Gene name: CDC25
Reference locus (S288C): YLR310C
Gene biotype: protein_coding
Description: Cell division control protein 25; Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain
Top 10 interactors (score): RAS2 (0.999); RAS1 (0.999); CDC42 (0.993); CYR1 (0.985); IRA1 (0.983); RHO1 (0.976); RSR1 (0.973); BMH1 (0.969); IRA2 (0.966); TPK1 (0.962); RHO2 (0.946); RHO3 (0.944); RHO5 (0.944); RHO4 (0.944); GEM1 (0.935); TEP1 (0.91); GPA2 (0.9); STE7 (0.895); STE4 (0.895); TFS1 (0.891)
Homologues (species, bitscore): SOS1 (Homo sapiens, 167.5); Sos1 (Mus musculus, 170.2); sos2 (Danio rerio, 157.5); sos1 (Xenopus tropicalis, 165.6); Sos (Drosophila melanogaster, 150.2); Y34B4A.4 (Caenorhabditis elegans, 136.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:700674-705443:- | gene-YLR310C_AKU4011 | rna-NM_001182198.1_AKU4011 | cds-NP_013413.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:27184-31953:+ | gene-YLR310C_BG1 | rna-NM_001182198.1_BG1 | cds-NP_013413.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:736501-741270:- | gene-YLR310C_Bruggeman | rna-NM_001182198.1_Bruggeman | cds-NP_013413.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:734673-739442:- | gene-YLR310C_CAT1 | rna-NM_001182198.1_CAT1 | cds-NP_013413.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:735601-740370:- | gene-YLR310C_CBS1585 | rna-NM_001182198.1_CBS1585 | cds-NP_013413.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:720214-724983:- | gene-YLR310C_CBS436 | rna-NM_001182198.1_CBS436 | cds-NP_013413.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:698240-703009:- | gene-YLR310C_CBS6412 | rna-NM_001182198.1_CBS6412 | cds-NP_013413.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:736264-741033:- | gene-YLR310C_CBS6413 | rna-NM_001182198.1_CBS6413 | cds-NP_013413.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:736837-741606:- | gene-YLR310C_CENPK1137D | rna-NM_001182198.1_CENPK1137D | cds-NP_013413.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:693954-698723:- | gene-YLR310C_EthanolRed | rna-NM_001182198.1_EthanolRed | cds-NP_013413.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:723154-727923:- | gene-YLR310C_FaliES1 | rna-NM_001182198.1_FaliES1 | cds-NP_013413.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000296.1:39902-44671:+ | gene-YLR310C_JAY291 | rna-NM_001182198.1_JAY291 | cds-NP_013413.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:735737-740506:- | gene-YLR310C_MUCL30387 | rna-NM_001182198.1_MUCL30387 | cds-NP_013413.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:741320-746089:- | gene-YLR310C_MUCL30388 | rna-NM_001182198.1_MUCL30388 | cds-NP_013413.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:736831-741600:- | gene-YLR310C_MUCL39482 | rna-NM_001182198.1_MUCL39482 | cds-NP_013413.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:731986-736755:- | gene-YLR310C_MUCL42920 | rna-NM_001182198.1_MUCL42920 | cds-NP_013413.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:752198-756967:- | gene-YLR310C_NCIM3186 | rna-NM_001182198.1_NCIM3186 | cds-NP_013413.1_NCIM3186 | 94.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:746173-750942:- | gene-YLR310C_NCYC1407 | rna-NM_001182198.1_NCYC1407 | cds-NP_013413.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:733982-738751:- | gene-YLR310C_PE2H3 | rna-NM_001182198.1_PE2H3 | cds-NP_013413.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:733726-738495:- | gene-YLR310C_PE2H4 | rna-NM_001182198.1_PE2H4 | cds-NP_013413.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:752224-756993:- | gene-YLR310C_S288C | rna-NM_001182198.1_S288C | cds-NP_013413.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000039.1:27310-32079:+ | gene-YLR310C_SA1 | rna-NM_001182198.1_SA1 | cds-NP_013413.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:725048-729817:- | gene-YLR310C_ThermosaccDry | rna-NM_001182198.1_ThermosaccDry | cds-NP_013413.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:737191-741960:- | gene-YLR310C_VR1 | rna-NM_001182198.1_VR1 | cds-NP_013413.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:63472-68241:- | gene-YLR310C_ZTW1 | rna-NM_001182198.1_ZTW1 | cds-NP_013413.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:711242-716008:- | gene-YLR310C_Sparadoxus | rna-NM_001182198.1_Sparadoxus | cds-NP_013413.1_Sparadoxus | 90.2 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |