Gene name: CCC2
Reference locus (S288C): YDR270W
Gene biotype: protein_coding
Description: Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant
Top 10 interactors (score): ATX1 (0.999); FET3 (0.985); FTR1 (0.96); CTR2 (0.954); CTR3 (0.954); SUR1 (0.939); COX17 (0.916); COX11 (0.897); CCS1 (0.89); SMF3 (0.877); SCO1 (0.877); SOD1 (0.859); VMA1 (0.85); VPS41 (0.85); GEF1 (0.84); FRE1 (0.838); FET5 (0.821); COT1 (0.811); ICS3 (0.811); FET4 (0.794)
Homologues (species, bitscore): ATP7B (Homo sapiens, 536.2); Atp7b (Mus musculus, 533.9); atp7a (Danio rerio, 513.8); atp7b (Xenopus tropicalis, 513.5); ATP7 (Drosophila melanogaster, 464.5); cua-1 (Caenorhabditis elegans, 529.3); RAN1 (Arabidopsis thaliana, 582.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:957969-960983:+ | gene-YDR270W_AKU4011 | rna-NM_001180578.1_AKU4011 | cds-NP_010556.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:171347-174361:- | gene-YDR270W_BG1 | rna-NM_001180578.1_BG1 | cds-NP_010556.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:984140-987154:+ | gene-YDR270W_Bruggeman | rna-NM_001180578.1_Bruggeman | cds-NP_010556.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:971984-974998:+ | gene-YDR270W_CAT1 | rna-NM_001180578.1_CAT1 | cds-NP_010556.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:952414-955428:+ | gene-YDR270W_CBS1585 | rna-NM_001180578.1_CBS1585 | cds-NP_010556.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:970446-973460:+ | gene-YDR270W_CBS436 | rna-NM_001180578.1_CBS436 | cds-NP_010556.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:949097-952111:+ | gene-YDR270W_CBS6412 | rna-NM_001180578.1_CBS6412 | cds-NP_010556.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:970333-973347:+ | gene-YDR270W_CBS6413 | rna-NM_001180578.1_CBS6413 | cds-NP_010556.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1004318-1007332:+ | gene-YDR270W_CENPK1137D | rna-NM_001180578.1_CENPK1137D | cds-NP_010556.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:956515-959529:+ | gene-YDR270W_EthanolRed | rna-NM_001180578.1_EthanolRed | cds-NP_010556.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:964717-967731:+ | gene-YDR270W_FaliES1 | rna-NM_001180578.1_FaliES1 | cds-NP_010556.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000176.1:12970-15984:+ | gene-YDR270W_JAY291 | rna-NM_001180578.1_JAY291 | cds-NP_010556.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:969776-972790:+ | gene-YDR270W_MUCL30387 | rna-NM_001180578.1_MUCL30387 | cds-NP_010556.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:957485-960499:+ | gene-YDR270W_MUCL30388 | rna-NM_001180578.1_MUCL30388 | cds-NP_010556.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:944220-947234:+ | gene-YDR270W_MUCL39482 | rna-NM_001180578.1_MUCL39482 | cds-NP_010556.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:884216-887230:+ | gene-YDR270W_MUCL42920 | rna-NM_001180578.1_MUCL42920 | cds-NP_010556.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1005598-1008612:+ | gene-YDR270W_NCIM3186 | rna-NM_001180578.1_NCIM3186 | cds-NP_010556.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:957510-960524:+ | gene-YDR270W_NCYC1407 | rna-NM_001180578.1_NCYC1407 | cds-NP_010556.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:968141-971155:+ | gene-YDR270W_PE2H3 | rna-NM_001180578.1_PE2H3 | cds-NP_010556.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:973415-976429:+ | gene-YDR270W_PE2H4 | rna-NM_001180578.1_PE2H4 | cds-NP_010556.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1005675-1008689:+ | gene-YDR270W_S288C | rna-NM_001180578.1_S288C | cds-NP_010556.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000102.1:13296-16310:+ | gene-YDR270W_SA1 | rna-NM_001180578.1_SA1 | cds-NP_010556.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:969002-972016:+ | gene-YDR270W_ThermosaccDry | rna-NM_001180578.1_ThermosaccDry | cds-NP_010556.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:984595-987609:+ | gene-YDR270W_VR1 | rna-NM_001180578.1_VR1 | cds-NP_010556.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:13129-16144:+ | gene-YDR270W_ZTW1 | rna-NM_001180578.1_ZTW1 | cds-NP_010556.1_ZTW1 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:965422-968436:+ | gene-YDR270W_Sparadoxus | rna-NM_001180578.1_Sparadoxus | cds-NP_010556.1_Sparadoxus | 88.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |