Gene name: ASF1
Reference locus (S288C): YJL115W
Gene biotype: protein_coding
Description: Histone chaperone ASF1; Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B
Top 10 interactors (score): HIR3 (0.999); RAD53 (0.999); HIR1 (0.999); MCM2 (0.999); CAC2 (0.999); HHT1 (0.999); HHT2 (0.999); HIR2 (0.999); HHF1 (0.999); HAT1 (0.999); HIF1 (0.999); RTT109 (0.999); VPS75 (0.998); RTT106 (0.998); HAT2 (0.998); RLF2 (0.997); HTZ1 (0.994); HHF2 (0.994); HPC2 (0.993); POL30 (0.989)
Homologues (species, bitscore): ASF1A (Homo sapiens, 197.2); Asf1a (Mus musculus, 199.5); asf1ba (Danio rerio, 199.5); asf1b (Xenopus tropicalis, 201.4); asf1 (Drosophila melanogaster, 199.5); asfl-1 (Caenorhabditis elegans, 177.2); SGA2 (Arabidopsis thaliana, 192.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:184606-185445:+ | gene-YJL115W_AKU4011 | rna-NM_001181548.1_AKU4011 | cds-NP_012420.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:428314-429153:- | gene-YJL115W_BG1 | rna-NM_001181548.1_BG1 | cds-NP_012420.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:196653-197492:+ | gene-YJL115W_Bruggeman | rna-NM_001181548.1_Bruggeman | cds-NP_012420.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:200460-201299:+ | gene-YJL115W_CAT1 | rna-NM_001181548.1_CAT1 | cds-NP_012420.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:190239-191078:+ | gene-YJL115W_CBS1585 | rna-NM_001181548.1_CBS1585 | cds-NP_012420.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:214978-215817:+ | gene-YJL115W_CBS436 | rna-NM_001181548.1_CBS436 | cds-NP_012420.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:186260-187099:+ | gene-YJL115W_CBS6412 | rna-NM_001181548.1_CBS6412 | cds-NP_012420.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:187714-188553:+ | gene-YJL115W_CBS6413 | rna-NM_001181548.1_CBS6413 | cds-NP_012420.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:178753-179592:+ | gene-YJL115W_CENPK1137D | rna-NM_001181548.1_CENPK1137D | cds-NP_012420.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:188570-189409:+ | gene-YJL115W_EthanolRed | rna-NM_001181548.1_EthanolRed | cds-NP_012420.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:194226-195065:+ | gene-YJL115W_FaliES1 | rna-NM_001181548.1_FaliES1 | cds-NP_012420.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000099.1:75377-76216:+ | gene-YJL115W_JAY291 | rna-NM_001181548.1_JAY291 | cds-NP_012420.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:198921-199760:+ | gene-YJL115W_MUCL30387 | rna-NM_001181548.1_MUCL30387 | cds-NP_012420.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:194999-195838:+ | gene-YJL115W_MUCL30388 | rna-NM_001181548.1_MUCL30388 | cds-NP_012420.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:189185-190024:+ | gene-YJL115W_MUCL39482 | rna-NM_001181548.1_MUCL39482 | cds-NP_012420.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:194994-195833:+ | gene-YJL115W_MUCL42920 | rna-NM_001181548.1_MUCL42920 | cds-NP_012420.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:196266-197105:+ | gene-YJL115W_NCIM3186 | rna-NM_001181548.1_NCIM3186 | cds-NP_012420.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:187592-188431:+ | gene-YJL115W_NCYC1407 | rna-NM_001181548.1_NCYC1407 | cds-NP_012420.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:200359-201198:+ | gene-YJL115W_PE2H3 | rna-NM_001181548.1_PE2H3 | cds-NP_012420.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:200003-200842:+ | gene-YJL115W_PE2H4 | rna-NM_001181548.1_PE2H4 | cds-NP_012420.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:196287-197126:+ | gene-YJL115W_S288C | rna-NM_001181548.1_S288C | cds-NP_012420.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000085.1:2040-2879:- | gene-YJL115W_SA1 | rna-NM_001181548.1_SA1 | cds-NP_012420.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:187413-188252:+ | gene-YJL115W_ThermosaccDry | rna-NM_001181548.1_ThermosaccDry | cds-NP_012420.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:194475-195314:+ | gene-YJL115W_VR1 | rna-NM_001181548.1_VR1 | cds-NP_012420.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:174695-175534:+ | gene-YJL115W_ZTW1 | rna-NM_001181548.1_ZTW1 | cds-NP_012420.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:199926-200765:+ | gene-YJL115W_Sparadoxus | rna-NM_001181548.1_Sparadoxus | cds-NP_012420.1_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |