Gene name: BRE1
Reference locus (S288C): YDL074C
Gene biotype: protein_coding
Description: E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing
Top 10 interactors (score): RAD6 (0.999); LGE1 (0.998); SET2 (0.993); HTB1 (0.991); SET1 (0.988); DOT1 (0.987); HTB2 (0.985); RAD9 (0.981); SWD3 (0.981); RTF1 (0.977); UBP8 (0.968); LEO1 (0.964); SWD2 (0.961); CDC73 (0.958); HTZ1 (0.954); CTR9 (0.946); SWR1 (0.945); SWD1 (0.941); HHT1 (0.941); HHT2 (0.925)
Homologues (species, bitscore): RNF40 (Homo sapiens, 81.6); Rnf40 (Mus musculus, 82.4); rnf40 (Danio rerio, 78.2); rnf40 (Xenopus tropicalis, 71.2); Bre1 (Drosophila melanogaster, 81.6); rfp-1 (Caenorhabditis elegans, 58.5); HUB1 (Arabidopsis thaliana, 64.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:308635-310737:- | gene-YDL074C_AKU4011 | rna-NM_001180133.1_AKU4011 | cds-NP_010209.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:239197-241299:+ | gene-YDL074C_BG1 | rna-NM_001180133.1_BG1 | cds-NP_010209.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:326441-328543:- | gene-YDL074C_Bruggeman | rna-NM_001180133.1_Bruggeman | cds-NP_010209.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:322803-324905:- | gene-YDL074C_CAT1 | rna-NM_001180133.1_CAT1 | cds-NP_010209.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:306907-309009:- | gene-YDL074C_CBS1585 | rna-NM_001180133.1_CBS1585 | cds-NP_010209.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:323599-325701:- | gene-YDL074C_CBS436 | rna-NM_001180133.1_CBS436 | cds-NP_010209.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:305336-307438:- | gene-YDL074C_CBS6412 | rna-NM_001180133.1_CBS6412 | cds-NP_010209.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:324960-327062:- | gene-YDL074C_CBS6413 | rna-NM_001180133.1_CBS6413 | cds-NP_010209.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:322870-324972:- | gene-YDL074C_CENPK1137D | rna-NM_001180133.1_CENPK1137D | cds-NP_010209.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:319667-321769:- | gene-YDL074C_EthanolRed | rna-NM_001180133.1_EthanolRed | cds-NP_010209.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:325639-327741:- | gene-YDL074C_FaliES1 | rna-NM_001180133.1_FaliES1 | cds-NP_010209.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:95707-97809:- | gene-YDL074C_JAY291 | rna-NM_001180133.1_JAY291 | cds-NP_010209.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:323831-325933:- | gene-YDL074C_MUCL30387 | rna-NM_001180133.1_MUCL30387 | cds-NP_010209.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:314957-317059:- | gene-YDL074C_MUCL30388 | rna-NM_001180133.1_MUCL30388 | cds-NP_010209.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:308012-310114:- | gene-YDL074C_MUCL39482 | rna-NM_001180133.1_MUCL39482 | cds-NP_010209.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:230017-232119:- | gene-YDL074C_MUCL42920 | rna-NM_001180133.1_MUCL42920 | cds-NP_010209.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:323970-326072:- | gene-YDL074C_NCIM3186 | rna-NM_001180133.1_NCIM3186 | cds-NP_010209.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:308026-310128:- | gene-YDL074C_NCYC1407 | rna-NM_001180133.1_NCYC1407 | cds-NP_010209.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:314825-316927:- | gene-YDL074C_PE2H3 | rna-NM_001180133.1_PE2H3 | cds-NP_010209.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:314826-316928:- | gene-YDL074C_PE2H4 | rna-NM_001180133.1_PE2H4 | cds-NP_010209.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:324047-326149:- | gene-YDL074C_S288C | rna-NM_001180133.1_S288C | cds-NP_010209.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:108782-110884:+ | gene-YDL074C_SA1 | rna-NM_001180133.1_SA1 | cds-NP_010209.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:325150-327252:- | gene-YDL074C_ThermosaccDry | rna-NM_001180133.1_ThermosaccDry | cds-NP_010209.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:327222-329324:- | gene-YDL074C_VR1 | rna-NM_001180133.1_VR1 | cds-NP_010209.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:323070-325172:- | gene-YDL074C_ZTW1 | rna-NM_001180133.1_ZTW1 | cds-NP_010209.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:325216-327318:- | gene-YDL074C_Sparadoxus | rna-NM_001180133.1_Sparadoxus | cds-NP_010209.1_Sparadoxus | 89.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |