Gene name: ATG12
Reference locus (S288C): YBR217W
Gene biotype: protein_coding
Description: Ubiquitin-like protein ATG12; Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation
Top 10 interactors (score): ATG16 (0.999); ATG8 (0.999); VPS30 (0.999); ATG7 (0.999); ATG5 (0.999); ATG3 (0.999); ATG10 (0.998); VPS34 (0.997); ATG9 (0.997); ATG4 (0.996); VPS15 (0.996); ATG18 (0.996); ATG1 (0.995); ATG2 (0.992); ATG11 (0.98); ATG21 (0.977); URM1 (0.954); ATG31 (0.939); ATG19 (0.922); ATG17 (0.918)
Homologues (species, bitscore): ATG12 (Homo sapiens, 58.9); Atg12 (Mus musculus, 58.5); atg12 (Danio rerio, 55.8); atg12 (Xenopus tropicalis, 63.2); Atg12 (Drosophila melanogaster, 55.1); APG12B (Arabidopsis thaliana, 68.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:642138-642698:+ | gene-YBR217W_AKU4011 | rna-NM_001178565.1_AKU4011 | cds-NP_009776.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:13059-13619:+ | gene-YBR217W_BG1 | rna-NM_001178565.1_BG1 | cds-NP_009776.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:643293-643853:+ | gene-YBR217W_Bruggeman | rna-NM_001178565.1_Bruggeman | cds-NP_009776.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:646497-647057:+ | gene-YBR217W_CAT1 | rna-NM_001178565.1_CAT1 | cds-NP_009776.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:633670-634230:+ | gene-YBR217W_CBS1585 | rna-NM_001178565.1_CBS1585 | cds-NP_009776.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:640095-640655:+ | gene-YBR217W_CBS436 | rna-NM_001178565.1_CBS436 | cds-NP_009776.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:728647-729207:+ | gene-YBR217W_CBS6412 | rna-NM_001178565.1_CBS6412 | cds-NP_009776.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:639708-640268:+ | gene-YBR217W_CBS6413 | rna-NM_001178565.1_CBS6413 | cds-NP_009776.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:651582-652142:+ | gene-YBR217W_CENPK1137D | rna-NM_001178565.1_CENPK1137D | cds-NP_009776.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:765383-765943:+ | gene-YBR217W_EthanolRed | rna-NM_001178565.1_EthanolRed | cds-NP_009776.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:658490-659050:+ | gene-YBR217W_FaliES1 | rna-NM_001178565.1_FaliES1 | cds-NP_009776.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000326.1:12863-13423:+ | gene-YBR217W_JAY291 | rna-NM_001178565.1_JAY291 | cds-NP_009776.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:645306-645866:+ | gene-YBR217W_MUCL30387 | rna-NM_001178565.1_MUCL30387 | cds-NP_009776.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:662386-662946:+ | gene-YBR217W_MUCL30388 | rna-NM_001178565.1_MUCL30388 | cds-NP_009776.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:632022-632582:+ | gene-YBR217W_MUCL39482 | rna-NM_001178565.1_MUCL39482 | cds-NP_009776.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:641504-642064:+ | gene-YBR217W_MUCL42920 | rna-NM_001178565.1_MUCL42920 | cds-NP_009776.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:657629-658189:+ | gene-YBR217W_NCIM3186 | rna-NM_001178565.1_NCIM3186 | cds-NP_009776.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:633884-634444:+ | gene-YBR217W_NCYC1407 | rna-NM_001178565.1_NCYC1407 | cds-NP_009776.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:657001-657561:+ | gene-YBR217W_PE2H3 | rna-NM_001178565.1_PE2H3 | cds-NP_009776.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:654677-655237:+ | gene-YBR217W_PE2H4 | rna-NM_001178565.1_PE2H4 | cds-NP_009776.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:657832-658392:+ | gene-YBR217W_S288C | rna-NM_001178565.1_S288C | cds-NP_009776.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:12956-13516:+ | gene-YBR217W_SA1 | rna-NM_001178565.1_SA1 | cds-NP_009776.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:657500-658060:+ | gene-YBR217W_ThermosaccDry | rna-NM_001178565.1_ThermosaccDry | cds-NP_009776.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:637672-638232:+ | gene-YBR217W_VR1 | rna-NM_001178565.1_VR1 | cds-NP_009776.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:630367-630927:+ | gene-YBR217W_ZTW1 | rna-NM_001178565.1_ZTW1 | cds-NP_009776.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:674348-674908:+ | gene-YBR217W_Sparadoxus | rna-NM_001178565.1_Sparadoxus | cds-NP_009776.1_Sparadoxus | 88.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |