Gene name: ATG5
Reference locus (S288C): YPL149W
Gene biotype: protein_coding
Description: Autophagy protein 5; Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner
Top 10 interactors (score): ATG16 (0.999); ATG12 (0.999); ATG8 (0.999); ATG3 (0.999); ATG18 (0.999); ATG7 (0.998); ATG9 (0.996); ATG4 (0.996); ATG1 (0.996); VPS34 (0.995); VPS30 (0.994); ATG2 (0.993); VPS15 (0.991); TUF1 (0.99); ATG21 (0.966); ATG11 (0.965); ATG10 (0.951); ATG29 (0.947); YPT7 (0.937); ATG13 (0.935)
Homologues (species, bitscore): ATG5 (Homo sapiens, 66.6); Atg5 (Mus musculus, 64.7); atg5 (Danio rerio, 64.3); atg5 (Xenopus tropicalis, 55.5); Atg5 (Drosophila melanogaster, 50.8); APG5 (Arabidopsis thaliana, 53.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:248965-249849:+ | gene-YPL149W_AKU4011 | rna-NM_001183963.1_AKU4011 | cds-NP_015176.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:454653-455537:+ | gene-YPL149W_BG1 | rna-NM_001183963.1_BG1 | cds-NP_015176.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:274958-275842:+ | gene-YPL149W_Bruggeman | rna-NM_001183963.1_Bruggeman | cds-NP_015176.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:271642-272526:+ | gene-YPL149W_CAT1 | rna-NM_001183963.1_CAT1 | cds-NP_015176.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:253028-253912:+ | gene-YPL149W_CBS1585 | rna-NM_001183963.1_CBS1585 | cds-NP_015176.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:267705-268589:+ | gene-YPL149W_CBS436 | rna-NM_001183963.1_CBS436 | cds-NP_015176.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:257706-258590:+ | gene-YPL149W_CBS6412 | rna-NM_001183963.1_CBS6412 | cds-NP_015176.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:249668-250552:+ | gene-YPL149W_CBS6413 | rna-NM_001183963.1_CBS6413 | cds-NP_015176.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:271212-272096:+ | gene-YPL149W_CENPK1137D | rna-NM_001183963.1_CENPK1137D | cds-NP_015176.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:247655-248539:+ | gene-YPL149W_EthanolRed | rna-NM_001183963.1_EthanolRed | cds-NP_015176.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:255247-256131:+ | gene-YPL149W_FaliES1 | rna-NM_001183963.1_FaliES1 | cds-NP_015176.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:109719-110603:- | gene-YPL149W_JAY291 | rna-NM_001183963.1_JAY291 | cds-NP_015176.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:266201-267085:+ | gene-YPL149W_MUCL30387 | rna-NM_001183963.1_MUCL30387 | cds-NP_015176.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:264218-265102:+ | gene-YPL149W_MUCL30388 | rna-NM_001183963.1_MUCL30388 | cds-NP_015176.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:246357-247241:+ | gene-YPL149W_MUCL39482 | rna-NM_001183963.1_MUCL39482 | cds-NP_015176.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:303598-304482:+ | gene-YPL149W_MUCL42920 | rna-NM_001183963.1_MUCL42920 | cds-NP_015176.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:271293-272177:+ | gene-YPL149W_NCIM3186 | rna-NM_001183963.1_NCIM3186 | cds-NP_015176.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:252820-253704:+ | gene-YPL149W_NCYC1407 | rna-NM_001183963.1_NCYC1407 | cds-NP_015176.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:260267-261151:+ | gene-YPL149W_PE2H3 | rna-NM_001183963.1_PE2H3 | cds-NP_015176.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:259898-260782:+ | gene-YPL149W_PE2H4 | rna-NM_001183963.1_PE2H4 | cds-NP_015176.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:271310-272194:+ | gene-YPL149W_S288C | rna-NM_001183963.1_S288C | cds-NP_015176.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:101493-102377:- | gene-YPL149W_SA1 | rna-NM_001183963.1_SA1 | cds-NP_015176.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:255045-255929:+ | gene-YPL149W_ThermosaccDry | rna-NM_001183963.1_ThermosaccDry | cds-NP_015176.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:270026-270910:+ | gene-YPL149W_VR1 | rna-NM_001183963.1_VR1 | cds-NP_015176.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:254373-255257:+ | gene-YPL149W_ZTW1 | rna-NM_001183963.1_ZTW1 | cds-NP_015176.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:256034-256918:+ | gene-YPL149W_Sparadoxus | rna-NM_001183963.1_Sparadoxus | cds-NP_015176.1_Sparadoxus | 85.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |