Gene name: CDC19
Reference locus (S288C): YAL038W
Gene biotype: protein_coding
Description: Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication
Top 10 interactors (score): PDC1 (0.999); ENO2 (0.999); FBA1 (0.999); PGI1 (0.999); GPM1 (0.999); ENO1 (0.999); PGK1 (0.998); PYC2 (0.997); TPI1 (0.997); PCK1 (0.995); TDH2 (0.995); PYC1 (0.994); TDH3 (0.994); ERR2 (0.993); ERR3 (0.993); MAE1 (0.992); PFK1 (0.99); PDC5 (0.988); ADH1 (0.987); PDB1 (0.986)
Homologues (species, bitscore): PKLR (Homo sapiens, 491.5); Pkm (Mus musculus, 496.5); pkmb (Danio rerio, 481.5); pkm (Xenopus tropicalis, 493.4); PyK (Drosophila melanogaster, 487.6); pyk-1 (Caenorhabditis elegans, 471.9); AT5G63680 (Arabidopsis thaliana, 372.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005295.1:56916-58418:+ | gene-YAL038W_AKU4011 | rna-NM_001178183.1_AKU4011 | cds-NP_009362.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000070.1:44043-45545:+ | gene-YAL038W_BG1 | rna-NM_001178183.1_BG1 | cds-NP_009362.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005503.1:71345-72847:+ | gene-YAL038W_Bruggeman | rna-NM_001178183.1_Bruggeman | cds-NP_009362.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005519.1:58136-59638:+ | gene-YAL038W_CAT1 | rna-NM_001178183.1_CAT1 | cds-NP_009362.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005359.1:69935-71437:+ | gene-YAL038W_CBS1585 | rna-NM_001178183.1_CBS1585 | cds-NP_009362.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005343.1:70180-71682:+ | gene-YAL038W_CBS436 | rna-NM_001178183.1_CBS436 | cds-NP_009362.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005327.1:56079-57581:+ | gene-YAL038W_CBS6412 | rna-NM_001178183.1_CBS6412 | cds-NP_009362.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005311.1:68198-69700:+ | gene-YAL038W_CBS6413 | rna-NM_001178183.1_CBS6413 | cds-NP_009362.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001522.1:71876-73378:+ | gene-YAL038W_CENPK1137D | rna-NM_001178183.1_CENPK1137D | cds-NP_009362.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005471.1:58327-59829:+ | gene-YAL038W_EthanolRed | rna-NM_001178183.1_EthanolRed | cds-NP_009362.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005535.1:72273-73775:+ | gene-YAL038W_FaliES1 | rna-NM_001178183.1_FaliES1 | cds-NP_009362.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000084.1:44228-45730:+ | gene-YAL038W_JAY291 | rna-NM_001178183.1_JAY291 | cds-NP_009362.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005407.1:72880-74382:+ | gene-YAL038W_MUCL30387 | rna-NM_001178183.1_MUCL30387 | cds-NP_009362.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005439.1:69429-70931:+ | gene-YAL038W_MUCL30388 | rna-NM_001178183.1_MUCL30388 | cds-NP_009362.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005279.1:68719-70221:+ | gene-YAL038W_MUCL39482 | rna-NM_001178183.1_MUCL39482 | cds-NP_009362.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005423.1:71088-72590:+ | gene-YAL038W_MUCL42920 | rna-NM_001178183.1_MUCL42920 | cds-NP_009362.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011810.1:71663-73165:+ | gene-YAL038W_NCIM3186 | rna-NM_001178183.1_NCIM3186 | cds-NP_009362.1_NCIM3186 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005263.1:56601-58103:+ | gene-YAL038W_NCYC1407 | rna-NM_001178183.1_NCYC1407 | cds-NP_009362.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994140.1:58498-60000:+ | gene-YAL038W_PE2H3 | rna-NM_001178183.1_PE2H3 | cds-NP_009362.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999872.1:58217-59719:+ | gene-YAL038W_PE2H4 | rna-NM_001178183.1_PE2H4 | cds-NP_009362.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001133.9:71786-73288:+ | gene-YAL038W_S288C | rna-NM_001178183.1_S288C | cds-NP_009362.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000059.1:906-2408:+ | gene-YAL038W_SA1 | rna-NM_001178183.1_SA1 | cds-NP_009362.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005487.1:72468-73970:+ | gene-YAL038W_ThermosaccDry | rna-NM_001178183.1_ThermosaccDry | cds-NP_009362.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005455.1:73752-75254:+ | gene-YAL038W_VR1 | rna-NM_001178183.1_VR1 | cds-NP_009362.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000002.1:44288-45790:+ | gene-YAL038W_ZTW1 | rna-NM_001178183.1_ZTW1 | cds-NP_009362.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047487.1:61890-63392:+ | gene-YAL038W_Sparadoxus | rna-NM_001178183.1_Sparadoxus | cds-NP_009362.1_Sparadoxus | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |