Gene name: CCZ1
Reference locus (S288C): YBR131W
Gene biotype: protein_coding
Description: Vacuolar fusion protein CCZ1; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy
Top 10 interactors (score): MON1 (0.999); YPT7 (0.998); GDI1 (0.937); VAM6 (0.91); MRS6 (0.9); VAM7 (0.891); VPS21 (0.879); VAM3 (0.869); VPS9 (0.784); VPS41 (0.762); PEP12 (0.727); YPP1 (0.712); TOR1 (0.69); VTI1 (0.671); NYV1 (0.671); TRS85 (0.636); ATG21 (0.632); ATG15 (0.611); VPS16 (0.609); ATG18 (0.598)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:480077-482191:+ | gene-YBR131W_AKU4011 | rna-NM_001178479.3_AKU4011 | cds-NP_009689.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:470618-472732:+ | gene-YBR131W_BG1 | rna-NM_001178479.3_BG1 | cds-NP_009689.3_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:481856-483970:+ | gene-YBR131W_Bruggeman | rna-NM_001178479.3_Bruggeman | cds-NP_009689.3_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:485024-487559:+ | gene-YBR131W_CAT1 | rna-NM_001178479.3_CAT1 | cds-NP_009689.3_CAT1 | 60.3 | 83.3 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:471860-473974:+ | gene-YBR131W_CBS1585 | rna-NM_001178479.3_CBS1585 | cds-NP_009689.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:479939-482053:+ | gene-YBR131W_CBS436 | rna-NM_001178479.3_CBS436 | cds-NP_009689.3_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:569723-571837:+ | gene-YBR131W_CBS6412 | rna-NM_001178479.3_CBS6412 | cds-NP_009689.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:477488-479602:+ | gene-YBR131W_CBS6413 | rna-NM_001178479.3_CBS6413 | cds-NP_009689.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:490932-493046:+ | gene-YBR131W_CENPK1137D | rna-NM_001178479.3_CENPK1137D | cds-NP_009689.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:606097-608211:+ | gene-YBR131W_EthanolRed | rna-NM_001178479.3_EthanolRed | cds-NP_009689.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:496114-498228:+ | gene-YBR131W_FaliES1 | rna-NM_001178479.3_FaliES1 | cds-NP_009689.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000444.1:19532-21646:+ | gene-YBR131W_JAY291 | rna-NM_001178479.3_JAY291 | cds-NP_009689.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:484737-486851:+ | gene-YBR131W_MUCL30387 | rna-NM_001178479.3_MUCL30387 | cds-NP_009689.3_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:483367-485481:+ | gene-YBR131W_MUCL30388 | rna-NM_001178479.3_MUCL30388 | cds-NP_009689.3_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:470253-472367:+ | gene-YBR131W_MUCL39482 | rna-NM_001178479.3_MUCL39482 | cds-NP_009689.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:480173-482287:+ | gene-YBR131W_MUCL42920 | rna-NM_001178479.3_MUCL42920 | cds-NP_009689.3_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:496960-499074:+ | gene-YBR131W_NCIM3186 | rna-NM_001178479.3_NCIM3186 | cds-NP_009689.3_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:472781-474895:+ | gene-YBR131W_NCYC1407 | rna-NM_001178479.3_NCYC1407 | cds-NP_009689.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:485371-487485:+ | gene-YBR131W_PE2H3 | rna-NM_001178479.3_PE2H3 | cds-NP_009689.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:483047-485161:+ | gene-YBR131W_PE2H4 | rna-NM_001178479.3_PE2H4 | cds-NP_009689.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:497163-499277:+ | gene-YBR131W_S288C | rna-NM_001178479.3_S288C | cds-NP_009689.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:18297-20411:+ | gene-YBR131W_SA1 | rna-NM_001178479.3_SA1 | cds-NP_009689.3_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:495121-497235:+ | gene-YBR131W_ThermosaccDry | rna-NM_001178479.3_ThermosaccDry | cds-NP_009689.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:476618-478732:+ | gene-YBR131W_VR1 | rna-NM_001178479.3_VR1 | cds-NP_009689.3_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:470271-472385:+ | gene-YBR131W_ZTW1 | rna-NM_001178479.3_ZTW1 | cds-NP_009689.3_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:507499-509616:+ | gene-YBR131W_Sparadoxus | rna-NM_001178479.3_Sparadoxus | cds-NP_009689.3_Sparadoxus | 86.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |