Gene name: ARV1
Reference locus (S288C): YLR242C
Gene biotype: protein_coding
Description: Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null
Top 10 interactors (score): LAS21 (0.909); ARE2 (0.909); NVJ2 (0.876); GWT1 (0.835); SAC1 (0.803); SCS2 (0.797); DRS1 (0.78); CWH41 (0.75); IRE1 (0.738); ARE1 (0.731); SEC63 (0.713); YBL062W (0.696); TMA23 (0.695); SEC66 (0.679); URA1 (0.67); CHO1 (0.653); OPI3 (0.652); ERG6 (0.641); CSG2 (0.624); GIM5 (0.613)
Homologues (species, bitscore): ARV1 (Homo sapiens, 61.6); Arv1 (Mus musculus, 63.2); arv1 (Danio rerio, 57.4); arv1 (Xenopus tropicalis, 60.5); CG32442 (Drosophila melanogaster, 56.2); R05H5.5 (Caenorhabditis elegans, 64.3); ARV2 (Arabidopsis thaliana, 62.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:577125-578093:- | gene-YLR242C_AKU4011 | rna-NM_001182129.1_AKU4011 | cds-NP_013343.1_AKU4011 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000170.1:153818-154783:+ | gene-YLR242C_BG1 | rna-NM_001182129.1_BG1 | cds-NP_013343.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:611363-612328:- | gene-YLR242C_Bruggeman | rna-NM_001182129.1_Bruggeman | cds-NP_013343.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:610487-611452:- | gene-YLR242C_CAT1 | rna-NM_001182129.1_CAT1 | cds-NP_013343.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:612620-613588:- | gene-YLR242C_CBS1585 | rna-NM_001182129.1_CBS1585 | cds-NP_013343.1_CBS1585 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:596829-597794:- | gene-YLR242C_CBS436 | rna-NM_001182129.1_CBS436 | cds-NP_013343.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:575595-576563:- | gene-YLR242C_CBS6412 | rna-NM_001182129.1_CBS6412 | cds-NP_013343.1_CBS6412 | 98.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:612915-613883:- | gene-YLR242C_CBS6413 | rna-NM_001182129.1_CBS6413 | cds-NP_013343.1_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:607529-608494:- | gene-YLR242C_CENPK1137D | rna-NM_001182129.1_CENPK1137D | cds-NP_013343.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:570662-571627:- | gene-YLR242C_EthanolRed | rna-NM_001182129.1_EthanolRed | cds-NP_013343.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:599587-600552:- | gene-YLR242C_FaliES1 | rna-NM_001182129.1_FaliES1 | cds-NP_013343.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000136.1:58338-59303:+ | gene-YLR242C_JAY291 | rna-NM_001182129.1_JAY291 | cds-NP_013343.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:612220-613185:- | gene-YLR242C_MUCL30387 | rna-NM_001182129.1_MUCL30387 | cds-NP_013343.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:616342-617307:- | gene-YLR242C_MUCL30388 | rna-NM_001182129.1_MUCL30388 | cds-NP_013343.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:613601-614569:- | gene-YLR242C_MUCL39482 | rna-NM_001182129.1_MUCL39482 | cds-NP_013343.1_MUCL39482 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:608363-609328:- | gene-YLR242C_MUCL42920 | rna-NM_001182129.1_MUCL42920 | cds-NP_013343.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:622892-623857:- | gene-YLR242C_NCIM3186 | rna-NM_001182129.1_NCIM3186 | cds-NP_013343.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:600590-601555:- | gene-YLR242C_NCYC1407 | rna-NM_001182129.1_NCYC1407 | cds-NP_013343.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:604307-605272:- | gene-YLR242C_PE2H3 | rna-NM_001182129.1_PE2H3 | cds-NP_013343.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:604051-605016:- | gene-YLR242C_PE2H4 | rna-NM_001182129.1_PE2H4 | cds-NP_013343.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:622918-623883:- | gene-YLR242C_S288C | rna-NM_001182129.1_S288C | cds-NP_013343.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:58589-59554:+ | gene-YLR242C_SA1 | rna-NM_001182129.1_SA1 | cds-NP_013343.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:602087-603052:- | gene-YLR242C_ThermosaccDry | rna-NM_001182129.1_ThermosaccDry | cds-NP_013343.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:613421-614386:- | gene-YLR242C_VR1 | rna-NM_001182129.1_VR1 | cds-NP_013343.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000024.1:126403-127368:- | gene-YLR242C_ZTW1 | rna-NM_001182129.1_ZTW1 | cds-NP_013343.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:587588-588553:- | gene-YLR242C_Sparadoxus | rna-NM_001182129.1_Sparadoxus | cds-NP_013343.1_Sparadoxus | 91.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |