Gene name: CDC4
Reference locus (S288C): YFL009W
Gene biotype: protein_coding
Description: Cell division control protein 4; F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p
Top 10 interactors (score): CDC6 (0.999); CDC34 (0.999); SIC1 (0.999); SKP1 (0.999); CDC53 (0.999); HRT1 (0.999); GRR1 (0.98); FAR1 (0.966); CDC23 (0.958); MET30 (0.95); CDC16 (0.938); CDC27 (0.936); CDC28 (0.935); APC1 (0.931); APC11 (0.926); DOC1 (0.925); CLN2 (0.911); SLX5 (0.911); ASI3 (0.907); SLX8 (0.907)
Homologues (species, bitscore): FBXW7 (Homo sapiens, 229.2); Fbxw7 (Mus musculus, 228.8); FBXW7 (Danio rerio, 236.1); fbxw7 (Xenopus tropicalis, 226.5); ago (Drosophila melanogaster, 246.1); sel-10 (Caenorhabditis elegans, 224.9); TOZ (Arabidopsis thaliana, 92.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:112552-114897:+ | gene-YFL009W_AKU4011 | rna-NM_001179957.1_AKU4011 | cds-NP_116585.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000019.1:1-1356:- | gene-YFL009W_BG1 | rna-NM_001179957.1_BG1 | cds-NP_116585.1_BG1 | 57.8 | 57.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:111877-114465:+ | gene-YFL009W_Bruggeman | rna-NM_001179957.1_Bruggeman | cds-NP_116585.1_Bruggeman | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:117863-120446:+ | gene-YFL009W_CAT1 | rna-NM_001179957.1_CAT1 | cds-NP_116585.1_CAT1 | 90.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:113377-115722:+ | gene-YFL009W_CBS1585 | rna-NM_001179957.1_CBS1585 | cds-NP_116585.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:87556-90393:+ | gene-YFL009W_CBS436 | rna-NM_001179957.1_CBS436 | cds-NP_116585.1_CBS436 | 82.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:113118-115463:+ | gene-YFL009W_CBS6412 | rna-NM_001179957.1_CBS6412 | cds-NP_116585.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:115629-117974:+ | gene-YFL009W_CBS6413 | rna-NM_001179957.1_CBS6413 | cds-NP_116585.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:112435-114774:+ | gene-YFL009W_CENPK1137D | rna-NM_001179957.1_CENPK1137D | cds-NP_116585.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:111546-113885:+ | gene-YFL009W_EthanolRed | rna-NM_001179957.1_EthanolRed | cds-NP_116585.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:113193-115532:+ | gene-YFL009W_FaliES1 | rna-NM_001179957.1_FaliES1 | cds-NP_116585.1_FaliES1 | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000449.1:14697-16382:+ | gene-YFL009W_JAY291 | rna-NM_001179957.1_JAY291 | cds-NP_116585.1_JAY291 | 71.9 | 72.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:113508-116096:+ | gene-YFL009W_MUCL30387 | rna-NM_001179957.1_MUCL30387 | cds-NP_116585.1_MUCL30387 | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:111478-114066:+ | gene-YFL009W_MUCL30388 | rna-NM_001179957.1_MUCL30388 | cds-NP_116585.1_MUCL30388 | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:111821-114166:+ | gene-YFL009W_MUCL39482 | rna-NM_001179957.1_MUCL39482 | cds-NP_116585.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:111091-113430:+ | gene-YFL009W_MUCL42920 | rna-NM_001179957.1_MUCL42920 | cds-NP_116585.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:116144-118483:+ | gene-YFL009W_NCIM3186 | rna-NM_001179957.1_NCIM3186 | cds-NP_116585.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:112843-115182:+ | gene-YFL009W_NCYC1407 | rna-NM_001179957.1_NCYC1407 | cds-NP_116585.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:132730-135069:+ | gene-YFL009W_PE2H3 | rna-NM_001179957.1_PE2H3 | cds-NP_116585.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:132278-134617:+ | gene-YFL009W_PE2H4 | rna-NM_001179957.1_PE2H4 | cds-NP_116585.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:116145-118484:+ | gene-YFL009W_S288C | rna-NM_001179957.1_S288C | cds-NP_116585.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000105.1:28902-30336:+ | gene-YFL009W_SA1 | rna-NM_001179957.1_SA1 | cds-NP_116585.1_SA1 | 61.0 | 61.3 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:112353-114692:+ | gene-YFL009W_ThermosaccDry | rna-NM_001179957.1_ThermosaccDry | cds-NP_116585.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:121995-124578:+ | gene-YFL009W_VR1 | rna-NM_001179957.1_VR1 | cds-NP_116585.1_VR1 | 90.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:42795-45140:+ | gene-YFL009W_ZTW1 | rna-NM_001179957.1_ZTW1 | cds-NP_116585.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:136922-139255:+ | gene-YFL009W_Sparadoxus | rna-NM_001179957.1_Sparadoxus | cds-NP_116585.1_Sparadoxus | 90.1 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |