Gene name: ATG3
Reference locus (S288C): YNR007C
Gene biotype: protein_coding
Description: Autophagy-related protein 3; E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site
Top 10 interactors (score): ATG18 (0.999); ATG4 (0.999); ATG8 (0.999); ATG12 (0.999); ATG7 (0.999); VPS30 (0.999); ATG5 (0.999); VPS34 (0.998); VPS15 (0.996); ATG1 (0.995); ATG9 (0.994); ATG16 (0.992); ATG2 (0.991); ATG11 (0.966); ATG10 (0.962); ATG13 (0.96); ATG21 (0.913); ATG15 (0.909); YPT7 (0.905); ATG14 (0.904)
Homologues (species, bitscore): ATG3 (Homo sapiens, 171.0); Atg3 (Mus musculus, 167.9); apg3l (Danio rerio, 168.7); atg3 (Xenopus tropicalis, 161.8); Atg3 (Drosophila melanogaster, 169.5); atg-3 (Caenorhabditis elegans, 167.2); ATG3 (Arabidopsis thaliana, 137.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:622764-623696:- | gene-YNR007C_AKU4011 | rna-NM_001183184.3_AKU4011 | cds-NP_014404.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:530620-531552:- | gene-YNR007C_BG1 | rna-NM_001183184.3_BG1 | cds-NP_014404.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:640257-641189:- | gene-YNR007C_Bruggeman | rna-NM_001183184.3_Bruggeman | cds-NP_014404.3_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:674483-675415:- | gene-YNR007C_CAT1 | rna-NM_001183184.3_CAT1 | cds-NP_014404.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:628560-629492:- | gene-YNR007C_CBS1585 | rna-NM_001183184.3_CBS1585 | cds-NP_014404.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:690256-691188:- | gene-YNR007C_CBS436 | rna-NM_001183184.3_CBS436 | cds-NP_014404.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:618126-619058:- | gene-YNR007C_CBS6412 | rna-NM_001183184.3_CBS6412 | cds-NP_014404.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:619454-620386:- | gene-YNR007C_CBS6413 | rna-NM_001183184.3_CBS6413 | cds-NP_014404.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:632868-633800:- | gene-YNR007C_CENPK1137D | rna-NM_001183184.3_CENPK1137D | cds-NP_014404.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:624685-625617:- | gene-YNR007C_EthanolRed | rna-NM_001183184.3_EthanolRed | cds-NP_014404.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:615703-616635:- | gene-YNR007C_FaliES1 | rna-NM_001183184.3_FaliES1 | cds-NP_014404.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000037.1:86107-87039:+ | gene-YNR007C_JAY291 | rna-NM_001183184.3_JAY291 | cds-NP_014404.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:638009-638941:- | gene-YNR007C_MUCL30387 | rna-NM_001183184.3_MUCL30387 | cds-NP_014404.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:678843-679775:- | gene-YNR007C_MUCL30388 | rna-NM_001183184.3_MUCL30388 | cds-NP_014404.3_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:620068-621000:- | gene-YNR007C_MUCL39482 | rna-NM_001183184.3_MUCL39482 | cds-NP_014404.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:624252-625184:- | gene-YNR007C_MUCL42920 | rna-NM_001183184.3_MUCL42920 | cds-NP_014404.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:639151-640083:- | gene-YNR007C_NCIM3186 | rna-NM_001183184.3_NCIM3186 | cds-NP_014404.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:622570-623502:- | gene-YNR007C_NCYC1407 | rna-NM_001183184.3_NCYC1407 | cds-NP_014404.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:623661-624593:- | gene-YNR007C_PE2H3 | rna-NM_001183184.3_PE2H3 | cds-NP_014404.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:624979-625911:- | gene-YNR007C_PE2H4 | rna-NM_001183184.3_PE2H4 | cds-NP_014404.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:639182-640114:- | gene-YNR007C_S288C | rna-NM_001183184.3_S288C | cds-NP_014404.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000068.1:36886-37818:- | gene-YNR007C_SA1 | rna-NM_001183184.3_SA1 | cds-NP_014404.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:616043-616975:- | gene-YNR007C_ThermosaccDry | rna-NM_001183184.3_ThermosaccDry | cds-NP_014404.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:658006-658938:- | gene-YNR007C_VR1 | rna-NM_001183184.3_VR1 | cds-NP_014404.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:524949-525881:- | gene-YNR007C_ZTW1 | rna-NM_001183184.3_ZTW1 | cds-NP_014404.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:630143-631075:- | gene-YNR007C_Sparadoxus | rna-NM_001183184.3_Sparadoxus | cds-NP_014404.3_Sparadoxus | 91.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |