Gene name: CDC34
Reference locus (S288C): YDR054C
Gene biotype: protein_coding
Description: Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant
Top 10 interactors (score): SKP1 (0.999); CDC4 (0.999); HRT1 (0.999); CDC53 (0.999); UBA1 (0.999); UBI4 (0.994); RUB1 (0.971); RSP5 (0.968); MET30 (0.966); SIC1 (0.939); ULA1 (0.921); GRR1 (0.919); MMS2 (0.919); UBA3 (0.918); YOS9 (0.911); RPN7 (0.911); RTT101 (0.91); TIF11 (0.892); SMT3 (0.889); VMS1 (0.886)
Homologues (species, bitscore): UBE2R2 (Homo sapiens, 151.0); Ube2r2 (Mus musculus, 151.0); cdc34b (Danio rerio, 150.2); ube2r2 (Xenopus tropicalis, 150.2); CG7656 (Drosophila melanogaster, 150.6); ubc-3 (Caenorhabditis elegans, 153.7); UBC7 (Arabidopsis thaliana, 154.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:538985-539872:- | gene-YDR054C_AKU4011 | rna-NM_001180362.1_AKU4011 | cds-NP_010339.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:15344-16231:+ | gene-YDR054C_BG1 | rna-NM_001180362.1_BG1 | cds-NP_010339.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:571323-572210:- | gene-YDR054C_Bruggeman | rna-NM_001180362.1_Bruggeman | cds-NP_010339.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:554323-555210:- | gene-YDR054C_CAT1 | rna-NM_001180362.1_CAT1 | cds-NP_010339.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:529939-530826:- | gene-YDR054C_CBS1585 | rna-NM_001180362.1_CBS1585 | cds-NP_010339.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:555103-555990:- | gene-YDR054C_CBS436 | rna-NM_001180362.1_CBS436 | cds-NP_010339.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:526351-527238:- | gene-YDR054C_CBS6412 | rna-NM_001180362.1_CBS6412 | cds-NP_010339.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:555020-555907:- | gene-YDR054C_CBS6413 | rna-NM_001180362.1_CBS6413 | cds-NP_010339.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:560411-561298:- | gene-YDR054C_CENPK1137D | rna-NM_001180362.1_CENPK1137D | cds-NP_010339.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:540810-541697:- | gene-YDR054C_EthanolRed | rna-NM_001180362.1_EthanolRed | cds-NP_010339.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:547250-548137:- | gene-YDR054C_FaliES1 | rna-NM_001180362.1_FaliES1 | cds-NP_010339.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000246.1:6580-7467:+ | gene-YDR054C_JAY291 | rna-NM_001180362.1_JAY291 | cds-NP_010339.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:555985-556872:- | gene-YDR054C_MUCL30387 | rna-NM_001180362.1_MUCL30387 | cds-NP_010339.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:546404-547291:- | gene-YDR054C_MUCL30388 | rna-NM_001180362.1_MUCL30388 | cds-NP_010339.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:531310-532197:- | gene-YDR054C_MUCL39482 | rna-NM_001180362.1_MUCL39482 | cds-NP_010339.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:461785-462672:- | gene-YDR054C_MUCL42920 | rna-NM_001180362.1_MUCL42920 | cds-NP_010339.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:561363-562250:- | gene-YDR054C_NCIM3186 | rna-NM_001180362.1_NCIM3186 | cds-NP_010339.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:530245-531132:- | gene-YDR054C_NCYC1407 | rna-NM_001180362.1_NCYC1407 | cds-NP_010339.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:549879-550766:- | gene-YDR054C_PE2H3 | rna-NM_001180362.1_PE2H3 | cds-NP_010339.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:549184-550071:- | gene-YDR054C_PE2H4 | rna-NM_001180362.1_PE2H4 | cds-NP_010339.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:561440-562327:- | gene-YDR054C_S288C | rna-NM_001180362.1_S288C | cds-NP_010339.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:83163-84050:+ | gene-YDR054C_SA1 | rna-NM_001180362.1_SA1 | cds-NP_010339.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:546990-547877:- | gene-YDR054C_ThermosaccDry | rna-NM_001180362.1_ThermosaccDry | cds-NP_010339.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:559693-560580:- | gene-YDR054C_VR1 | rna-NM_001180362.1_VR1 | cds-NP_010339.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:544594-545481:- | gene-YDR054C_ZTW1 | rna-NM_001180362.1_ZTW1 | cds-NP_010339.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:548988-549881:- | gene-YDR054C_Sparadoxus | rna-NM_001180362.1_Sparadoxus | cds-NP_010339.1_Sparadoxus | 94.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |