Gene name: CDC45
Reference locus (S288C): YLR103C
Gene biotype: protein_coding
Description: Cell division control protein 45; DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
Top 10 interactors (score): CSM3 (0.999); DBF4 (0.999); PSF2 (0.999); DPB2 (0.999); PRI2 (0.999); DPB11 (0.999); TOF1 (0.999); PSF1 (0.999); MCM5 (0.999); PSF3 (0.999); CHK1 (0.999); SLD3 (0.999); SLD5 (0.999); CTF4 (0.999); ORC1 (0.999); MCM10 (0.999); POL12 (0.999); MCM4 (0.999); MRC1 (0.999); POL2 (0.999)
Homologues (species, bitscore): CDC45 (Homo sapiens, 159.5); Cdc45 (Mus musculus, 154.8); cdc45 (Danio rerio, 173.7); cdc45 (Xenopus tropicalis, 180.3); CDC45L (Drosophila melanogaster, 186.4); F34D10.2 (Caenorhabditis elegans, 78.6); CDC45 (Arabidopsis thaliana, 173.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:326489-328444:- | gene-YLR103C_AKU4011 | rna-NM_001181990.1_AKU4011 | cds-NP_013204.1_AKU4011 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:289669-291621:- | gene-YLR103C_BG1 | rna-NM_001181990.1_BG1 | cds-NP_013204.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:336338-338293:- | gene-YLR103C_Bruggeman | rna-NM_001181990.1_Bruggeman | cds-NP_013204.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:336690-338642:- | gene-YLR103C_CAT1 | rna-NM_001181990.1_CAT1 | cds-NP_013204.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:333631-335586:- | gene-YLR103C_CBS1585 | rna-NM_001181990.1_CBS1585 | cds-NP_013204.1_CBS1585 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:324198-326150:- | gene-YLR103C_CBS436 | rna-NM_001181990.1_CBS436 | cds-NP_013204.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:332050-334005:- | gene-YLR103C_CBS6412 | rna-NM_001181990.1_CBS6412 | cds-NP_013204.1_CBS6412 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:333897-335852:- | gene-YLR103C_CBS6413 | rna-NM_001181990.1_CBS6413 | cds-NP_013204.1_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:329013-330965:- | gene-YLR103C_CENPK1137D | rna-NM_001181990.1_CENPK1137D | cds-NP_013204.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:326048-328003:- | gene-YLR103C_EthanolRed | rna-NM_001181990.1_EthanolRed | cds-NP_013204.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:325867-327822:- | gene-YLR103C_FaliES1 | rna-NM_001181990.1_FaliES1 | cds-NP_013204.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000129.1:100798-102750:- | gene-YLR103C_JAY291 | rna-NM_001181990.1_JAY291 | cds-NP_013204.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:333718-335670:- | gene-YLR103C_MUCL30387 | rna-NM_001181990.1_MUCL30387 | cds-NP_013204.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:341382-343337:- | gene-YLR103C_MUCL30388 | rna-NM_001181990.1_MUCL30388 | cds-NP_013204.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:334139-336094:- | gene-YLR103C_MUCL39482 | rna-NM_001181990.1_MUCL39482 | cds-NP_013204.1_MUCL39482 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:334043-335998:- | gene-YLR103C_MUCL42920 | rna-NM_001181990.1_MUCL42920 | cds-NP_013204.1_MUCL42920 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:343963-345915:- | gene-YLR103C_NCIM3186 | rna-NM_001181990.1_NCIM3186 | cds-NP_013204.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:326202-328157:- | gene-YLR103C_NCYC1407 | rna-NM_001181990.1_NCYC1407 | cds-NP_013204.1_NCYC1407 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:331963-333915:- | gene-YLR103C_PE2H3 | rna-NM_001181990.1_PE2H3 | cds-NP_013204.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:331704-333656:- | gene-YLR103C_PE2H4 | rna-NM_001181990.1_PE2H4 | cds-NP_013204.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:343989-345941:- | gene-YLR103C_S288C | rna-NM_001181990.1_S288C | cds-NP_013204.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000033.1:28153-30108:+ | gene-YLR103C_SA1 | rna-NM_001181990.1_SA1 | cds-NP_013204.1_SA1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:326040-327995:- | gene-YLR103C_ThermosaccDry | rna-NM_001181990.1_ThermosaccDry | cds-NP_013204.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:340204-342156:- | gene-YLR103C_VR1 | rna-NM_001181990.1_VR1 | cds-NP_013204.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:325464-327419:- | gene-YLR103C_ZTW1 | rna-NM_001181990.1_ZTW1 | cds-NP_013204.1_ZTW1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:334242-336200:- | gene-YLR103C_Sparadoxus | rna-NM_001181990.1_Sparadoxus | cds-NP_013204.1_Sparadoxus | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |