Gene name: BLM10
Reference locus (S288C): YFL007W
Gene biotype: protein_coding
Description: Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
Top 10 interactors (score): PUP1 (0.999); PRE6 (0.999); PUP2 (0.999); PRE9 (0.999); PRE3 (0.999); PRE4 (0.999); RPT4 (0.999); PRE1 (0.999); PRE5 (0.999); PRE10 (0.999); PRE8 (0.999); PRE7 (0.999); PUP3 (0.999); PRE2 (0.997); RPN5 (0.997); SCL1 (0.997); RPN11 (0.996); RPN13 (0.995); RPN2 (0.994); RPN10 (0.992)
Homologues (species, bitscore): PSME4 (Homo sapiens, 57.8); Psme4 (Mus musculus, 55.5); ENSDARP00000107560 (Danio rerio, 64.3); psme4 (Xenopus tropicalis, 50.8); C14C10.5 (Caenorhabditis elegans, 63.2); PA200 (Arabidopsis thaliana, 82.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:119888-126319:+ | gene-YFL007W_AKU4011 | rna-NM_001179959.1_AKU4011 | cds-NP_116648.2_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000079.1:5612-12043:+ | gene-YFL007W_BG1 | rna-NM_001179959.1_BG1 | cds-NP_116648.2_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:119455-125886:+ | gene-YFL007W_Bruggeman | rna-NM_001179959.1_Bruggeman | cds-NP_116648.2_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:125441-131872:+ | gene-YFL007W_CAT1 | rna-NM_001179959.1_CAT1 | cds-NP_116648.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:120713-127144:+ | gene-YFL007W_CBS1585 | rna-NM_001179959.1_CBS1585 | cds-NP_116648.2_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:95383-101814:+ | gene-YFL007W_CBS436 | rna-NM_001179959.1_CBS436 | cds-NP_116648.2_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:120454-126885:+ | gene-YFL007W_CBS6412 | rna-NM_001179959.1_CBS6412 | cds-NP_116648.2_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:122964-129395:+ | gene-YFL007W_CBS6413 | rna-NM_001179959.1_CBS6413 | cds-NP_116648.2_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:119763-126194:+ | gene-YFL007W_CENPK1137D | rna-NM_001179959.1_CENPK1137D | cds-NP_116648.2_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:118874-125305:+ | gene-YFL007W_EthanolRed | rna-NM_001179959.1_EthanolRed | cds-NP_116648.2_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:120521-126952:+ | gene-YFL007W_FaliES1 | rna-NM_001179959.1_FaliES1 | cds-NP_116648.2_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000450.1:5527-11958:+ | gene-YFL007W_JAY291 | rna-NM_001179959.1_JAY291 | cds-NP_116648.2_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:121085-127516:+ | gene-YFL007W_MUCL30387 | rna-NM_001179959.1_MUCL30387 | cds-NP_116648.2_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:119057-125488:+ | gene-YFL007W_MUCL30388 | rna-NM_001179959.1_MUCL30388 | cds-NP_116648.2_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:119157-125588:+ | gene-YFL007W_MUCL39482 | rna-NM_001179959.1_MUCL39482 | cds-NP_116648.2_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:118421-124852:+ | gene-YFL007W_MUCL42920 | rna-NM_001179959.1_MUCL42920 | cds-NP_116648.2_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:123478-129909:+ | gene-YFL007W_NCIM3186 | rna-NM_001179959.1_NCIM3186 | cds-NP_116648.2_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:120172-126603:+ | gene-YFL007W_NCYC1407 | rna-NM_001179959.1_NCYC1407 | cds-NP_116648.2_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:140061-146492:+ | gene-YFL007W_PE2H3 | rna-NM_001179959.1_PE2H3 | cds-NP_116648.2_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:139609-146040:+ | gene-YFL007W_PE2H4 | rna-NM_001179959.1_PE2H4 | cds-NP_116648.2_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:123479-129910:+ | gene-YFL007W_S288C | rna-NM_001179959.1_S288C | cds-NP_116648.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:187528-193959:- | gene-YFL007W_SA1 | rna-NM_001179959.1_SA1 | cds-NP_116648.2_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:119681-126112:+ | gene-YFL007W_ThermosaccDry | rna-NM_001179959.1_ThermosaccDry | cds-NP_116648.2_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:129571-136002:+ | gene-YFL007W_VR1 | rna-NM_001179959.1_VR1 | cds-NP_116648.2_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:50130-56561:+ | gene-YFL007W_ZTW1 | rna-NM_001179959.1_ZTW1 | cds-NP_116648.2_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:144197-150628:+ | gene-YFL007W_Sparadoxus | rna-NM_001179959.1_Sparadoxus | cds-NP_116648.2_Sparadoxus | 90.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |