Gene name: CDC48
Reference locus (S288C): YDL126C
Gene biotype: protein_coding
Description: Transitional endoplasmic reticulum atpase; Cell division control protein 48; AAA ATPase; subunit of polyUb-selective segregase complex involved in ERAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, ribosome-associated degradation, ribophagy, homotypic ER membrane fusion, SCF complex disassembly, cell wall integrity during heat stress, and telomerase regulation; mobilizes membrane-anchored transcription factors by regulated Ub/proteasome-dependent processing (RUP); human ortholog VCP complements a cdc48 mutant
Top 10 interactors (score): UFD2 (0.999); UBX5 (0.999); DER1 (0.999); UFD1 (0.999); RPN11 (0.999); OTU1 (0.999); UBX2 (0.999); NPL4 (0.999); YOS9 (0.999); UBX4 (0.999); HRD1 (0.999); SSM4 (0.999); USA1 (0.999); HRD3 (0.999); DOA1 (0.999); RQC2 (0.999); VMS1 (0.999); RPN1 (0.999); SHP1 (0.999); UBX3 (0.999)
Homologues (species, bitscore): VCP (Homo sapiens, 1179.5); Vcp (Mus musculus, 1179.5); vcp (Danio rerio, 1184.5); vcp (Xenopus tropicalis, 1140.2); TER94 (Drosophila melanogaster, 1154.0); cdc-48.1 (Caenorhabditis elegans, 1153.7); AtCDC48C (Arabidopsis thaliana, 1152.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:220773-223280:- | gene-YDL126C_AKU4011 | rna-NM_001180185.1_AKU4011 | cds-NP_010157.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:326701-329208:+ | gene-YDL126C_BG1 | rna-NM_001180185.1_BG1 | cds-NP_010157.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:237926-240433:- | gene-YDL126C_Bruggeman | rna-NM_001180185.1_Bruggeman | cds-NP_010157.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:234928-237435:- | gene-YDL126C_CAT1 | rna-NM_001180185.1_CAT1 | cds-NP_010157.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:219038-221545:- | gene-YDL126C_CBS1585 | rna-NM_001180185.1_CBS1585 | cds-NP_010157.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:235691-238198:- | gene-YDL126C_CBS436 | rna-NM_001180185.1_CBS436 | cds-NP_010157.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:217463-219970:- | gene-YDL126C_CBS6412 | rna-NM_001180185.1_CBS6412 | cds-NP_010157.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:237198-239705:- | gene-YDL126C_CBS6413 | rna-NM_001180185.1_CBS6413 | cds-NP_010157.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:234929-237436:- | gene-YDL126C_CENPK1137D | rna-NM_001180185.1_CENPK1137D | cds-NP_010157.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:231803-234310:- | gene-YDL126C_EthanolRed | rna-NM_001180185.1_EthanolRed | cds-NP_010157.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:237773-240280:- | gene-YDL126C_FaliES1 | rna-NM_001180185.1_FaliES1 | cds-NP_010157.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:7816-10323:- | gene-YDL126C_JAY291 | rna-NM_001180185.1_JAY291 | cds-NP_010157.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:235981-238488:- | gene-YDL126C_MUCL30387 | rna-NM_001180185.1_MUCL30387 | cds-NP_010157.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:226743-229250:- | gene-YDL126C_MUCL30388 | rna-NM_001180185.1_MUCL30388 | cds-NP_010157.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:220140-222647:- | gene-YDL126C_MUCL39482 | rna-NM_001180185.1_MUCL39482 | cds-NP_010157.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:141938-144445:- | gene-YDL126C_MUCL42920 | rna-NM_001180185.1_MUCL42920 | cds-NP_010157.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:236080-238587:- | gene-YDL126C_NCIM3186 | rna-NM_001180185.1_NCIM3186 | cds-NP_010157.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:220171-222678:- | gene-YDL126C_NCYC1407 | rna-NM_001180185.1_NCYC1407 | cds-NP_010157.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:226917-229424:- | gene-YDL126C_PE2H3 | rna-NM_001180185.1_PE2H3 | cds-NP_010157.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:226921-229428:- | gene-YDL126C_PE2H4 | rna-NM_001180185.1_PE2H4 | cds-NP_010157.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:236157-238664:- | gene-YDL126C_S288C | rna-NM_001180185.1_S288C | cds-NP_010157.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:196261-198768:+ | gene-YDL126C_SA1 | rna-NM_001180185.1_SA1 | cds-NP_010157.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:237284-239791:- | gene-YDL126C_ThermosaccDry | rna-NM_001180185.1_ThermosaccDry | cds-NP_010157.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:239391-241898:- | gene-YDL126C_VR1 | rna-NM_001180185.1_VR1 | cds-NP_010157.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:235214-237721:- | gene-YDL126C_ZTW1 | rna-NM_001180185.1_ZTW1 | cds-NP_010157.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:237347-239854:- | gene-YDL126C_Sparadoxus | rna-NM_001180185.1_Sparadoxus | cds-NP_010157.1_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |