Gene name: BIO4
Reference locus (S288C): YNR057C
Gene biotype: protein_coding
Description: Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels
Top 10 interactors (score): BIO3 (0.999); BIO2 (0.999); BIO5 (0.995); VHT1 (0.931); YJR154W (0.9); BPL1 (0.886); AAD10 (0.883); YPL245W (0.766); VHR1 (0.713); UBS1 (0.672); TRP3 (0.665); BDS1 (0.651); HIS4 (0.641); CEM1 (0.603); SER3 (0.601); FOL2 (0.6); SPE1 (0.582); YFR045W (0.574); YJL218W (0.573); YMR090W (0.573)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:218082-218795:+ | gene-YNR057C_AKU4011 | rna-NM_001183234.1_AKU4011 | cds-NP_014455.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:624927-625640:- | gene-YNR057C_BG1 | rna-NM_001183234.1_BG1 | cds-NP_014455.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:735087-735800:- | gene-YNR057C_Bruggeman | rna-NM_001183234.1_Bruggeman | cds-NP_014455.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:769530-770243:- | gene-YNR057C_CAT1 | rna-NM_001183234.1_CAT1 | cds-NP_014455.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:722243-722956:- | gene-YNR057C_CBS1585 | rna-NM_001183234.1_CBS1585 | cds-NP_014455.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:785102-785815:- | gene-YNR057C_CBS436 | rna-NM_001183234.1_CBS436 | cds-NP_014455.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:711225-711938:- | gene-YNR057C_CBS6412 | rna-NM_001183234.1_CBS6412 | cds-NP_014455.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:712906-713619:- | gene-YNR057C_CBS6413 | rna-NM_001183234.1_CBS6413 | cds-NP_014455.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:726992-727705:- | gene-YNR057C_CENPK1137D | rna-NM_001183234.1_CENPK1137D | cds-NP_014455.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:717884-718597:- | gene-YNR057C_EthanolRed | rna-NM_001183234.1_EthanolRed | cds-NP_014455.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:709076-709789:- | gene-YNR057C_FaliES1 | rna-NM_001183234.1_FaliES1 | cds-NP_014455.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000005.1:17947-18660:+ | gene-YNR057C_JAY291 | rna-NM_001183234.1_JAY291 | cds-NP_014455.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:733046-733759:- | gene-YNR057C_MUCL30387 | rna-NM_001183234.1_MUCL30387 | cds-NP_014455.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:774654-775367:- | gene-YNR057C_MUCL30388 | rna-NM_001183234.1_MUCL30388 | cds-NP_014455.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:713709-714422:- | gene-YNR057C_MUCL39482 | rna-NM_001183234.1_MUCL39482 | cds-NP_014455.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:720102-720815:- | gene-YNR057C_MUCL42920 | rna-NM_001183234.1_MUCL42920 | cds-NP_014455.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:733325-734038:- | gene-YNR057C_NCIM3186 | rna-NM_001183234.1_NCIM3186 | cds-NP_014455.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:716225-716938:- | gene-YNR057C_NCYC1407 | rna-NM_001183234.1_NCYC1407 | cds-NP_014455.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:717776-718489:- | gene-YNR057C_PE2H3 | rna-NM_001183234.1_PE2H3 | cds-NP_014455.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:719178-719891:- | gene-YNR057C_PE2H4 | rna-NM_001183234.1_PE2H4 | cds-NP_014455.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:733356-734069:- | gene-YNR057C_S288C | rna-NM_001183234.1_S288C | cds-NP_014455.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000087.1:35778-36491:+ | gene-YNR057C_SA1 | rna-NM_001183234.1_SA1 | cds-NP_014455.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:709419-710132:- | gene-YNR057C_ThermosaccDry | rna-NM_001183234.1_ThermosaccDry | cds-NP_014455.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:752664-753377:- | gene-YNR057C_VR1 | rna-NM_001183234.1_VR1 | cds-NP_014455.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:619185-619898:- | gene-YNR057C_ZTW1 | rna-NM_001183234.1_ZTW1 | cds-NP_014455.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:723430-724146:- | gene-YNR057C_Sparadoxus | rna-NM_001183234.1_Sparadoxus | cds-NP_014455.1_Sparadoxus | 92.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |