Gene name: BUB1
Reference locus (S288C): YGR188C
Gene biotype: protein_coding
Description: Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication
Top 10 interactors (score): MPS1 (0.999); SPC105 (0.999); CDC5 (0.999); MAD2 (0.999); BUB3 (0.999); CDC20 (0.999); NDC80 (0.998); MAD1 (0.997); CDC27 (0.997); ESP1 (0.996); CDC23 (0.99); CDH1 (0.989); CIN8 (0.989); CDC16 (0.987); DOC1 (0.987); APC1 (0.981); BUB2 (0.981); CDC28 (0.98); APC4 (0.979); NUF2 (0.973)
Homologues (species, bitscore): BUB1 (Homo sapiens, 174.5); Bub1 (Mus musculus, 162.9); bub1 (Danio rerio, 167.9); bub1 (Xenopus tropicalis, 183.7); Bub1 (Drosophila melanogaster, 155.6); bub-1 (Caenorhabditis elegans, 120.9); AT2G20635 (Arabidopsis thaliana, 188.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:839798-842860:- | gene-YGR188C_AKU4011 | rna-NM_001181317.3_AKU4011 | cds-NP_011704.3_AKU4011 | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:117905-120970:- | gene-YGR188C_BG1 | rna-NM_001181317.3_BG1 | cds-NP_011704.3_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:845726-848791:- | gene-YGR188C_Bruggeman | rna-NM_001181317.3_Bruggeman | cds-NP_011704.3_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:841827-844892:- | gene-YGR188C_CAT1 | rna-NM_001181317.3_CAT1 | cds-NP_011704.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:840514-843576:- | gene-YGR188C_CBS1585 | rna-NM_001181317.3_CBS1585 | cds-NP_011704.3_CBS1585 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:844404-847469:- | gene-YGR188C_CBS436 | rna-NM_001181317.3_CBS436 | cds-NP_011704.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:831885-834947:- | gene-YGR188C_CBS6412 | rna-NM_001181317.3_CBS6412 | cds-NP_011704.3_CBS6412 | 99.4 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:837380-840442:- | gene-YGR188C_CBS6413 | rna-NM_001181317.3_CBS6413 | cds-NP_011704.3_CBS6413 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:871770-874835:- | gene-YGR188C_CENPK1137D | rna-NM_001181317.3_CENPK1137D | cds-NP_011704.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:826387-829452:- | gene-YGR188C_EthanolRed | rna-NM_001181317.3_EthanolRed | cds-NP_011704.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:830778-833843:- | gene-YGR188C_FaliES1 | rna-NM_001181317.3_FaliES1 | cds-NP_011704.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000364.1:942-4007:+ | gene-YGR188C_JAY291 | rna-NM_001181317.3_JAY291 | cds-NP_011704.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:843216-846281:- | gene-YGR188C_MUCL30387 | rna-NM_001181317.3_MUCL30387 | cds-NP_011704.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:842927-845992:- | gene-YGR188C_MUCL30388 | rna-NM_001181317.3_MUCL30388 | cds-NP_011704.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:836087-839149:- | gene-YGR188C_MUCL39482 | rna-NM_001181317.3_MUCL39482 | cds-NP_011704.3_MUCL39482 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:852705-855770:- | gene-YGR188C_MUCL42920 | rna-NM_001181317.3_MUCL42920 | cds-NP_011704.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:872044-875109:- | gene-YGR188C_NCIM3186 | rna-NM_001181317.3_NCIM3186 | cds-NP_011704.3_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:831197-834259:- | gene-YGR188C_NCYC1407 | rna-NM_001181317.3_NCYC1407 | cds-NP_011704.3_NCYC1407 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:850389-853454:- | gene-YGR188C_PE2H3 | rna-NM_001181317.3_PE2H3 | cds-NP_011704.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:855499-858564:- | gene-YGR188C_PE2H4 | rna-NM_001181317.3_PE2H4 | cds-NP_011704.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:872044-875109:- | gene-YGR188C_S288C | rna-NM_001181317.3_S288C | cds-NP_011704.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000035.1:95760-98825:- | gene-YGR188C_SA1 | rna-NM_001181317.3_SA1 | cds-NP_011704.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:851289-854354:- | gene-YGR188C_ThermosaccDry | rna-NM_001181317.3_ThermosaccDry | cds-NP_011704.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:955537-958602:- | gene-YGR188C_VR1 | rna-NM_001181317.3_VR1 | cds-NP_011704.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:152725-155790:- | gene-YGR188C_ZTW1 | rna-NM_001181317.3_ZTW1 | cds-NP_011704.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:842892-845969:- | gene-YGR188C_Sparadoxus | rna-NM_001181317.3_Sparadoxus | cds-NP_011704.3_Sparadoxus | 88.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |