Gene name: CAK1
Reference locus (S288C): YFL029C
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase CAK1; Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
Top 10 interactors (score): CKS1 (0.993); SWE1 (0.991); KIN28 (0.989); CDC28 (0.987); POL30 (0.967); SSN3 (0.967); CCL1 (0.964); YGK3 (0.961); CLB2 (0.954); MIH1 (0.947); CDC6 (0.925); CTK2 (0.925); CLB1 (0.921); TFB3 (0.906); CTK1 (0.859); CDC37 (0.857); SGV1 (0.842); IPL1 (0.839); CTR9 (0.836); MCM5 (0.828)
Homologues (species, bitscore): CDK20 (Homo sapiens, 79.7); Cdk20 (Mus musculus, 80.1); cdk20 (Danio rerio, 78.2); cdk7 (Xenopus tropicalis, 73.9); Cdk2 (Drosophila melanogaster, 80.5); cdk-5 (Caenorhabditis elegans, 73.2); CDKB1;1 (Arabidopsis thaliana, 82.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:74397-75503:- | gene-YFL029C_AKU4011 | rna-NM_001179937.1_AKU4011 | cds-NP_116624.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000089.1:4733-5839:- | gene-YFL029C_BG1 | rna-NM_001179937.1_BG1 | cds-NP_116624.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:73275-74381:- | gene-YFL029C_Bruggeman | rna-NM_001179937.1_Bruggeman | cds-NP_116624.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:78422-79528:- | gene-YFL029C_CAT1 | rna-NM_001179937.1_CAT1 | cds-NP_116624.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:75205-76311:- | gene-YFL029C_CBS1585 | rna-NM_001179937.1_CBS1585 | cds-NP_116624.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:48721-49827:- | gene-YFL029C_CBS436 | rna-NM_001179937.1_CBS436 | cds-NP_116624.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:74939-76045:- | gene-YFL029C_CBS6412 | rna-NM_001179937.1_CBS6412 | cds-NP_116624.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:77474-78580:- | gene-YFL029C_CBS6413 | rna-NM_001179937.1_CBS6413 | cds-NP_116624.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:74381-75487:- | gene-YFL029C_CENPK1137D | rna-NM_001179937.1_CENPK1137D | cds-NP_116624.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:73362-74468:- | gene-YFL029C_EthanolRed | rna-NM_001179937.1_EthanolRed | cds-NP_116624.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:75001-76107:- | gene-YFL029C_FaliES1 | rna-NM_001179937.1_FaliES1 | cds-NP_116624.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000448.1:83402-84508:- | gene-YFL029C_JAY291 | rna-NM_001179937.1_JAY291 | cds-NP_116624.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:75370-76476:- | gene-YFL029C_MUCL30387 | rna-NM_001179937.1_MUCL30387 | cds-NP_116624.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:73307-74413:- | gene-YFL029C_MUCL30388 | rna-NM_001179937.1_MUCL30388 | cds-NP_116624.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:73590-74696:- | gene-YFL029C_MUCL39482 | rna-NM_001179937.1_MUCL39482 | cds-NP_116624.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:71710-72816:- | gene-YFL029C_MUCL42920 | rna-NM_001179937.1_MUCL42920 | cds-NP_116624.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:78054-79160:- | gene-YFL029C_NCIM3186 | rna-NM_001179937.1_NCIM3186 | cds-NP_116624.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:74679-75785:- | gene-YFL029C_NCYC1407 | rna-NM_001179937.1_NCYC1407 | cds-NP_116624.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:94592-95698:- | gene-YFL029C_PE2H3 | rna-NM_001179937.1_PE2H3 | cds-NP_116624.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:94143-95249:- | gene-YFL029C_PE2H4 | rna-NM_001179937.1_PE2H4 | cds-NP_116624.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:78055-79161:- | gene-YFL029C_S288C | rna-NM_001179937.1_S288C | cds-NP_116624.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000117.1:2121-3227:- | gene-YFL029C_SA1 | rna-NM_001179937.1_SA1 | cds-NP_116624.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:74184-75290:- | gene-YFL029C_ThermosaccDry | rna-NM_001179937.1_ThermosaccDry | cds-NP_116624.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:82730-83836:- | gene-YFL029C_VR1 | rna-NM_001179937.1_VR1 | cds-NP_116624.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:4666-5772:- | gene-YFL029C_ZTW1 | rna-NM_001179937.1_ZTW1 | cds-NP_116624.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:98450-99553:- | gene-YFL029C_Sparadoxus | rna-NM_001179937.1_Sparadoxus | cds-NP_116624.1_Sparadoxus | 86.8 | 99.5 | Verified | 1 | 1 | 1 | False | True | False | False | False |