Gene name: CDC5
Reference locus (S288C): YMR001C
Gene biotype: protein_coding
Description: Cell cycle serine/threonine-protein kinase CDC5/MSD2; Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily
Top 10 interactors (score): MAD3 (0.999); MIH1 (0.999); BUB1 (0.999); MCD1 (0.999); SMC3 (0.998); CLB2 (0.998); IRR1 (0.998); IPL1 (0.998); ASE1 (0.998); BFA1 (0.998); CDH1 (0.998); SWE1 (0.998); CDC14 (0.998); KIP1 (0.997); CIN8 (0.997); CDC20 (0.997); NDC80 (0.996); ESP1 (0.996); BUB2 (0.995); DBF4 (0.995)
Homologues (species, bitscore): PLK1 (Homo sapiens, 325.1); Plk1 (Mus musculus, 330.1); plk1 (Danio rerio, 342.4); plk2 (Xenopus tropicalis, 326.6); polo (Drosophila melanogaster, 317.8); plk-1 (Caenorhabditis elegans, 322.8); CIPK9 (Arabidopsis thaliana, 179.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:318636-320753:- | gene-YMR001C_AKU4011 | rna-NM_001182497.1_AKU4011 | cds-NP_013714.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:222127-224244:+ | gene-YMR001C_BG1 | rna-NM_001182497.1_BG1 | cds-NP_013714.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:258570-260687:- | gene-YMR001C_Bruggeman | rna-NM_001182497.1_Bruggeman | cds-NP_013714.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:261062-263179:- | gene-YMR001C_CAT1 | rna-NM_001182497.1_CAT1 | cds-NP_013714.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:251577-253694:- | gene-YMR001C_CBS1585 | rna-NM_001182497.1_CBS1585 | cds-NP_013714.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:257107-259224:- | gene-YMR001C_CBS436 | rna-NM_001182497.1_CBS436 | cds-NP_013714.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:364981-367098:- | gene-YMR001C_CBS6412 | rna-NM_001182497.1_CBS6412 | cds-NP_013714.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:250833-252950:- | gene-YMR001C_CBS6413 | rna-NM_001182497.1_CBS6413 | cds-NP_013714.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:263750-265867:- | gene-YMR001C_CENPK1137D | rna-NM_001182497.1_CENPK1137D | cds-NP_013714.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:251384-253501:- | gene-YMR001C_EthanolRed | rna-NM_001182497.1_EthanolRed | cds-NP_013714.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:254570-256687:- | gene-YMR001C_FaliES1 | rna-NM_001182497.1_FaliES1 | cds-NP_013714.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000033.1:180260-182377:+ | gene-YMR001C_JAY291 | rna-NM_001182497.1_JAY291 | cds-NP_013714.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:256298-258415:- | gene-YMR001C_MUCL30387 | rna-NM_001182497.1_MUCL30387 | cds-NP_013714.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:260960-263077:- | gene-YMR001C_MUCL30388 | rna-NM_001182497.1_MUCL30388 | cds-NP_013714.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:251862-253979:- | gene-YMR001C_MUCL39482 | rna-NM_001182497.1_MUCL39482 | cds-NP_013714.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:257414-259531:- | gene-YMR001C_MUCL42920 | rna-NM_001182497.1_MUCL42920 | cds-NP_013714.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:268973-271090:- | gene-YMR001C_NCIM3186 | rna-NM_001182497.1_NCIM3186 | cds-NP_013714.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:251779-253896:- | gene-YMR001C_NCYC1407 | rna-NM_001182497.1_NCYC1407 | cds-NP_013714.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:257696-259813:- | gene-YMR001C_PE2H3 | rna-NM_001182497.1_PE2H3 | cds-NP_013714.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:263791-265908:- | gene-YMR001C_PE2H4 | rna-NM_001182497.1_PE2H4 | cds-NP_013714.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:269019-271136:- | gene-YMR001C_S288C | rna-NM_001182497.1_S288C | cds-NP_013714.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000005.1:267147-269264:+ | gene-YMR001C_SA1 | rna-NM_001182497.1_SA1 | cds-NP_013714.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:251635-253752:- | gene-YMR001C_ThermosaccDry | rna-NM_001182497.1_ThermosaccDry | cds-NP_013714.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:255583-257700:- | gene-YMR001C_VR1 | rna-NM_001182497.1_VR1 | cds-NP_013714.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:230687-232804:- | gene-YMR001C_ZTW1 | rna-NM_001182497.1_ZTW1 | cds-NP_013714.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:263156-265273:- | gene-YMR001C_Sparadoxus | rna-NM_001182497.1_Sparadoxus | cds-NP_013714.1_Sparadoxus | 93.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |