Gene name: BCS1
Reference locus (S288C): YDR375C
Gene biotype: protein_coding
Description: Mitochondrial chaperone BCS1; Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases
Top 10 interactors (score): CYT1 (0.99); CBP3 (0.969); ATP1 (0.967); QCR6 (0.965); QCR2 (0.964); QCR9 (0.952); TOM22 (0.95); TOM40 (0.948); QCR8 (0.947); ATP2 (0.933); CYB2 (0.928); TOM7 (0.922); QCR7 (0.921); TOM20 (0.919); TIM22 (0.916); AAC1 (0.915); HSP60 (0.914); TOM70 (0.913); ACO1 (0.909); RIP1 (0.908)
Homologues (species, bitscore): BCS1L (Homo sapiens, 439.9); Bcs1l (Mus musculus, 433.0); bcs1l (Danio rerio, 431.0); bcs1l (Xenopus tropicalis, 435.6); CG4908 (Drosophila melanogaster, 412.5); bcs-1 (Caenorhabditis elegans, 348.6); AT3G50940 (Arabidopsis thaliana, 132.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:560561-561931:- | gene-YDR375C_AKU4011 | rna-NM_001180683.1_AKU4011 | cds-NP_010663.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:43858-45228:- | gene-YDR375C_BG1 | rna-NM_001180683.1_BG1 | cds-NP_010663.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1195943-1197313:- | gene-YDR375C_Bruggeman | rna-NM_001180683.1_Bruggeman | cds-NP_010663.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1174550-1175920:- | gene-YDR375C_CAT1 | rna-NM_001180683.1_CAT1 | cds-NP_010663.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1160053-1161423:- | gene-YDR375C_CBS1585 | rna-NM_001180683.1_CBS1585 | cds-NP_010663.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1178607-1179977:- | gene-YDR375C_CBS436 | rna-NM_001180683.1_CBS436 | cds-NP_010663.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1156290-1157660:- | gene-YDR375C_CBS6412 | rna-NM_001180683.1_CBS6412 | cds-NP_010663.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1178180-1179550:- | gene-YDR375C_CBS6413 | rna-NM_001180683.1_CBS6413 | cds-NP_010663.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1223818-1225188:- | gene-YDR375C_CENPK1137D | rna-NM_001180683.1_CENPK1137D | cds-NP_010663.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1169709-1171079:- | gene-YDR375C_EthanolRed | rna-NM_001180683.1_EthanolRed | cds-NP_010663.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1172996-1174366:- | gene-YDR375C_FaliES1 | rna-NM_001180683.1_FaliES1 | cds-NP_010663.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000057.1:16713-18083:+ | gene-YDR375C_JAY291 | rna-NM_001180683.1_JAY291 | cds-NP_010663.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1179261-1180631:- | gene-YDR375C_MUCL30387 | rna-NM_001180683.1_MUCL30387 | cds-NP_010663.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1161871-1163241:- | gene-YDR375C_MUCL30388 | rna-NM_001180683.1_MUCL30388 | cds-NP_010663.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1151604-1152974:- | gene-YDR375C_MUCL39482 | rna-NM_001180683.1_MUCL39482 | cds-NP_010663.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1093991-1095361:- | gene-YDR375C_MUCL42920 | rna-NM_001180683.1_MUCL42920 | cds-NP_010663.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1225089-1226459:- | gene-YDR375C_NCIM3186 | rna-NM_001180683.1_NCIM3186 | cds-NP_010663.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1165575-1166945:- | gene-YDR375C_NCYC1407 | rna-NM_001180683.1_NCYC1407 | cds-NP_010663.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1175657-1177027:- | gene-YDR375C_PE2H3 | rna-NM_001180683.1_PE2H3 | cds-NP_010663.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1181242-1182612:- | gene-YDR375C_PE2H4 | rna-NM_001180683.1_PE2H4 | cds-NP_010663.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1225166-1226536:- | gene-YDR375C_S288C | rna-NM_001180683.1_S288C | cds-NP_010663.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000072.1:43939-45309:- | gene-YDR375C_SA1 | rna-NM_001180683.1_SA1 | cds-NP_010663.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1177277-1178647:- | gene-YDR375C_ThermosaccDry | rna-NM_001180683.1_ThermosaccDry | cds-NP_010663.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:604620-605990:- | gene-YDR375C_VR1 | rna-NM_001180683.1_VR1 | cds-NP_010663.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:220106-221476:- | gene-YDR375C_ZTW1 | rna-NM_001180683.1_ZTW1 | cds-NP_010663.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1171833-1173203:- | gene-YDR375C_Sparadoxus | rna-NM_001180683.1_Sparadoxus | cds-NP_010663.1_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |