Gene name: CDC14
Reference locus (S288C): YFR028C
Gene biotype: protein_coding
Description: Tyrosine-protein phosphatase CDC14; Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of yeast cdc14-1 mutant
Top 10 interactors (score): NET1 (0.999); CDC28 (0.999); SIR2 (0.999); CDH1 (0.999); SIC1 (0.999); CDC5 (0.998); DBF2 (0.998); MIH1 (0.997); CDC15 (0.997); ESP1 (0.997); MOB1 (0.996); HOF1 (0.993); CBK1 (0.991); TEM1 (0.991); CDC20 (0.989); CLB2 (0.986); LTE1 (0.982); BUB2 (0.981); DBF20 (0.981); SWI5 (0.977)
Homologues (species, bitscore): CDC14A (Homo sapiens, 243.0); Cdc14a (Mus musculus, 253.4); cdc14aa (Danio rerio, 240.4); cdc14a (Xenopus tropicalis, 228.0); cdc14 (Drosophila melanogaster, 239.6); cdc-14 (Caenorhabditis elegans, 196.8); PTEN2A (Arabidopsis thaliana, 60.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:198616-200271:- | gene-YFR028C_AKU4011 | rna-NM_001179993.3_AKU4011 | cds-NP_116684.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000071.1:60808-62463:+ | gene-YFR028C_BG1 | rna-NM_001179993.3_BG1 | cds-NP_116684.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:202257-203912:- | gene-YFR028C_Bruggeman | rna-NM_001179993.3_Bruggeman | cds-NP_116684.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:204202-205857:- | gene-YFR028C_CAT1 | rna-NM_001179993.3_CAT1 | cds-NP_116684.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:200107-201762:- | gene-YFR028C_CBS1585 | rna-NM_001179993.3_CBS1585 | cds-NP_116684.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:173057-174712:- | gene-YFR028C_CBS436 | rna-NM_001179993.3_CBS436 | cds-NP_116684.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:199188-200843:- | gene-YFR028C_CBS6412 | rna-NM_001179993.3_CBS6412 | cds-NP_116684.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:201843-203498:- | gene-YFR028C_CBS6413 | rna-NM_001179993.3_CBS6413 | cds-NP_116684.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:204421-206076:- | gene-YFR028C_CENPK1137D | rna-NM_001179993.3_CENPK1137D | cds-NP_116684.3_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:197725-199380:- | gene-YFR028C_EthanolRed | rna-NM_001179993.3_EthanolRed | cds-NP_116684.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:199375-201030:- | gene-YFR028C_FaliES1 | rna-NM_001179993.3_FaliES1 | cds-NP_116684.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000453.1:2491-4146:- | gene-YFR028C_JAY291 | rna-NM_001179993.3_JAY291 | cds-NP_116684.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:202697-204352:- | gene-YFR028C_MUCL30387 | rna-NM_001179993.3_MUCL30387 | cds-NP_116684.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:198193-199848:- | gene-YFR028C_MUCL30388 | rna-NM_001179993.3_MUCL30388 | cds-NP_116684.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:198026-199681:- | gene-YFR028C_MUCL39482 | rna-NM_001179993.3_MUCL39482 | cds-NP_116684.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:197338-198993:- | gene-YFR028C_MUCL42920 | rna-NM_001179993.3_MUCL42920 | cds-NP_116684.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:208412-210067:- | gene-YFR028C_NCIM3186 | rna-NM_001179993.3_NCIM3186 | cds-NP_116684.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:198908-200563:- | gene-YFR028C_NCYC1407 | rna-NM_001179993.3_NCYC1407 | cds-NP_116684.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:240885-242540:- | gene-YFR028C_PE2H3 | rna-NM_001179993.3_PE2H3 | cds-NP_116684.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:240433-242088:- | gene-YFR028C_PE2H4 | rna-NM_001179993.3_PE2H4 | cds-NP_116684.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:208413-210068:- | gene-YFR028C_S288C | rna-NM_001179993.3_S288C | cds-NP_116684.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:114402-116057:+ | gene-YFR028C_SA1 | rna-NM_001179993.3_SA1 | cds-NP_116684.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:198532-200187:- | gene-YFR028C_ThermosaccDry | rna-NM_001179993.3_ThermosaccDry | cds-NP_116684.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:214272-215927:- | gene-YFR028C_VR1 | rna-NM_001179993.3_VR1 | cds-NP_116684.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:129003-130658:- | gene-YFR028C_ZTW1 | rna-NM_001179993.3_ZTW1 | cds-NP_116684.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:222152-223810:- | gene-YFR028C_Sparadoxus | rna-NM_001179993.3_Sparadoxus | cds-NP_116684.3_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |