Gene name: CDC123
Reference locus (S288C): YLR215C
Gene biotype: protein_coding
Description: Cell division cycle protein 123; Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant
Top 10 interactors (score): GCD11 (0.997); DMA2 (0.928); DMA1 (0.92); TRM732 (0.822); SUI2 (0.795); SFP1 (0.743); ATS1 (0.738); UBC13 (0.69); RAI1 (0.684); YIR035C (0.574); SPE1 (0.546); UBP15 (0.534); YJR112W-A (0.499); IST3 (0.497); SUI3 (0.493); TIF4631 (0.487); POB3 (0.473); TIF1 (0.469); ARL3 (0.461); SRM1 (0.445)
Homologues (species, bitscore): CDC123 (Homo sapiens, 179.5); Cdc123 (Mus musculus, 185.3); cdc123 (Danio rerio, 183.3); cdc123 (Xenopus tropicalis, 188.0); EDA35 (Arabidopsis thaliana, 144.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:524919-526001:- | gene-YLR215C_AKU4011 | rna-NM_001182102.1_AKU4011 | cds-NP_013316.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000177.1:82177-83259:- | gene-YLR215C_BG1 | rna-NM_001182102.1_BG1 | cds-NP_013316.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:565146-566228:- | gene-YLR215C_Bruggeman | rna-NM_001182102.1_Bruggeman | cds-NP_013316.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:564795-565877:- | gene-YLR215C_CAT1 | rna-NM_001182102.1_CAT1 | cds-NP_013316.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:560411-561493:- | gene-YLR215C_CBS1585 | rna-NM_001182102.1_CBS1585 | cds-NP_013316.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:550613-551695:- | gene-YLR215C_CBS436 | rna-NM_001182102.1_CBS436 | cds-NP_013316.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:528973-530055:- | gene-YLR215C_CBS6412 | rna-NM_001182102.1_CBS6412 | cds-NP_013316.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:560708-561790:- | gene-YLR215C_CBS6413 | rna-NM_001182102.1_CBS6413 | cds-NP_013316.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:555416-556498:- | gene-YLR215C_CENPK1137D | rna-NM_001182102.1_CENPK1137D | cds-NP_013316.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:524431-525513:- | gene-YLR215C_EthanolRed | rna-NM_001182102.1_EthanolRed | cds-NP_013316.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:553358-554440:- | gene-YLR215C_FaliES1 | rna-NM_001182102.1_FaliES1 | cds-NP_013316.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000004.1:80263-81345:- | gene-YLR215C_JAY291 | rna-NM_001182102.1_JAY291 | cds-NP_013316.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:566007-567089:- | gene-YLR215C_MUCL30387 | rna-NM_001182102.1_MUCL30387 | cds-NP_013316.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:570128-571210:- | gene-YLR215C_MUCL30388 | rna-NM_001182102.1_MUCL30388 | cds-NP_013316.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:561394-562476:- | gene-YLR215C_MUCL39482 | rna-NM_001182102.1_MUCL39482 | cds-NP_013316.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:561894-562976:- | gene-YLR215C_MUCL42920 | rna-NM_001182102.1_MUCL42920 | cds-NP_013316.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:570750-571832:- | gene-YLR215C_NCIM3186 | rna-NM_001182102.1_NCIM3186 | cds-NP_013316.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:553813-554895:- | gene-YLR215C_NCYC1407 | rna-NM_001182102.1_NCYC1407 | cds-NP_013316.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:558066-559148:- | gene-YLR215C_PE2H3 | rna-NM_001182102.1_PE2H3 | cds-NP_013316.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:557810-558892:- | gene-YLR215C_PE2H4 | rna-NM_001182102.1_PE2H4 | cds-NP_013316.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:570776-571858:- | gene-YLR215C_S288C | rna-NM_001182102.1_S288C | cds-NP_013316.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000042.1:80314-81396:- | gene-YLR215C_SA1 | rna-NM_001182102.1_SA1 | cds-NP_013316.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:555851-556933:- | gene-YLR215C_ThermosaccDry | rna-NM_001182102.1_ThermosaccDry | cds-NP_013316.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:567200-568282:- | gene-YLR215C_VR1 | rna-NM_001182102.1_VR1 | cds-NP_013316.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000024.1:80139-81221:- | gene-YLR215C_ZTW1 | rna-NM_001182102.1_ZTW1 | cds-NP_013316.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:541999-543081:- | gene-YLR215C_Sparadoxus | rna-NM_001182102.1_Sparadoxus | cds-NP_013316.1_Sparadoxus | 90.4 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |