Gene name: CDC28
Reference locus (S288C): YBR160W
Gene biotype: protein_coding
Description: Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
Top 10 interactors (score): CDC14 (0.999); MIH1 (0.999); CLB4 (0.999); CLB3 (0.999); CLN2 (0.999); CLB1 (0.999); CLB2 (0.999); SWE1 (0.999); CLB5 (0.999); CDC6 (0.999); CLN3 (0.999); CLN1 (0.999); CLB6 (0.999); CKS1 (0.999); ORC2 (0.998); FAR1 (0.998); SIC1 (0.998); POL30 (0.997); ESP1 (0.997); SWI6 (0.997)
Homologues (species, bitscore): TEN1-CDK3 (Homo sapiens, 392.1); Cdk1 (Mus musculus, 373.2); cdk2 (Danio rerio, 388.3); cdk2 (Xenopus tropicalis, 361.3); Cdk1 (Drosophila melanogaster, 369.4); cdk-1 (Caenorhabditis elegans, 345.9); CDC2 (Arabidopsis thaliana, 379.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:542961-543857:+ | gene-YBR160W_AKU4011 | rna-NM_001178508.3_AKU4011 | cds-NP_009718.3_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:533523-534419:+ | gene-YBR160W_BG1 | rna-NM_001178508.3_BG1 | cds-NP_009718.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:546003-546899:+ | gene-YBR160W_Bruggeman | rna-NM_001178508.3_Bruggeman | cds-NP_009718.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:440103-440999:+ | gene-YBR160W_CAT1 | rna-NM_001178508.3_CAT1 | cds-NP_009718.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:534740-535636:+ | gene-YBR160W_CBS1585 | rna-NM_001178508.3_CBS1585 | cds-NP_009718.3_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:542839-543735:+ | gene-YBR160W_CBS436 | rna-NM_001178508.3_CBS436 | cds-NP_009718.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:632221-633117:+ | gene-YBR160W_CBS6412 | rna-NM_001178508.3_CBS6412 | cds-NP_009718.3_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:540375-541271:+ | gene-YBR160W_CBS6413 | rna-NM_001178508.3_CBS6413 | cds-NP_009718.3_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:553854-554750:+ | gene-YBR160W_CENPK1137D | rna-NM_001178508.3_CENPK1137D | cds-NP_009718.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:668797-669693:+ | gene-YBR160W_EthanolRed | rna-NM_001178508.3_EthanolRed | cds-NP_009718.3_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:559041-559937:+ | gene-YBR160W_FaliES1 | rna-NM_001178508.3_FaliES1 | cds-NP_009718.3_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000322.1:274-1170:- | gene-YBR160W_JAY291 | rna-NM_001178508.3_JAY291 | cds-NP_009718.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:547630-548526:+ | gene-YBR160W_MUCL30387 | rna-NM_001178508.3_MUCL30387 | cds-NP_009718.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:546924-547820:+ | gene-YBR160W_MUCL30388 | rna-NM_001178508.3_MUCL30388 | cds-NP_009718.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:533127-534023:+ | gene-YBR160W_MUCL39482 | rna-NM_001178508.3_MUCL39482 | cds-NP_009718.3_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:543024-543920:+ | gene-YBR160W_MUCL42920 | rna-NM_001178508.3_MUCL42920 | cds-NP_009718.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:559875-560771:+ | gene-YBR160W_NCIM3186 | rna-NM_001178508.3_NCIM3186 | cds-NP_009718.3_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:535677-536573:+ | gene-YBR160W_NCYC1407 | rna-NM_001178508.3_NCYC1407 | cds-NP_009718.3_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:548312-549208:+ | gene-YBR160W_PE2H3 | rna-NM_001178508.3_PE2H3 | cds-NP_009718.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:545988-546884:+ | gene-YBR160W_PE2H4 | rna-NM_001178508.3_PE2H4 | cds-NP_009718.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:560078-560974:+ | gene-YBR160W_S288C | rna-NM_001178508.3_S288C | cds-NP_009718.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:81252-82148:+ | gene-YBR160W_SA1 | rna-NM_001178508.3_SA1 | cds-NP_009718.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:558034-558930:+ | gene-YBR160W_ThermosaccDry | rna-NM_001178508.3_ThermosaccDry | cds-NP_009718.3_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:539498-540394:+ | gene-YBR160W_VR1 | rna-NM_001178508.3_VR1 | cds-NP_009718.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:533154-534050:+ | gene-YBR160W_ZTW1 | rna-NM_001178508.3_ZTW1 | cds-NP_009718.3_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:570395-571291:+ | gene-YBR160W_Sparadoxus | rna-NM_001178508.3_Sparadoxus | cds-NP_009718.3_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |