Gene name: ATG18
Reference locus (S288C): YFR021W
Gene biotype: protein_coding
Description: Autophagy-related protein 18; Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Top 10 interactors (score): ATG5 (0.999); ATG3 (0.999); ATG7 (0.999); VPS30 (0.999); VPS34 (0.999); ATG2 (0.999); ATG9 (0.999); ATG8 (0.999); ATG1 (0.998); VAC14 (0.998); VPS15 (0.998); FAB1 (0.997); FIG4 (0.996); ATG4 (0.996); ATG12 (0.996); VAC7 (0.994); ATG14 (0.983); ATG38 (0.973); ATG11 (0.971); ATG27 (0.96)
Homologues (species, bitscore): WIPI2 (Homo sapiens, 175.6); Wipi2 (Mus musculus, 189.9); wipi2 (Danio rerio, 190.3); wdr45b (Xenopus tropicalis, 152.5); Atg18b (Drosophila melanogaster, 164.9); atg-18 (Caenorhabditis elegans, 139.4); AtATG18a (Arabidopsis thaliana, 172.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:185049-186551:+ | gene-YFR021W_AKU4011 | rna-NM_001179986.1_AKU4011 | cds-NP_444297.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000071.1:74144-75646:- | gene-YFR021W_BG1 | rna-NM_001179986.1_BG1 | cds-NP_444297.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:187142-188644:+ | gene-YFR021W_Bruggeman | rna-NM_001179986.1_Bruggeman | cds-NP_444297.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:190415-191917:+ | gene-YFR021W_CAT1 | rna-NM_001179986.1_CAT1 | cds-NP_444297.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:186540-188042:+ | gene-YFR021W_CBS1585 | rna-NM_001179986.1_CBS1585 | cds-NP_444297.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:159739-161241:+ | gene-YFR021W_CBS436 | rna-NM_001179986.1_CBS436 | cds-NP_444297.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:185621-187123:+ | gene-YFR021W_CBS6412 | rna-NM_001179986.1_CBS6412 | cds-NP_444297.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:188275-189777:+ | gene-YFR021W_CBS6413 | rna-NM_001179986.1_CBS6413 | cds-NP_444297.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:190883-192385:+ | gene-YFR021W_CENPK1137D | rna-NM_001179986.1_CENPK1137D | cds-NP_444297.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:184156-185658:+ | gene-YFR021W_EthanolRed | rna-NM_001179986.1_EthanolRed | cds-NP_444297.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:185806-187308:+ | gene-YFR021W_FaliES1 | rna-NM_001179986.1_FaliES1 | cds-NP_444297.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000452.1:32532-34034:+ | gene-YFR021W_JAY291 | rna-NM_001179986.1_JAY291 | cds-NP_444297.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:188368-189870:+ | gene-YFR021W_MUCL30387 | rna-NM_001179986.1_MUCL30387 | cds-NP_444297.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:184625-186127:+ | gene-YFR021W_MUCL30388 | rna-NM_001179986.1_MUCL30388 | cds-NP_444297.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:184458-185960:+ | gene-YFR021W_MUCL39482 | rna-NM_001179986.1_MUCL39482 | cds-NP_444297.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:183770-185272:+ | gene-YFR021W_MUCL42920 | rna-NM_001179986.1_MUCL42920 | cds-NP_444297.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:194811-196313:+ | gene-YFR021W_NCIM3186 | rna-NM_001179986.1_NCIM3186 | cds-NP_444297.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:185340-186842:+ | gene-YFR021W_NCYC1407 | rna-NM_001179986.1_NCYC1407 | cds-NP_444297.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:227746-229248:+ | gene-YFR021W_PE2H3 | rna-NM_001179986.1_PE2H3 | cds-NP_444297.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:227294-228796:+ | gene-YFR021W_PE2H4 | rna-NM_001179986.1_PE2H4 | cds-NP_444297.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:194812-196314:+ | gene-YFR021W_S288C | rna-NM_001179986.1_S288C | cds-NP_444297.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:128092-129594:- | gene-YFR021W_SA1 | rna-NM_001179986.1_SA1 | cds-NP_444297.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:184963-186465:+ | gene-YFR021W_ThermosaccDry | rna-NM_001179986.1_ThermosaccDry | cds-NP_444297.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:200977-202479:+ | gene-YFR021W_VR1 | rna-NM_001179986.1_VR1 | cds-NP_444297.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:115437-116939:+ | gene-YFR021W_ZTW1 | rna-NM_001179986.1_ZTW1 | cds-NP_444297.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:208969-210471:+ | gene-YFR021W_Sparadoxus | rna-NM_001179986.1_Sparadoxus | cds-NP_444297.1_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |