_001182306.1_SA1 | cds-NP_013522.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:925400-926581:- | gene-YLR418C_ThermosaccDry | rna-NM_001182306.1_ThermosaccDry | cds-NP_013522.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:937929-939110:- | gene-YLR418C_VR1 | rna-NM_001182306.1_VR1 | cds-NP_013522.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:262115-263296:- | gene-YLR418C_ZTW1 | rna-NM_001182306.1_ZTW1 | cds-NP_013522.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:910971-912161:- | gene-YLR418C_Sparadoxus | rna-NM_001182306.1_Sparadoxus | cds-NP_013522.1_Sparadoxus | 89.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |