Gene name: BPL1
Reference locus (S288C): YDL141W
Gene biotype: protein_coding
Description: Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant
Top 10 interactors (score): ACC1 (0.995); BIO2 (0.984); HFA1 (0.967); DUR1,2 (0.945); BIO4 (0.886); ARC1 (0.809); PYC2 (0.797); PYC1 (0.787); SAM2 (0.752); TRP3 (0.735); COQ2 (0.692); REX2 (0.689); RPB10 (0.682); NIT3 (0.663); PFF1 (0.653); RPB9 (0.647); FAA2 (0.621); APC11 (0.618); PAN6 (0.616); LIP2 (0.614)
Homologues (species, bitscore): HLCS (Homo sapiens, 167.2); Hlcs (Mus musculus, 172.2); hlcs (Xenopus tropicalis, 159.8); Hcs (Drosophila melanogaster, 115.5); bpl-1 (Caenorhabditis elegans, 116.3); HCS1 (Arabidopsis thaliana, 104.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:187456-189528:+ | gene-YDL141W_AKU4011 | rna-NM_001180201.1_AKU4011 | cds-NP_010140.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:360250-362322:- | gene-YDL141W_BG1 | rna-NM_001180201.1_BG1 | cds-NP_010140.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:203499-205571:+ | gene-YDL141W_Bruggeman | rna-NM_001180201.1_Bruggeman | cds-NP_010140.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:201821-203893:+ | gene-YDL141W_CAT1 | rna-NM_001180201.1_CAT1 | cds-NP_010140.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:185487-187559:+ | gene-YDL141W_CBS1585 | rna-NM_001180201.1_CBS1585 | cds-NP_010140.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:202426-204498:+ | gene-YDL141W_CBS436 | rna-NM_001180201.1_CBS436 | cds-NP_010140.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:184740-186812:+ | gene-YDL141W_CBS6412 | rna-NM_001180201.1_CBS6412 | cds-NP_010140.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:203925-205997:+ | gene-YDL141W_CBS6413 | rna-NM_001180201.1_CBS6413 | cds-NP_010140.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:201691-203763:+ | gene-YDL141W_CENPK1137D | rna-NM_001180201.1_CENPK1137D | cds-NP_010140.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:198695-200767:+ | gene-YDL141W_EthanolRed | rna-NM_001180201.1_EthanolRed | cds-NP_010140.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:204227-206299:+ | gene-YDL141W_FaliES1 | rna-NM_001180201.1_FaliES1 | cds-NP_010140.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000032.1:13250-15322:- | gene-YDL141W_JAY291 | rna-NM_001180201.1_JAY291 | cds-NP_010140.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:202613-204685:+ | gene-YDL141W_MUCL30387 | rna-NM_001180201.1_MUCL30387 | cds-NP_010140.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:193473-195545:+ | gene-YDL141W_MUCL30388 | rna-NM_001180201.1_MUCL30388 | cds-NP_010140.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:186642-188714:+ | gene-YDL141W_MUCL39482 | rna-NM_001180201.1_MUCL39482 | cds-NP_010140.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | MBVV01000205.1:13206-15278:- | gene-YDL141W_MUCL42920 | rna-NM_001180201.1_MUCL42920 | cds-NP_010140.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:202962-205034:+ | gene-YDL141W_NCIM3186 | rna-NM_001180201.1_NCIM3186 | cds-NP_010140.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:186576-188648:+ | gene-YDL141W_NCYC1407 | rna-NM_001180201.1_NCYC1407 | cds-NP_010140.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:193819-195891:+ | gene-YDL141W_PE2H3 | rna-NM_001180201.1_PE2H3 | cds-NP_010140.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:193823-195895:+ | gene-YDL141W_PE2H4 | rna-NM_001180201.1_PE2H4 | cds-NP_010140.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:203039-205111:+ | gene-YDL141W_S288C | rna-NM_001180201.1_S288C | cds-NP_010140.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000043.1:68597-70669:+ | gene-YDL141W_SA1 | rna-NM_001180201.1_SA1 | cds-NP_010140.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:203988-206060:+ | gene-YDL141W_ThermosaccDry | rna-NM_001180201.1_ThermosaccDry | cds-NP_010140.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:204582-206654:+ | gene-YDL141W_VR1 | rna-NM_001180201.1_VR1 | cds-NP_010140.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:202114-204186:+ | gene-YDL141W_ZTW1 | rna-NM_001180201.1_ZTW1 | cds-NP_010140.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:204241-206313:+ | gene-YDL141W_Sparadoxus | rna-NM_001180201.1_Sparadoxus | cds-NP_010140.1_Sparadoxus | 90.8 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |